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Reposted by Schlisio_lab

Karolinska Institutet @ki.se · 17/10/2025

Adrenal glia-support cells act as hidden #stemcells that regenerate tissue, but can also initiate adrenal #cancer. A new study in npj Precision Oncology by @schlisio-lab.bsky.social reveals a DLK1-NOTCH switch, deciding whether the cells build healthy tissue or fuel disease 🧪 doi.org/10.1038/s416...

doi.org

Postnatal sustentacular cells as chromaffin progenitors and tumor cells of origin in VHL-related paragangliomas - npj Precision Oncology

npj Precision Oncology - Postnatal sustentacular cells as chromaffin progenitors and tumor cells of origin in VHL-related paragangliomas

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Schlisio_lab @schlisio-lab.bsky.social · 22/07/2025

5/ DLK1-NOTCH signaling emerges as a key axis in chromaffin–sustentacular cell communication. DLK1 may act as a therapeutic vulnerability in PPGL.

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Schlisio_lab @schlisio-lab.bsky.social · 22/07/2025

4/ Some PPGL shows widespread SOX2 in PHOX2B+ tumor cells, linking SOX2 to stem-like states & impaired differentiation via ASCL1.

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Schlisio_lab @schlisio-lab.bsky.social · 22/07/2025

3/ In VHL-mutated paragangliomas, a subset of these sustentacular cells carries 3p loss—the hallmark of tumor cells—suggesting a shared clonal origin.

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Schlisio_lab @schlisio-lab.bsky.social · 22/07/2025

2/ These cells are distinct from embryonic neural crest and Schwann cell precursors and exhibit a unique progenitor signature, verified by in vivo lineage tracing & snRNA-seq.

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Schlisio_lab @schlisio-lab.bsky.social · 22/07/2025

1/ We identify SOX2+/SOX10+ sustentacular glia-like cells in mouse and human adrenal medulla & organ of Zuckerkandl as postnatal chromaffin progenitors.

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Schlisio_lab @schlisio-lab.bsky.social · 22/07/2025

Can support glia become cancer cells? Our study identifies SOX2⁺ postnatal chromaffin progenitors that may serve as tumor-initiating cells in paraganglioma. Figure 7 we inferring CNA from VHL related PPGL pre-neoplastic sustentacular cells sharing 3p deletions with tumor cells.

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Reposted by Schlisio_lab

Igor Adameyko @adameykolab.bsky.social · 21/06/2025

I worked a bit longer on my pink nudibranch video collection resulting from my Okinawa trip (visiting colleagues at OIST). Now the full video is on youtube: youtu.be/-YF9AQxVYS0?...

youtu.be

Cyerce kikutarobabai nudibranch from Okinawa

YouTube video by Igor Adameyko

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Reposted by Schlisio_lab

UlrikaKMarklund @ulrikakmarklund.bsky.social · 29/05/2025

Check out our new study on the innermost nervous system of the body—the submucosal plexus. We define three neuronal classes, map their connectivity, and uncover their stepwise development via phenotypic switching. Congrats to all authors! #NatureNeuroscience #EntericNervousSystem rdcu.be/eoqXz

rdcu.be

The transcriptomes, connections and development of submucosal neuron classes in the mouse small intestine

Nature Neuroscience - The neuronal composition of the intestinal submucosal plexus is incompletely understood. Here Li et al. define their neuron classes, connectome and stepwise acquisition of...

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Schlisio_lab @schlisio-lab.bsky.social · 09/03/2025

Painting of the week by my 13-year-old daughter

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