Accumulation of a biological material called lipofuscin is associated with aging and neurodegeneration. A new study uncovers a driver of this process.

Breakthrough ideas need more than a laboratory—they need a clear path to real-world impact. Since 2017, Yale University and the Blavatnik Family Foundation have partnered to accelerate promising disco...

Lipofuscin is an autofluorescent material that accrues in brain tissues with age and in Neuronal Ceroid Lipofuscinosis (NCL), a neurodegenerative disease with pediatric onset. The distribution, compos...

GBA, a major gene for Parkinson’s disease and dementia with Lewy bodies, is associated with increased risk of developing dementia. Here, we demonstrate that GBA mutations in mice contribute to cognitive deficits through α-synuclein-independent mechanisms that impact synaptic vesicle endocytosis.