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Savvides Lab

@savvideslab.bsky.social

218 followers 375 following 1 posts

The Savvides lab at the VIB-UGent Center for Inflammation Research (IRC) employs Integrative #StructuralBiology, including #crystallography and #cryoEM, to study proteins pivotal to inflammation, immunity and cancer.

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Reposted by Savvides Lab

Jan Felix @janfelix.bsky.social · 02/09/2025

Now published @cp-cellreports.bsky.social! Antibody-mediated TGF-β1 activation for the treatment of diseases caused by deleterious T cell activity: www.cell.com/cell-reports... Fantastic collaboration & massive effort from Sophie Lucas Lab @ de Duve Institute. #CryoEM with @savvideslab.bsky.social.

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Reposted by Savvides Lab

Jan Felix @janfelix.bsky.social · 10/07/2025

Finally out @natcomms.nature.com "Single-domain antibodies directed against hemagglutinin and neuraminidase protect against influenza B viruses". Great collab between @savvideslab.bsky.social (we performed #CryoEM) and Xavier Saelens Lab, spearheaded by Arne Matthys. www.nature.com/articles/s41...

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Savvides Lab @savvideslab.bsky.social · 13/04/2025

Delighted to share our reanalysis of cryo-EM data in EMPIAR-10930, now at: journals.plos.org/plosbiology/... ; revealing the ALK-ALKAL2 assembly with 2:1 stoichiometry and resolving the conundrum introduced by the originally reported 2:2 complex. ALK/LTK-cytokine signalling getting clearer!

journals.plos.org

Reanalysis of cryo-EM data reveals ALK-cytokine assemblies with both 2:1 and 2:2 stoichiometries

The mechanistic understanding of the complex between ALK kinase and its cytokine ligand ALKAL2 has been complicated by reports of diverse stoichiometries (2:1 vs 2:2). This study reanalyzes cryo-EM da...

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