Sign in

Samantha Graham

@samanthagraham.bsky.social
75 followers 63 following 16 posts

Postdoc at BWH/HMS investigating the multiomic landscape of COPD | she/her | spgraham1.github.io

PostsRepliesMedia
Samantha Graham @samanthagraham.bsky.social · 13/08/2026
I spend a lot of time thinking about this problem for myself--would adopting AI more broadly make me a more productive researcher, or would it keep me from developing the knowledge and skills I want to learn?
010
Reposted by Samantha Graham
Carl T. Bergstrom @carlbergstrom.com · 21/07/2026
1. We—@eduede.bsky.social, @mjcrockett.bsky.social, Kevin Gross, and I—have a new preprint on the arXiv today, based on ideas that emerged during an @sfiscience.bsky.social workshop in November 2024: The unintended consequences of large language models as a labor-augmenting technology in science.
arxiv.org
The unintended consequences of large language models as a labor-augmenting technology in science
As a labor-augmenting technology, large language models (LLMs) have the potential to accelerate scientific activity across the research pipeline. But even if LLMs perform on par with human experts at ...
10837338
Samantha Graham @samanthagraham.bsky.social · 26/05/2026
memorial day hike in the white mountains. The beautiful blue sky and views in the second pic lasted for all of 5 minutes of the 6+ hour hike 🙃
010
Reposted by Samantha Graham
Pamela Ferretti @pamferretti.bsky.social · 09/01/2026
Excited to share our new study out in Nature Communications. We mapped the composition of the human breast #milk #microbiome and showed that microbes present in breast milk directly contribute to the assembly of the #infant gut microbiome in the first months of life. www.nature.com/articles/s41...
nature.com
Client Challenge
34914
Samantha Graham @samanthagraham.bsky.social · 11/11/2025
why would I use snakemake when I can simply write a python script to write 51 job scripts and then write a for loop in bash to submit them?
010
Reposted by Samantha Graham
Ran Blekhman @blekhman.bsky.social · 05/11/2025
🧬 🦠 🏙️ Urban vs rural lifestyles create dramatically different gut microbiomes. But how do these different gut microbiomes affect the host? Excited to share our new paper: www.biorxiv.org/content/10.1...
23612
Reposted by Samantha Graham
Ran Blekhman @blekhman.bsky.social · 18/06/2025
Another review from my lab out this week, on analyzing gut microbiome data from global populations -- tackling computational challenges and providing practical frameworks and resources for the field With Sabrina Arif, @richabdill.com, @samanthagraham.bsky.social www.cell.com/trends/micro...
cell.com
Analyzing human gut microbiome data from global populations: challenges and resources
Research on the human gut microbiome is expanding rapidly; yet, most published studies focus on populations from high-income regions such as North America and Europe. Underrepresentation of population...
12210
Reposted by Samantha Graham
Pamela Ferretti @pamferretti.bsky.social · 04/06/2025
Interested in microbiome GWAS and heritability studies? Check out our new Review in Nature Reviews Genetics! We explore key findings, challenges, and future directions of the field. rdcu.be/epoRR @blekhman.bsky.social @sambhawa.bsky.social and Dr. Kelsey Johnson.
rdcu.be
Genomics of host–microbiome interactions in humans
Nature Reviews Genetics - In this Review, Ferretti et al. discuss advances in our understanding of interactions between the human genome and the microbiome, including the effects of the microbiome...
34927
Reposted by Samantha Graham
Rich Abdill @richabdill.com · 19/05/2025
We wrote up the process we've developed for processing microbiome data in bulk! Workflow management tools are miraculous for processing a project with lots of samples, but when you have lots of *projects* too, as we do when pulling data from NCBI databases, it gets hard to juggle. #microbiomesky
arxiv.org
Compendium Manager: a tool for coordination of workflow management instances for bulk data processing in Python
Compendium Manager is a command-line tool written in Python to automate the provisioning, launch, and evaluation of bioinformatics pipelines. Although workflow management tools such as Snakemake and N...
185
Reposted by Samantha Graham
Pamela Ferretti @pamferretti.bsky.social · 26/02/2025
Last week @richabdill.com and @samanthagraham.bsky.social's paper was featured on the cover of Cell! The cover, portraying microbes on shelves shaped like a world map, was possible thanks to the amazing team of illustrators at SciStories ✏️🦠
1146
Reposted by Samantha Graham
Ran Blekhman @blekhman.bsky.social · 20/02/2025
These are challenging times for science, but I'm happy to share a bright moment: our work is on the cover of Cell today. We built a compendium of human gut microbiomes integrating 168K worldwide samples, revealing patterns of microbiome variation across the globe www.cell.com/cell/current...
414326
Reposted by Samantha Graham
Ran Blekhman @blekhman.bsky.social · 24/01/2025
Use the Human Microbiome Compendium data! We made the data and code available, & created a website and R package to navigate the compendium. Links: - Website: microbiomap.org - Data: zenodo.org/records/1373... - R package: blekhmanlab.github.io/MicroBioMap/ - Code: github.com/blekhmanlab/...
microbiomap.org
Human Microbiome Compendium
An ongoing project to build a dataset of the human microbiome at an unprecedented scale.
25522
Samantha Graham @samanthagraham.bsky.social · 23/01/2025
Thank you! Yes, we're planning on continuing to process new data on SRA and update the resource
010
Samantha Graham @samanthagraham.bsky.social · 22/01/2025
Thanks to our many collaborators who made this possible! This has been a huge effort from our lab and others, and we couldn’t have done it without all who helped.
140
Samantha Graham @samanthagraham.bsky.social · 22/01/2025
We hope this is a useful resource for the microbiome community. Links below! Paper: www.cell.com/cell/fulltex... Dataset: doi.org/10.5281/zeno... Website: microbiomap.org Code: github.com/blekhmanlab/...
cell.com
Integration of 168,000 samples reveals global patterns of the human gut microbiome
The Human Microbiome Compendium is a unified database of publicly available human gut microbiome 16S samples, built with the integrated data from hundreds of independent projects. The compendium is us...
272
Samantha Graham @samanthagraham.bsky.social · 22/01/2025
Altogether, this dataset shows us how microbiomes differ throughout the world, and emphasizes the importance of more even sampling moving forward. We’re excited to continue learning from the compendium, and we plan to continue to process more samples to keep it up to date with the available data.
141
Samantha Graham @samanthagraham.bsky.social · 22/01/2025
The method of DNA extraction also has a strong effect on microbiome composition. But we found that a sample’s geographic location has a bigger effect on its alpha diversity than amplicon choice or the use of bead beating, a common technique in DNA extraction.
140
Samantha Graham @samanthagraham.bsky.social · 22/01/2025
In addition to biological differences between samples, there are technical factors that can affect microbiome composition. Does the region of the 16S gene that was sequenced affect our observed results? Yes! We found genera that were differentially abundant between amplicons.
130
Samantha Graham @samanthagraham.bsky.social · 22/01/2025
And because microbiomes from these regions are so different, we were able to train one-vs-all random forest classifiers to successfully predict where a microbiome sample came from.
110
Samantha Graham @samanthagraham.bsky.social · 22/01/2025
And specifically, we wanted to know what microbes were driving these large differences between world regions. We found that dozens of genera differ in abundance! Taxa like Bacteroides and Prevotella differ the most, but we found that every genus tested differed between at least two regions.
140
Samantha Graham @samanthagraham.bsky.social · 22/01/2025
With sampling so unbalanced, are we missing a lot of information? To answer this, we wanted to see how much microbiomes differ between world regions. This big PCoA plot showed us that microbiomes from around the world have pretty drastic differences in composition.
140
Samantha Graham @samanthagraham.bsky.social · 22/01/2025
We previously found that microbiome sampling is unevenly distributed throughout the world (journals.plos.org/plosbiology/...), and we wanted to quantify just how uneven it is. Over half of our samples come from Europe/N. America, seen in this map that’s distorted to show sampling imbalance.
141
Samantha Graham @samanthagraham.bsky.social · 22/01/2025
There’s tons of publicly available microbiome data, but this comes from 100s of studies that were processed separately, so we can’t directly compare results. We wanted to leverage this wealth of data, so we reprocessed raw data from 482 studies–that’s 5.7 terabases of data from all over the world!
160
Samantha Graham @samanthagraham.bsky.social · 22/01/2025
We’re thrilled that our first paper on the Human Microbiome Compendium, an integrated dataset of over 168,000 uniformly processed human gut microbiome samples, is officially out today in Cell! @richabdill.com @blekhman.bsky.social www.cell.com/cell/fulltex...
cell.com
Integration of 168,000 samples reveals global patterns of the human gut microbiome
The Human Microbiome Compendium is a unified database of publicly available human gut microbiome 16S samples, built with the integrated data from hundreds of independent projects. The compendium is us...
310044
Samantha Graham @samanthagraham.bsky.social · 06/12/2024
attempting to start posting on here as I (hopefully) wrap up my PhD in the next several months, both about science and my one true passion--taking pictures of peanut butter sandwiches on hikes
020