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Jeff Sperry

@safechem79.bsky.social
567 followers 289 following 70 posts

Director, Process Chemistry at Vertex Pharma (Boston) | Process Safety | High-Throughput Experimentation (HTE) | Oligonucleotides | views my own

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Reposted by Jeff Sperry
Scott Bagley @bagphos.bsky.social · 11/07/2026
This seems a good prompt for your annual reminder to avoid azide reactions in DCM #ChemSky #ChemChat
pubs.acs.org
Diazidomethane Explosion
An explosion that caused extensive damage to a 20-L rotary evaporator and nearby equipment in a kilo laboratory was determined to have been caused by diazidomethane accumulated in the condenser. Facto...
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Jeff Sperry @safechem79.bsky.social · 24/02/2026
A loooong journey to this: Energetics, Shock Sensitivity, and Thermal Hazards of Cubane and Bicyclo[1.1.1]pentane Derivatives | Organic Process Research & Development pubs.acs.org/doi/10.1021/...
pubs.acs.org
Energetics, Shock Sensitivity, and Thermal Hazards of Cubane and Bicyclo[1.1.1]pentane Derivatives
Strained polycyclic ring structures such as cubanes and bicyclo[1.1.1]pentanes (BCPs) are gaining popularity as isosteres in the pharmaceutical and agrochemical industries. It has been previously repo...
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Jeff Sperry @safechem79.bsky.social · 27/02/2025
Any experienced peptide chemists out there looking for a new challenge? I have an opening on my team vrtx.wd5.myworkdayjobs.com/en-US/vertex...
vrtx.wd5.myworkdayjobs.com
Process Chemistry Senior Principal Scientist, Synthetic Peptide Chemist
Job Description General Summary: Vertex is seeking an experienced peptide chemist to join the Process Chemistry group. In this lab-based position you will be responsible for the synthesis, purificatio...
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Jeff Sperry @safechem79.bsky.social · 03/02/2025
Huge loss for the chemistry community. Absolutely loved my time at UPenn. I wouldn’t be where I am today if it wasn’t for Amos’ mentorship and the friends I made in the group
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Reposted by Jeff Sperry
Jake Janey @phlogiston1.bsky.social · 27/12/2024
If you care about visualization of scientific data and creating clear, impactful scientific publications, I highly recommend this podcast featuring my esteemed colleague Bang Wong. He also has a fantastic set of papers on this topic #DataVisualization www.buzzsprout.com/558574/episo...
buzzsprout.com
S5E6: Writing Impactful Publications - NINDS's Building Up the Nerve
In the fifth Season of the National Institute of Neurological Disorders and Stroke’s Building Up the Nerve podcast, we help you strengthen your science communication skills with tools and advice to us...
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Jeff Sperry @safechem79.bsky.social · 13/12/2024
Probably my most controversial fb post (back when I actually used fb)
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Jeff Sperry @safechem79.bsky.social · 04/12/2024
Me trying In and Out for the first time
media.tenor.com
a man in a blue shirt is talking to a woman in a brooklyn nine-nine episode .
ALT: a man in a blue shirt is talking to a woman in a brooklyn nine-nine episode .
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Jeff Sperry @safechem79.bsky.social · 28/11/2024
My favorite line when recruiting for process chem:
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Reposted by Jeff Sperry
Derek Lowe @dereklowe.bsky.social · 26/11/2024
The long and ugly story of Cassava Sciences’ supposed Alzheimer’s drug simufilam is finally over. It should have ended well before this.
science.org
The Cassava Saga Finally Ends
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Reposted by Jeff Sperry
Keith Hornberger @krhornberger.bsky.social · 23/11/2024
Skeetorial time! Let’s talk early human dose prediction. Not the fancy, need-tons-of-software and a DMPK pro kind. Just the kind that uses some basic algebra. HDP is a unifying concept for med chemists. It’s the master optimization parameter, and it can’t be easily cheated. 1/
media.tenor.com
a pink background with pills and capsules on it
ALT: a pink background with pills and capsules on it
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Jeff Sperry @safechem79.bsky.social · 22/11/2024
Thank you @kcortiz.bsky.social
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Reposted by Jeff Sperry
Scott Bagley @bagphos.bsky.social · 15/11/2024
Created a Starter Pack for Industry Chemists- let me know if you want in! #ChemSky
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Reposted by Jeff Sperry
Keith Hornberger @krhornberger.bsky.social · 13/11/2024
Hard agree with all of this. Basic setting up of profile with pic and bio increases confidence in identity. Not that accounts can’t be spoofed, but it’s a start. My follows are flooded these last few days and I know I’m doing a lousy job of follow-backs. Help me know you’re you!
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Reposted by Jeff Sperry
Scott Bagley @bagphos.bsky.social · 10/11/2024
PSA for #ChemSky
Travis Kelce yelling at his coach with an important lab safety message “Don’t use sodium hydride in DMF or DMSO”
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Jeff Sperry @safechem79.bsky.social · 08/11/2024
Love seeing my followers drop on X
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Jeff Sperry @safechem79.bsky.social · 19/12/2023
Anybody going to CO for fall ACS?
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Reposted by Jeff Sperry
Brendan @chemscrapes.bsky.social · 07/12/2023
Getting into festive spirit with some chem Christmas carols. #chemsky #nmr #chemistry #science #christmas
An nmr spectrometer standing by the water. 3 ships are sailing in. Their sails read “Z1” “Z2” and “Z3”. The spectrometer is singing “I saw three shims come sailing in on Christmas Day, on Christmas Day”.
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Jeff Sperry @safechem79.bsky.social · 04/12/2023
THE REACTION IS SAFE IF RUN IN A SEALED VIAL!
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Jeff Sperry @safechem79.bsky.social · 25/10/2023
I started two manuscripts this week and I feel very academic
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Jeff Sperry @safechem79.bsky.social · 21/10/2023
Reskeet with how people would know if you suddenly became rich
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Reposted by Jeff Sperry
Keith Hornberger @krhornberger.bsky.social · 20/10/2023
Next for #NationalChemistryWeek ⚛️ (theme “The Healing Power of Chemistry”), here are some things I think are true that I’ve distilled about drug discovery over time. This series was originally posted on the other app and was livelier with GIFs, but I’ll record them here anyway.
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Jeff Sperry @safechem79.bsky.social · 25/09/2023
5+ hr flight and no one sitting beside me
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Jeff Sperry @safechem79.bsky.social · 20/09/2023
This is the first time I’ve been asked to review a paper where the chemistry actually blows my mind. Very cool stuff
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Jeff Sperry @safechem79.bsky.social · 10/09/2023
Using an image, show a movie you are sure you have watched more than 10 times
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Jeff Sperry @safechem79.bsky.social · 19/08/2023
Chemists working with stannanes in the 1960s
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Jeff Sperry @safechem79.bsky.social · 18/08/2023
Maybe a little late to this party but thanks for the invite @chemjobber.bsky.social 👊🏻
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