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Science for ME (S4ME)

@s4me.info

1.9K followers 28 following 983 posts

We're an independent, patient-led, international discussion forum (www.s4me.info) for people with ME/CFS and carers, clinicians, scientists and advocates who support us. Facts about ME/CFS: www.s4me.info/threads/science-for-m…

Posts Replies Media

Science for ME (S4ME) @s4me.info · 6h

Dysautonomia and Postural Orthostatic Syndrome of Hypocapnia in Long COVID Syndrome — O’Brien et al "Patients from this cohort with LCS, dysfunctional breathing and hypocapnia based on the lean test were referred for targeted pulmonary rehab." #MECFS

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Science for ME (S4ME) @s4me.info · 10h

Hair cortisol concentration and basal heart rate variability differentiate long COVID from depressive disorders in youth — Oehlke et al #MECFS

sciencedirect.com

Science for ME (S4ME) @s4me.info · 12h

Remnant virus proteins sustain vascular inflammation post coronavirus infection in mice and humans. — Gibler et al #MECFS

portlandpress.com

Science for ME (S4ME) @s4me.info · 17h

Characterizing Host Inflammatory Bioprofiles in People With Postacute Sequelae SARS-CoV-2 Infection (PASC) — Marmont et al #MECFS

onlinelibrary.wiley.com

Science for ME (S4ME) @s4me.info · 20h

Neurocognitive Indices of Long COVID: Dysregulated Engagement of Inhibitory Control and Oscillatory Slowing — White et al #MECFS

Science for ME (S4ME) @s4me.info · 05/10/2026

Brain-binding auto-antibodies in subjects with and without post-COVID-syndrome after SARS-CoV-2 infection — Faraj et al #MECFS

sciencedirect.com

Science for ME (S4ME) @s4me.info · 05/10/2026

Autoantibody landscapes in Long COVID with neurological symptoms show heterogeneity without a shared disease signature — Chakravarty et al #MECFS

insight.jci.org

Science for ME (S4ME) @s4me.info · 05/10/2026

Pharmacological Treatment Approaches in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) — Habermann-Horstmeier #MECFS

Science for ME (S4ME) @s4me.info · 05/10/2026

The importance of work: A qualitative study of primary carers of severe ME patients’ experiences of balancing work with comprehensive caregiving responsibilities — Størdal and Iversen #MECFS

sciencedirect.com

Science for ME (S4ME) @s4me.info · 05/10/2026

🧵 of highlighted #MECFS and #LongCovid research papers discussed in the last week on the Science for ME forum. 28 Sep - 4 Oct 2026

Science for ME (S4ME) @s4me.info · 04/10/2026

Our latest News in Brief summary has headlines and links to further reading about ME/CFS, Long Covid, and related news for the week of Sept. 28 - Oct 4: s4me.info/threads/news... #MEcfs #PwME #LongCovid #PwLC

News in Brief - September 2026

This thread has a Science for ME 'News in Brief' post for each week in September 2026 by a team including @Trish, @Kalliope, @ahimsa and @SNT Gatchaman. Scroll down to see this week's news.

Science for ME (S4ME) @s4me.info · 29/09/2026

An Open-Label Feasibility Study of Remdesivir in Long COVID: Results from the ERASE LC Trial — Faghy et al "The mean (SD) distance achieved in the 6MWT was 408 (113) metres at baseline compared to 468 (109) metres post-intervention" #MECFS

Science for ME (S4ME) @s4me.info · 29/09/2026

The role of 6-minute walk test and pulmonary function testing in patients with post COVID-19 condition: a systematic review and meta-analysis — Khawandi et al "The overall certainty of the evidence was very low due to the high risk of bias, indirectness, and imprecision." #MECFS

Science for ME (S4ME) @s4me.info · 29/09/2026

Booster dose of COVID-19 vaccine and its effectiveness against post COVID-19 condition in individuals with pre-existing immunity: a sequential propensity score-matched cohort study — Morris et al #MECFS

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Science for ME (S4ME) @s4me.info · 29/09/2026

Serum NfL and GFAP in post-COVID syndrome: minimal evidence of CNS injury after adjusting for confounders — Wunderle et al "[ME/CFS] was present in 61.4% of PCS and absent in controls" #MECFS

frontiersin.org

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Science for ME (S4ME) @s4me.info · 29/09/2026

A systems microbiology framework for reproducible multi-dataset omics integration with application to long COVID — Varga et al #MECFS

frontiersin.org

Science for ME (S4ME) @s4me.info · 29/09/2026

The Post-Acute Effects of COVID-19 Are Not Associated with Robust Long-Term Regional or Global Brain Volumetric Changes: A Bayesian Meta-Analytic Evidence — Costa et al #MECFS

sciencedirect.com

Science for ME (S4ME) @s4me.info · 29/09/2026

Clinical Symptomatology, Cognition and Psychosocial Wellbeing in Adolescents With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Cross-Sectional Observational Study — Chau et al #MECFS

onlinelibrary.wiley.com

Science for ME (S4ME) @s4me.info · 29/09/2026

DNA methylation: unifying framework for complex chronic conditions — Sharma et al Review. #MECFS

Science for ME (S4ME) @s4me.info · 28/09/2026

Role of haptoglobin and its phenotypic variations in the pathophysiology of myalgic encephalomyelitis and long COVID — Moezzi PhD thesis. #MECFS

umontreal.scholaris.ca

Science for ME (S4ME) @s4me.info · 28/09/2026

Evaluation of an Integrated Multidisciplinary Care Model for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Open-label, Non-randomized Controlled Intervention Study — Peters et al #MECFS

Science for ME (S4ME) @s4me.info · 28/09/2026

Hemodynamic Phenotyping in ME/CFS and ANOCA: Complementary Insights from Coronary Function Testing and Invasive Cardiopulmonary Exercise Testing — Mackay et al #MECFS

journals.physiology.org

Science for ME (S4ME) @s4me.info · 28/09/2026

🧵 of highlighted #MECFS and #LongCovid research papers discussed in the last week on the Science for ME forum. 21 - 27 Sep 2026

Science for ME (S4ME) @s4me.info · 27/09/2026

Our latest News in Brief summary has headlines and links to further reading about ME/CFS, Long Covid, and related news for the week of Sept. 21 - 27. s4me.info/threads/news... #MEcfs #PwME #LongCovid #PwLC

News in Brief - September 2026

This thread has a Science for ME 'News in Brief' post for each week in September 2026 by a team including @Trish, @Kalliope, @ahimsa and @SNT Gatchaman. Scroll down to see this week's news.

Reposted by Science for ME (S4ME)

Robert Saunders (aka McMullen) @roberthmcmullen.bsky.social · 21/09/2026

The S4ME forum has started a thread for members to share stories of their ME/CFS journeys in up to 10 sentences: s4me.info/threads/your... The WE&ME foundation will ask some contributors if they can use their stories for advocacy. This is my story. Please consider sharing yours on @s4me.info

Once an academic scholar and keen sportsman, my ME/CFS symptoms came on suddenly in 1992 when I was a 19 year old student, following tonsillitis, suspected glandular fever and two courses of antibiotics. The transition from someone who was essentially well and able to participate in normal activities to someone who was very obviously unwell and incapacitated was marked and sudden. However, I suspect that there may have been something wrong with me prior to that as I had been unusually tired and prone to infections for a few years, along with unidentified problems in my knee and shoulder, which had limited my ability to run and play racket sports.

After struggling to live independently on and off for about 18 months, I returned to live with my parents fulltime in 1994. If I had known then what lay ahead, I would not have been able to cope, and I don’t know if I would still be alive. For about seven years I was almost completely bedridden, in excruciating discomfort, urinating into a bottle and eating meals in bed. Now aged 53 I am mostly housebound and cared for by my 80 year old mother in a wheelchair adapted annexe on the side of her house.

One can be philosophical about loss and incapacity – about absence – but there is no philosophy that can overcome the presence of extreme physical discomfort and pain; of constantly feeling unwell. I am luckier than many people with my diagnosis in that some of my family and friends have been extremely supportive, and I have had some kind and helpful doctors, but like most people with ME/CFS I have also been let down, mistreated, ridiculed and abused, both personally and institutionally.

Love, solidarity and productivity, however limited, help to get me through the days, but I’m not sure that I could keep going without hope – hope of scientific understanding and a better quality of life.

Science for ME (S4ME) @s4me.info · 21/09/2026

Bidirectional Associations Between Autonomic Function, Sleep Quality, and Daily Fatigue and Energy Symptoms in Long COVID: Longitudinal Digital Health Study — Aboagye et al. #MECFS

cardio.jmir.org

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Science for ME (S4ME) @s4me.info · 21/09/2026

Comparative Analysis of Circulating Cytokines and Adrenergic Autoantibodies in Postural Orthostatic Tachycardia Syndrome, Postacute Sequelae of SARS‐CoV‐2, and Healthy Controls — Seeley et al #MECFS

ahajournals.org

Science for ME (S4ME) @s4me.info · 21/09/2026

Association of mRNA SARS-CoV-2 vaccination with fatigue and functional recovery in patients with post-acute sequelae of COVID-19 (PASC) — Pries et al "Adults with […] PASC and at least two visits 3 to 6 months apart […] were eligible." #MECFS

tandfonline.com

Science for ME (S4ME) @s4me.info · 21/09/2026

Longitudinal epigenetic rewiring in lung immune cells in patients with post COVID-19 condition — Nikesjö et al #MECFS

link.springer.com

Science for ME (S4ME) @s4me.info · 21/09/2026

Cognitive fatigue is related to reduced cerebral perfusion and sustained attention in patients with post COVID-19 condition: An fMRI study — Hedberg et al #MECFS

sciencedirect.com

Science for ME (S4ME) @s4me.info · 20/09/2026

FreeSurfer-based amygdala subfield volumetry: in long COVID and ME/CFS: clinical and immunological correlations — Kimura et al "No group difference or partial correlation remained significant after correction for multiple testing." #MECFS

frontiersin.org

Science for ME (S4ME) @s4me.info · 20/09/2026

Our latest News in Brief summary has headlines and links to further reading about ME/CFS, Long Covid, and related news for the week of Sept. 14 - 20. s4me.info/threads/news... #MEcfs #PwMe #LongCovid #PwLC

News in Brief - September 2026

This thread has a Science for ME 'News in Brief' post for each week in September 2026 by a team including @Trish, @Kalliope, @ahimsa and @SNT Gatchaman. Scroll down to see this week's news.

Science for ME (S4ME) @s4me.info · 20/09/2026

Seven replicated genomic associations: of myalgic encephalomyelitis/chronic fatigue syndrome a biobank study — Slaughter et al #MECFS

Science for ME (S4ME) @s4me.info · 20/09/2026

🧵 of highlighted #MECFS and #LongCovid research papers discussed in the last week on the Science for ME forum. 14 - 20 Sep 2026

Science for ME (S4ME) @s4me.info · 14/09/2026

Comparison of new and recurring post-acute infection syndrome – results from a German population-based cohort — Frost et al #MECFS

Science for ME (S4ME) @s4me.info · 14/09/2026

A brief report: absence of elevated circulating NETosis markers in long-term long COVID — Humer et al "Plasma levels of MPO-DNA, histone-DNA and citrullinated histone H3 (H3) did not differ significantly between LC and HC." #MECFS

frontiersin.org

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Science for ME (S4ME) @s4me.info · 14/09/2026

Microvascular Dysfunction and Redox Imbalance in Long COVID — Lewandowska et al "We observed a reduced erythrocyte NAD+/NADH ratio and lower NADP concentrations" #MECFS

onlinelibrary.wiley.com

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Science for ME (S4ME) @s4me.info · 14/09/2026

Myalgic encephalomyelitis/chronic fatigue syndrome and overlapping post-acute infection syndromes: international expert consensus framework for diagnostic standardization — Kujawski et al #MECFS

link.springer.com

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Science for ME (S4ME) @s4me.info · 14/09/2026

Postural orthostatic tachycardia syndrome in adolescents with ME/CFS — a case control study — Leone et al Pilot. #MECFS

frontiersin.org

Science for ME (S4ME) @s4me.info · 14/09/2026

Total blood volume and red blood cell volume are not associated with orthostatic intolerance in adults with myalgic encephalomyelitis/chronic fatigue syndrome — Yamazaki et al #MECFS

physoc.onlinelibrary.wiley.com

Science for ME (S4ME) @s4me.info · 13/09/2026

Our latest News in Brief summary has headlines and links to further reading about ME/CFS, Long Covid, and related news for the week of Sept. 7 - 13. s4me.info/threads/news... #MEcfs #PwME #LongCovid #PwLC

News in Brief - September 2026

This thread has a Science for ME 'News in Brief' post for each week in September 2026 by a team including @Trish, @Kalliope, @ahimsa and @SNT Gatchaman. Scroll down to see this week's news.

Science for ME (S4ME) @s4me.info · 13/09/2026

🧵 of highlighted #MECFS and #LongCovid research papers discussed in the last week on the Science for ME forum. 7 - 13 Sep 2026

Science for ME (S4ME) @s4me.info · 07/09/2026

Case Report: Post-Mortem Analysis of Long-Term Inflammation After Mild COVID-19 — Wu et al #MECFS

frontiersin.org

Science for ME (S4ME) @s4me.info · 07/09/2026

Measurement properties of the 30-second sit-to-stand test in post COVID-19 condition: Results from the PYCNOVID randomised controlled trial — Braun et al #MECFS

journals.plos.org

Science for ME (S4ME) @s4me.info · 07/09/2026

Microbiome dysbiosis in long COVID: a scoping review of mechanistic insights, symptom associations, and therapeutic targets — Cano-Cevallos et al #MECFS

link.springer.com

Science for ME (S4ME) @s4me.info · 07/09/2026

Persistent fibroblast-related tissue activity in long COVID after moderate-to-severe acute COVID-19 assessed by [⁶⁸Ga]Ga-FAPI PET/CT — Hasan et al #MECFS

sciencedirect.com

Science for ME (S4ME) @s4me.info · 07/09/2026

Using hyperpolarised xenon magnetic resonance imaging to explore breathlessness in long COVID: results from the EXPLAIN study — Ng et al #MECFS

publications.ersnet.org

Science for ME (S4ME) @s4me.info · 07/09/2026

Disabling Dynamics: Long Covid and the Challenges of Securitizing Slow-Onset Health Threats — Finkelstein #MECFS

link.springer.com

Science for ME (S4ME) @s4me.info · 07/09/2026

Registered interventional trials fail to cover patient-prioritised treatments in Post-COVID condition (PCC) — Gabriel et al #MECFS

researchsquare.com

Science for ME (S4ME) @s4me.info · 07/09/2026

Impaired Auditory Sensory Gating as a Neurophysiological Correlate of Cognitive Fatigue in Long COVID — Mischke and Zaehle "The results showed that auditory sensory gating accounted for unique variance in cognitive fatigue beyond the effects of depressive symptoms and demographic factors." #MECFS

psycnet.apa.org