iiinova — where your digital self keeps evolving

RyanLab_TCD @ryanlab.bsky.social · 23/09/2026

📢Last weeks #immunometabolism discoveries mitoworld.org @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting highlight: ENPP1 buffers extracellular cGAMP in brown adipose tissue to limit insulin resistance Cell Press

022

RyanLab_TCD @ryanlab.bsky.social · 14/09/2026

📢 Last weeks #immunometabolism discoveries Biomed News mitoworld.org ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: Glutamine-dependent biosynthetic pathways fuel autoreactive T and B cells in Foxp3 deficiency–mediated disease

151

RyanLab_TCD @ryanlab.bsky.social · 07/09/2026

📢 Last weeks #immunometabolism discoveries Biomed News mitoworld.org ⬇️ ⬇️ ⬇️ biomed.news/bims-imicid/... Interesting finding: SDH inhibition quenches rheumatoid arthritis flare-associated IL-1β+IFN-γ+ macrophages via NF-κB/STAT4 #mitochondria

010

RyanLab_TCD @ryanlab.bsky.social · 27/07/2026

📢 Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️ ⬇️ ⬇️ biomed.news/bims-imicid/... Interesting finding: The Legionella pneumophila effector SidL is an adenylyltransferase that modifies the glycolytic intermediate 3-phosphoglycerate

012

RyanLab_TCD @ryanlab.bsky.social · 29/06/2026

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: Disrupted mitochondrial dynamics activate RNA-sensing innate immunity through mitochondrial RNA release

033

RyanLab_TCD @ryanlab.bsky.social · 25/06/2026

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting findings: I) Comparative Interactome Profiling of Itaconate and α-KG by the PELSA II) Plasmacytoid DCs Exhibit High Transferrin Receptor Expression Without Iron Accumulation

132

RyanLab_TCD @ryanlab.bsky.social · 15/06/2026

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting paper: Met-Vision reveals coexisting energetic states in tissue macrophages redistributed by inflammation

143

RyanLab_TCD @ryanlab.bsky.social · 09/06/2026

📢 Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️ ⬇️ ⬇️ biomed.news/bims-imicid/... Interesting finding: Mitochondrial OXPHOS restricts SARS-CoV-2 replication #mitochondria

162

RyanLab_TCD @ryanlab.bsky.social · 01/06/2026

📢 Last 2 weeks of #immunometabolism discoveries brought to you from EUROMIT 2026 in sunny Angers Saint-Laud ☀️ @biomednews.bsky.social ⬇️ ⬇️ ⬇️ biomed.news/bims-imicid/... biomed.news/bims-imicid/... Interesting finding: Monocyte infiltration induces CNS arginine catabolism to fuel neuroinflammation

152

RyanLab_TCD @ryanlab.bsky.social · 17/05/2026

📢 Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: Epigenetic reprogramming of T cell metabolism restores function and enhances anti-tumor immunity in lung cancer

062

RyanLab_TCD @ryanlab.bsky.social · 16/05/2026

#Mitochondria serve as a holdout compartment for aggregation-prone proteins hindering efficient degradation www.nature.com/articles/s41...

065

RyanLab_TCD @ryanlab.bsky.social · 12/05/2026

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: Triose phosphate isomerase 1 remodels mitochondrial cristae ultrastructure to rewire microglial immunometabolism against ischemic stroke

093

RyanLab_TCD @ryanlab.bsky.social · 07/05/2026

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: Metabolic and transcriptional plasticity supports CD8+ T cell resilience and anti-tumor immunity under nutrient stress.

032

RyanLab_TCD @ryanlab.bsky.social · 27/04/2026

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding - an 'immune-independent' function of B cells! B cell deficiency limits exercise capacity by remodeling liver glutamate metabolism

023

RyanLab_TCD @ryanlab.bsky.social · 20/04/2026

📢Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️ biomed.news/bims-imicid/... Lot's of exciting findings! 1) Purine salvage pathway protects CD8+ T cells from metabolic stress 2) Mitochondrial metabolism regulates the immunogenic responsiveness of dendritic cells

043

RyanLab_TCD @ryanlab.bsky.social · 12/04/2026

📢last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: iNOS modulates inflammatory responses in an NO-independent manner through direct interaction with IRG1 in mitochondria.

0106

RyanLab_TCD @ryanlab.bsky.social · 07/04/2026

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: Mitochondrial ATP production promotes T cell differentiation and function by regulating chromatin accessibility

053

RyanLab_TCD @ryanlab.bsky.social · 31/03/2026

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting new 'immunometabolism' method: Single-cell assessment of iron content in primary human T cells using laser ablation inductively coupled plasma mass spectrometry

097

RyanLab_TCD @ryanlab.bsky.social · 23/03/2026

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: Glycogen phosphorylase L confers metabolic flexibility in neutrophils to fight fungal infections in nutrient-deprived tissues

174

RyanLab_TCD @ryanlab.bsky.social · 19/03/2026

📢 Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: Macrophage anti-bacterial activity is controlled by adenylate kinase 4–mediated mitochondrial DNA synthesis

043

RyanLab_TCD @ryanlab.bsky.social · 08/03/2026

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: The glycolytic metabolite phosphoenolpyruvate restricts cGAS-driven inflammation to promote healthy aging.

076

RyanLab_TCD @ryanlab.bsky.social · 04/03/2026

📢last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting papers 🧪: I) The immunometabolic topography of cellular organization in TB II) The human antibacterial factor APOL3 couples lysosomal damage to mtDNA efflux and type I IFN induction.

054

RyanLab_TCD @ryanlab.bsky.social · 23/02/2026

📢Last weeks #immunometabolism discoveries 🧪@Bims_BiomedNews ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: Cis-aconitate therapy protects against influenza mortality by dual targeting of viral polymerase and ERK/AKT/NF-κB signaling #mitochondria #metabolites

Figure 9: Anti-influenza mechanism of action of cis-aco. DOI: 10.1038/s44321-026-00379-8.

144

RyanLab_TCD @ryanlab.bsky.social · 16/02/2026

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️ 🧪 biomed.news/bims-imicid/... Incl. I) Hormonal rewiring of immunity during DR ensures host defense & systemic glucose conservation II) Asparagine sensing by TBK1 controls phase separation to drive antiviral innate immune resp.

Graphical abstract from https://doi.org/10.1016/j.immuni.2026.01.003

Graphical abstract from https://doi.org/10.1016/j.molcel.2026.01.010

072

RyanLab_TCD @ryanlab.bsky.social · 10/02/2026

🔊Last 2 weeks of #immunometabolism discoveries @biomednews.bsky.social ⬇️ biomed.news/bims-imicid/... biomed.news/bims-imicid/... Interesting findings🧪: I) Enterococcus faecalis-derived lactic acid suppresses macrophage activation to facilitate persistent and polymicrobial wound infections

041

RyanLab_TCD @ryanlab.bsky.social · 26/01/2026

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: Spatiotemporal regulation of energetic charge dictates T cell function @natcomms.nature.com

054

RyanLab_TCD @ryanlab.bsky.social · 18/01/2026

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting paper: Metabolic adaptations rewire CD4+ T cells in a subset-specific manner in human critical illness with and without sepsis

0104

RyanLab_TCD @ryanlab.bsky.social · 12/01/2026

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: Albumin orchestrates a natural host defence mechanism against mucormycosis

073

RyanLab_TCD @ryanlab.bsky.social · 04/01/2026

📢Last weeks #immunometabolism report @biomednews.bsky.social hasn't come online so I'm highlighting this preprint from my selection: pmc.ncbi.nlm.nih.gov/articles/PMC... Mapping metabolic dependences and capacities using ATP as a biomarker - a new Flow Cytometry method to add to the toolkit

040

RyanLab_TCD @ryanlab.bsky.social · 28/12/2025

Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting paper: Activated T cells degrade extracellular proteins to enhance effector functions

085

RyanLab_TCD @ryanlab.bsky.social · 28/12/2025

Mitochondria-derived PEP licenses glycerolipid synthesis via SLC25A35 pubmed.ncbi.nlm.nih.gov/41446167/

0105

RyanLab_TCD @ryanlab.bsky.social · 23/12/2025

🎄Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️ biomed.news/bims-imicid/... A great Christmas selection inside! I) Gut microbiota promotes immune tolerance at the maternal-fetal interface

044

RyanLab_TCD @ryanlab.bsky.social · 14/12/2025

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️ biomed.news/bims-imicid/... Interesting findings: I) Dynamic changes in mitochondria support phenotypic flexibility of microglia II) Mitochondria are absent from microglial processes performing surveillance

0105

RyanLab_TCD @ryanlab.bsky.social · 11/12/2025

I had the pleasure of acting as an external PhD examiner for @aitorjarit.bsky.social in the lab of @sancholab.bsky.social 🇪🇸 during the summer. Today I received his PhD thesis and a beautiful gift of a mitochondria illustrated in the style of an Andalusian tile. Thank you very much!

0131

RyanLab_TCD @ryanlab.bsky.social · 07/12/2025

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: Cytochrome c oxidase dependent respiration is essential for T cell activation, proliferation and memory formation

0145

RyanLab_TCD @ryanlab.bsky.social · 05/12/2025

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... A huge collection inside! Interesting finding: Itaconate transport across the plasma membrane and Salmonella-containing vacuole via MCT1/4 modulates macrophage antibacterial activity

121

RyanLab_TCD @ryanlab.bsky.social · 23/11/2025

📢Last 2 weeks of #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️ biomed.news/bims-imicid/... biomed.news/bims-imicid/... Exciting to have a paper in the collection! An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice

0169

RyanLab_TCD @ryanlab.bsky.social · 10/11/2025

Last week's #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: Intracellular Salmonella hijacks the mitochondrial citrate carrier to evade host oxidative defenses

1104

RyanLab_TCD @ryanlab.bsky.social · 06/11/2025

Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis #mitochondria www.cell.com/molecular-ce...

040

RyanLab_TCD @ryanlab.bsky.social · 03/11/2025

Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: Quercetin-derived microbial metabolite DOPAC potentiates CD8+ T cell anti-tumor immunity via NRF2-mediated mitophagy

032

RyanLab_TCD @ryanlab.bsky.social · 28/10/2025

📢 last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Interesting finding: Bioenergetic reprogramming of macrophages reduces drug tolerance in Mycobacterium tuberculosis @NatureComms

021

RyanLab_TCD @ryanlab.bsky.social · 20/10/2025

Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Lots of excellent work inside incl. Backtracking metabolic dynamics in single cells predicts bacterial replication in human macrophages.

064

RyanLab_TCD @ryanlab.bsky.social · 12/10/2025

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Many highlights inside! incl. TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and Parkin-independent mitophagy

095

RyanLab_TCD @ryanlab.bsky.social · 05/10/2025

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Highlight: Acetyl-CoA carboxylase-1 inhibition increases regulatory T-cell metabolism and graft-vs-host disease treatment efficacy via mitochondrial fusion

074

RyanLab_TCD @ryanlab.bsky.social · 29/09/2025

Recently @natureportfolio.nature.com had an article about Bluesky being a better platform for sharing science than X. It hasn't been my experience to date. Same post yesterday had more engagement on X and LinkedIN. Wondering if it's domain specific? What are others experience?

130

RyanLab_TCD @ryanlab.bsky.social · 28/09/2025

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... Highlights: Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4.

0103

RyanLab_TCD @ryanlab.bsky.social · 17/09/2025

New cohort of @tcddublin.bsky.social Assitant Professors at our induction😀☘️

040

RyanLab_TCD @ryanlab.bsky.social · 15/09/2025

🔉Last weeks #immunometabolism discoveries @biomednews.bsky.social 🔽🔽🔽 biomed.news/bims-imicid/... Highlight: Macrophage metabolic reprogramming during dietary stress influences adult body size in Drosophila

053

RyanLab_TCD @ryanlab.bsky.social · 10/09/2025

📢Last 2 weeks of #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️ biomed.news/bims-imicid/... biomed.news/bims-imicid/... Highlight: Nrf2 drives activation-driven expansion of CD4+T cells by modulating glucose and glutamine metabolism

063