🔎 What are the consequences of hypermetabolism in human motor neurons?
Our new study from the @htyynismaa.bsky.social lab is out!
Using human iPSC-derived motor neurons, we show that increased energy demand drives key metabolic trade-offs.
🔗 www.nature.com/articles/s42...
nature.com
Metabolic costs and trade-offs of hypermetabolism in human motor neurons with ATP synthase deficiency - Communications Biology
Hypermetabolism results in the redistribution of acetyl-CoA usage, reduced histone acetylation, and potential vulnerabilities of motor neurons via altered maintenance of acetylcholine