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Ruoyan Li

@ruoyanli89.bsky.social
68 followers 90 following 1 posts

Assistant Professor at MD Anderson Cancer Center | Cancer genomics, single-cell genomics, and somatic evolution www.mdanderson.org/research/departm…

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Reposted by Ruoyan Li
Kamila Naxerova @naxerova.bsky.social · 06/05/2026
A gene is recurrently mutated in cancer. But do these mutations really cause the disease? Or are they merely selected during normal tissue evolution? Postdoc D. Cheek had the creative idea to use patient ages to try and answer this question. Read new paper out here: www.nature.com/articles/s41...
nature.com
Age distinguishes selection from causation in cancer genomes - Nature Genetics
Mutations may be enriched in tumor samples because they promote carcinogenesis or because they promote clonal expansions in healthy tissue. This study mathematically disentangles these two possibiliti...
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Reposted by Ruoyan Li
Tianshu @tianshu-sun.bsky.social · 01/09/2025
Excited to share that our latest work in New Phytologist: the first cell-type–resolved transcriptomic atlas for two dicot C4 models (G. gynandra & F. bidentis) with a single-protoplast vs single-nucleus comparison + an interactive gene-expression browser. nph.onlinelibrary.wiley.com/doi/10.1111/...
nph.onlinelibrary.wiley.com
Conserved spatial patterning of gene expression in independent lineages of C4 plants
C4 photosynthesis enhances carbon fixation efficiency by reducing photorespiration through the use of an oxygen-insensitive carboxylase and spatial separation of photosynthesis between mesophyll and ....
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Reposted by Ruoyan Li
Inigo Martincorena @imartincorena.bsky.social · 20/11/2024
Resharing here a recent X post. In this preprint, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/ www.medrxiv.org/content/10.1...
medrxiv.org
Somatic mutation and selection at epidemiological scale
As we age, many tissues become colonised by microscopic clones carrying somatic driver mutations ([1][1]–[10][2]. Some of these clones represent a first step towards cancer whereas others may contribu...
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Ruoyan Li @ruoyanli89.bsky.social · 22/11/2024
Thrilled to share our latest work on cutaneous T cell lymphoma. Check it out👇🏼 www.nature.com/articles/s41...
nature.com
Cutaneous T cell lymphoma atlas reveals malignant TH2 cells supported by a B cell-rich tumor microenvironment - Nature Immunology
Haniffa and colleagues provide diagnostic aids, potential biomarkers for disease staging and therapeutic strategies for cutaneous T cell lymphoma.
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