iiinova — where your digital self keeps evolving

Rui Castro @ruicastrohd.bsky.social · 07/05/2025

Leila Akkari herself spoke about the tumour microenvironment in the context of liver cancer evolution, with Serena Vegna delcing deeper into genetic differences affecting the TME

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Rui Castro @ruicastrohd.bsky.social · 07/05/2025

Excited for #EASLCongress 2025! 🤩 As always, starting with the Basic Science Seminar, this year on Liver Tumours, Exposomics and Personalized Therapies, organised by Leila Akkari, @boulterlab.bsky.social and Jesus Bañales @easlnews.bsky.social

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Rui Castro @ruicastrohd.bsky.social · 15/04/2025

BS @easlnews.bsky.social Congress Wed 7🗓️Whole-day seminar plus a wet lab on spatial biology (NEW THIS YEAR‼️) Thu 8🗓️State of the Art by Lars Zender Fri 9🗓️MTE sessions on MASLD & MetALD Sat 10🗓️Microbiome session co-chaired by our own @debbieshawcross.bsky.social & more!🔗https://tinyurl.com/4ky9r3x9

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Rui Castro @ruicastrohd.bsky.social · 08/04/2025

In HCC, eIF3f|ACSL4 was shown to promote tumour malignancy by promoting fatty acid biosynthesis, with its targeting increasing anti-PD-1 efficacy 👉https://www.journal-of-hepatology.eu/article/S0168-8278(25)00206-5/fulltext @jhepatology.bsky.social

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Rui Castro @ruicastrohd.bsky.social · 08/04/2025

2️⃣ translational studies on surpassing therapeutic resistance in liver cancer in press @jhepatology.bsky.social In CCA, cisplatin-induced INF2 degradation was identified as a mechanism of enhanced cisplatin resistance 👉https://journal-of-hepatology.eu/article/S0168-8278(25)00219-3/fulltext

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Rui Castro @ruicastrohd.bsky.social · 12/03/2025

In a related topic, more about MASLD in an amazing Nature Reviews Disease Primers article just published: 🔗 nature.com/articles/s41... @jvlazarus.bsky.social

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Rui Castro @ruicastrohd.bsky.social · 12/03/2025

📢EASL Studio today!👇 In the week celebrating #IWD2025, Saskia van Mil, Sara Della Torre & Münevver Demir will address mechanisms driving sex disparities in MASLD Tune in! 📺 🔗https://easl.eu/easl-studio-episode/s8e6/

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Rui Castro @ruicastrohd.bsky.social · 28/01/2025

& just published in @jhepatology.bsky.social 🧬Mitochondrial CMPK2 is upregulated in human & experimental MASH 📈Ensues disease progression through the Nlrp3 inflammasome & pyroptosis 💉Nordihydroguaiaretic acid is a novel CMPK2 inhibitor supressing MASH 📰 doi.org/10.1016/j.jh...

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Rui Castro @ruicastrohd.bsky.social · 25/01/2025

Great talk by YI E. Torrejón on how gut EV-kupffer cell interaction contributes to MASLD #SLDsummit HFD gut-EVs carry Selenocysteine Lyase (SCLY) to Kupffer cells, attenuating pro-inflammatory activity. It also activates ZEB2, inhibiting fibrogenesis @easlnews.bsky.social

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Rui Castro @ruicastrohd.bsky.social · 25/01/2025

Stijn Meijnikman on the role of auto-brewery 🍺🦠 in SLD The goal for the future is to use personalised medicine to eliminate high-ethanol-producing bacteria (gut microbiota transplantation, phages, antibiotics, pre|probiotics) @easlnews.bsky.social #SLDsummit @debbieshawcross.bsky.social #Liversky

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Rui Castro @ruicastrohd.bsky.social · 25/01/2025

Martinez-Chantar addresses potential mitochondria-targeting therapies in MASLD, focusing on: 🎯 Methylation-controlled J protein (MCJ) 🎯 Glutaminase 1 (GLS1) 🎯 Mg2+ transporter CNNM4 using GalNAc-siRNA conjugates 💉 @easlnews.bsky.social #SLDsummit #Liversky

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Rui Castro @ruicastrohd.bsky.social · 25/01/2025

Another great study, this time by Jerôme Eeckhoute: what drives hepatocyte-cholangiocyte transdifferentiation? 🔎 One requirement appears to be relieving epigenetic repression of cholangiocyte genes in hepatocytes ❗️

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Rui Castro @ruicastrohd.bsky.social · 25/01/2025

Agree! 👌🏼 Very interesting also to see several recent studies clustering patients based on extrahepatic complications and how this may help prognosis

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Rui Castro @ruicastrohd.bsky.social · 24/01/2025

🤩🤩🤩 Loved your presentation @dinatiniakos.bsky.social ! Great overview of where liver biopsy and pathology fits within the new MASLD nomenclature; and what the future holds with upcoming innovations! 👏🏼

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Rui Castro @ruicastrohd.bsky.social · 24/01/2025

@rautoupe.bsky.social provides an update on endothelium-platelet interactions in SLD: 🎯 LSEC capillarisation increases with liver fibrosis in MASLD 🎯 Aspirin improves MASLD 🎯 Likely by inhibiting platelet accumulation and/or platelet EV release @easlnews.bsky.social #SLDSummit

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Reposted by Rui Castro

Ramon Bataller @rbataller.bsky.social · 24/01/2025

Happy to join Bluesky. My main priority will be to contribute building a community of patient-oriented liver lovers. I also want to post about humanism, creativity, photos…. I was playing this morning to create a logo for the liver community. Cheers to all.

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Rui Castro @ruicastrohd.bsky.social · 24/01/2025

Alcohol use disorders increase after bariatric surgery. Why? 🎯 Increased consumption, sure, but also: 🎯 Alcohol pharmacokinetics 🎯 Gut hormone secretion changes Anja Geerts @easlnews.bsky.social #SLDSummit #liversky

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Reposted by Rui Castro

Science News @scinews.bsky.social · 01/12/2024

🎯Lancet Review Series 2024 @thelancet.bsky.social Natural history and progression of metabolic dysfunction-associated steatotic liver disease Image: MASLD progression Read more www.thelancet.com/journals/lan...

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Rui Castro @ruicastrohd.bsky.social · 24/01/2025

The first Young Investigator selected talk @ the #SLDSummit is pure basic science 😍 Erika Paolini used spatial transcriptomics to map the metabolic zonation of hepatocytes in MASLD, showing that PNPLA3 affects zonation by impairing periportal function 🧫🔬⚗️🧬🧪 @easlnews.bsky.social #liversky

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Rui Castro @ruicastrohd.bsky.social · 24/01/2025

There is still a lot of debate on the fatty liver disease / SLD nomenclature change, almost 2 years after endorsement by the leading Hepatology societies. Philip Newsome reflects on the importance to keep discussing the reasoning behind this change @easlnews.bsky.social #SLDSummit #liversky

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Rui Castro @ruicastrohd.bsky.social · 24/01/2025

@easlnews.bsky.social #SLDSummit kick-off! 🏃🏻‍♂️‍➡️⚽️ Introductory session & welcoming by the organisers Helena Cortez-Pinto, Christophe Moreno, Bart Staels & Gema Martinez

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Reposted by Rui Castro

Patty Bloom @bloompringle.bsky.social · 07/12/2024

FIRST BlueSky post Thrilled to be back at AASLD/EASL masterclass In just an hour our incredible team combined their different skills/interests into one beautiful team science proposal GO TEAMMAIT study 🥇 #LiverSky

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Rui Castro @ruicastrohd.bsky.social · 08/12/2024

EASL|AASLD Masterclass in Savannah, Georgia! Had so much fun talking about science communication and social media together with Patricia Bloom! #LiverSky

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