Researchers at the Biozentrum have developed a gene therapy that could potentially treat a rare and currently fatal muscle disease in children. The study shows in animal models that a single treatment...

The extracellular matrix protein laminin-α2 provides muscle fibers with essential structural support. Here, the authors show that muscle stem cells also secrete laminin-α2 to support their own prolife...

The protein Myc has long been thought to support skeletal muscle growth. Prof. Markus Rüegg's team at the Biozentrum provides compelling evidence that Myc in muscle fibers is dispensable for muscle gr...

Although AAVs are the leading platform for gene delivery to skeletal muscle, the extent to which they transduce muscle-residing mononuclear cells remains unclear. Here, McGowan and colleagues address ...

Here they use single nuclei RNA-seq to identify transcripts in skeletal muscle that maintain the neuromuscular junction, both under normal and denervated conditions, which allows them to characterize ...