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rob.mechanochemistry.org

@rob.mechanochemistry.org
49 followers 9 following 8 posts
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rob.mechanochemistry.org @rob.mechanochemistry.org · 11/07/2026
In www.biorxiv.org/content/10.6... Yean Ming Chew & I show that mutating the interPF interface in human MTs can allow them to assemble in GDP. We propose that tubulin molecules are captured indiscriminately at MT tips but then retained only if they can bind stably to a lateral nearest-neighbour.
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rob.mechanochemistry.org @rob.mechanochemistry.org · 04/12/2025
Have to feel for the grey eduWOSM. It's just so .. grey ..
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rob.mechanochemistry.org @rob.mechanochemistry.org · 22/06/2025
Nick showing Ron Vale the eduWOSM.
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rob.mechanochemistry.org @rob.mechanochemistry.org · 02/05/2025
In BIORXIV/2025/651652, we use ATPγS to reveal a previously-occult kinesin state. In the Await-Isomerisation (AI) state, ATP is bound but NL docking and hydrolysis are inhibited. ATPγS overstabilises the AI state, producing a characteristic signature of load-independent 8 nm tethered backslips:
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rob.mechanochemistry.org @rob.mechanochemistry.org · 05/04/2025
Nick has been in Rennes, helping Romain Gibeaux install a WOSM-TIRF. Big happiness!
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rob.mechanochemistry.org @rob.mechanochemistry.org · 12/02/2025
Yean Ming Chew and I wrote doi.org/10.1042/BST2... about MT lattice switching. We discuss evidence that protofilament-level structural switching is ancient and fundamental and conserved; and that tubulation creates new allosteric interfaces that operate on essentially the same structural switch.
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