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Riz Haq

@rhaq1.bsky.social

Melanoma physician-scientist @DanaFarber Asst Prof @harvardmed. Graduate @OslerResidency. @UofTMDprogram. views are my own. haqlab.dana-farber.org

Posts Replies Media

Riz Haq @rhaq1.bsky.social · 10/05/2025

We’re hiring post-docs! Join our lab on projects involving immunotherapy and therapy resistance and metastasis in cutaneous and uveal melanoma. Please DM if interested!

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Riz Haq @rhaq1.bsky.social · 10/02/2025

4/and a reduced capacity to activate cytotoxic T cells.

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Riz Haq @rhaq1.bsky.social · 10/02/2025

3/Strikingly, we found resistance-associated mutations in SEC24C and SEC24D in 3 patients. Melanoma cells engineered to express the SEC24C mutations observed in patients exhibit diminished STING signaling, including decreased Type I interferon production, antigen presentation

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Riz Haq @rhaq1.bsky.social · 10/02/2025

2/Over several years, we collected matched pre-treatment and post-resistance tumor biopsies in patients with metastatic melanoma who exhibited heterogeneous ICI responses to nominate additional mediators of acquired resistance.

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Riz Haq @rhaq1.bsky.social · 10/02/2025

1/Although some patients with metastatic melanoma experience durable responses to immune checkpoint inhibitors, most exhibit intrinsic or acquired resistance to these therapies.

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Riz Haq @rhaq1.bsky.social · 10/02/2025

Our paper on a new mechanism of resistance to immunotherapy in melanoma is now in print @Cancer_Cell with the @vanallenlab.bsky.social t.co/TCC4brc6yb

t.co

https://www.cell.com/cancer-cell/fulltext/S1535-6108(25)00027-3

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