iiinova — where your digital self keeps evolving

Reposted by Richard Unwin

Richard Unwin @rdunwin.bsky.social · 05/10/2026

NEW PAPER: Had a play comparing run length (and software) for DIA proteomics IN PLASMA (cos its not a cell lysate). Tl;dr. If you're benchmarking workflows for differential abundance, checking how many true and false hits you get is a better readout than %CV. pubs.acs.org/jprobs/artic...

pubs.acs.org

Benchmarking ZenoSWATH-DIA and Rapid-Gradient Workflows for Plasma Proteomics

Abstract. Proteomics is the large-scale study of proteins. Mass spectrometry (MS) is one of the most informative techniques for analyzing proteins. Proteom

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Richard Unwin @rdunwin.bsky.social · 7h

Raw numbers IS a rubbish metric. You can 'create' a company in an hour online. Metrics differ by discipline (an AI company will hire staff more quickly than e.g. a therapeutics company which, in turn, might need more early capital), but total jobs created and total investment are better...

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Richard Unwin @rdunwin.bsky.social · 14h

This 1000x times over. The work that food banks and volunteers do is amazing, but that it is necessary - indeed 'normal' - should be a source of national shame. Its surely just the most basic of failures to not provide people with enough money to feed and clothe themselves.

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Richard Unwin @rdunwin.bsky.social · 06/10/2026

He's just...inevitable. Hope Tuchel let's him stay on for the 90 see if he can get his 3rd. I've lost count of how often he scores 2 then gets subbed off 🤣🤦‍♂️

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Richard Unwin @rdunwin.bsky.social · 05/10/2026

pubs.acs.org

Benchmarking ZenoSWATH-DIA and Rapid-Gradient Workflows for Plasma Proteomics

Abstract. Proteomics is the large-scale study of proteins. Mass spectrometry (MS) is one of the most informative techniques for analyzing proteins. Proteom

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Richard Unwin @rdunwin.bsky.social · 02/10/2026

The squad brings back some memories. Leigh Bromby and Derek Geary? 🤣 #wawaw

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Richard Unwin @rdunwin.bsky.social · 02/10/2026

Similar discussion with my first years. Basic point was that they are paying a lot of money to come to Uni and learn stuff. They can use AI, get a decent grade and learn less. Or do it 'the hard way', get a decent grade and learn more. Their choice. I hope more opt for the latter.

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Richard Unwin @rdunwin.bsky.social · 30/09/2026

Nope. Best guess is that's just when they've got evidence for (the Der Speigel publication of the leaked documents on which this is all based was Nov 2018?) but I don't see any reason why they stopped then unless they knew it was wrong and quit (which is at odds with all their public denials)

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Richard Unwin @rdunwin.bsky.social · 29/09/2026

The statement is seriously damning. PL might chose to not strip them of titles cos that invites chaos. But given how disrespectfully they seem to have behaved - and the scale - I think they'll throw the book at the club. I wouldn't be shocked if they end up being expelled from the League.

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Richard Unwin @rdunwin.bsky.social · 29/09/2026

Well, City are fucked. #swfc got a 12 point deduction for overvaluing the ground to get round spending rules in 2020. Can only assume that doing the same thing, on a far bigger scale, over 8 seasons, and blocking the investigation, will see City down to AT least League 1?

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Richard Unwin @rdunwin.bsky.social · 26/09/2026

Already happening. There's definately a trend at Unis back towards more in-person handwritten exams with some coursework elements removed, or at least counting for less.

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Richard Unwin @rdunwin.bsky.social · 26/09/2026

It depends how you define 'proteomics people'. I've interviewed lots of folk who say they've got experience with proteomics, when in reality they lysed some cells, sent that to a core, recieved back a big spreadsheet and ran some basic stats... 🤷‍♂️

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Richard Unwin @rdunwin.bsky.social · 25/09/2026

I know I'm not quite in his demographic, but #niallhoran puts on a helluva show 😁😁 #CoopLive

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Richard Unwin @rdunwin.bsky.social · 25/09/2026

Another outstanding thread... 👏👏

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Reposted by Richard Unwin

Retraction Watch @retractionwatch.com · 24/09/2026

"If medical schools and universities don't want the literature to be overwhelmed with garbage," Oransky said, "then they should probably stop giving every applicant ... an incentive to publish a lot of crap."

medpagetoday.com

Is AI Flooding Medical Journals With 'Meaningless' Research?

'It's not fraudulent, and it's not really slop,' one expert says

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Richard Unwin @rdunwin.bsky.social · 23/09/2026

'Reform UK isn't racist even though it's member are' has strong 'Britain wasn't involved in the slave trade even though British people were' vibes.... Both stances are, of course, equally idiotic.

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Richard Unwin @rdunwin.bsky.social · 21/09/2026

That's all true of course, but she THEIR fucking idiot and so somehow they still see the need to platform her unhinged ramblings

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Richard Unwin @rdunwin.bsky.social · 20/09/2026

Yup. I've got a PostDoc trying to secure a Fellowship at the moment. Loads of papers, prizes, sits on external ECR committees, good scientist, good citizen, just can't get a break. I think she in her 6th funder now? It's brutal and we will lose good people as a result.

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Richard Unwin @rdunwin.bsky.social · 20/09/2026

It's nuts. The whole system is nuts. Application numbers are through the roof - whether due to AI or simply lower success rates driving more people to submit more to increase their odds - and funding is at best static with more and more being ringfenced. It's unsustainable.

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Richard Unwin @rdunwin.bsky.social · 12/09/2026

Good summary. 1st half of the summer was a circus. 2nd half a bit of a clown show by a poor Pakistan side. Ultimately everything else was the story apart from the cricket... Still hate the scheduling with early Tests and then a massive gap. It just breaks up the momentum of the summer.

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Reposted by Richard Unwin

Russ Jones @russincheshire.bsky.social · 09/09/2026

I did a thing about legitimate concerns, and - you'll thank me later - defined the collective noun for patriots. No paywall. russincheshire.substack.com/p/legitimate...

russincheshire.substack.com

Legitimate Concerns

How politicians turned migration into a permanent panic — and why the facts tell a different story

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Richard Unwin @rdunwin.bsky.social · 10/09/2026

Science and vaccines for the win!

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Reposted by Richard Unwin

The University of Manchester @manchester.ac.uk · 07/09/2026

What if your next big idea starts here? www.manchester.ac.uk/collaborate/... Join ambitious thinkers, changemakers and innovators from across Manchester and beyond. Build new connections, exchange ideas and explore opportunities for collaboration.

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Richard Unwin @rdunwin.bsky.social · 05/09/2026

Been reading the early copy of #TheWolfThatChewsRocks by @russincheshire.bsky.social. And it's amazing. Equal parts very funny, hugely tender (despite Baxters slightly eccentric nature - who's dog isnt), and learnt a lot. It's out for real on the 14th. Highly recommend! 😁🐾🐾

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Richard Unwin @rdunwin.bsky.social · 05/09/2026

Why is train WiFi so awful? Fourth @transportforwales.bsky.social train of the week. Fourth with little (in this case no) service. 😤

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Richard Unwin @rdunwin.bsky.social · 03/09/2026

Polymorph, or Back to Reality? lol

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Richard Unwin @rdunwin.bsky.social · 03/09/2026

This is the most accurate thing that's ever been posted on the Internet ever. Make sure to watch to the end 🤣🤣🤣

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Richard Unwin @rdunwin.bsky.social · 31/08/2026

May look for another centre half as well cos with Sil out we look thin, maybe?

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Richard Unwin @rdunwin.bsky.social · 29/08/2026

So nice to see someone run at and beat their full back so often. He looked hungry and was different class. Liked Mitchell as well. Probably less flashy but a LOT of good stuff went through him 2day 😁

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Richard Unwin @rdunwin.bsky.social · 29/08/2026

I literally cannot remember the last time I had so much fun at Hillborough. No fluke. We looked really good and should have had more! Bromley were poor - they'll probably not play that badly again all season, but we looked organised, composed, clinical. Good signs. #swfc

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Richard Unwin @rdunwin.bsky.social · 28/08/2026

Oh he's definately the greatest something, alright... 🤦‍♂️ 🍆

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Reposted by Richard Unwin

Reese Richardson @reeserichardson.bsky.social · 25/08/2026

A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵

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Richard Unwin @rdunwin.bsky.social · 21/08/2026

I often adapt a quote from Richie Benaud, former Australian cricket captain. He was talking about captaincy, but I adapt it to 'Success is 90% luck and 10% skill. But don't try it without the 10%.'

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Richard Unwin @rdunwin.bsky.social · 21/08/2026

Agree. Always the case that we needed a good start to the season, yet with lots of new faces - some of whom will work out and some won't - that's tricky. We've competed in both games. Could have had something last night with better finishing against a team in the POs last year. Its not the worst.

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Richard Unwin @rdunwin.bsky.social · 18/08/2026

And not for the first time... 🤦‍♂️🤦‍♂️

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Richard Unwin @rdunwin.bsky.social · 17/08/2026

I'm fairly sure that if you'd asked 2-3 weeks ago whether the academic quality of a Professor of Sociology, even at Cambridge, was of substantial public interest the answer would have been a resounding 'What? Who?'. The massively overblown media coverage only came from one place...

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Richard Unwin @rdunwin.bsky.social · 08/08/2026

Thought we did OK. Looked fairly well organised given the number of new players. Gray, Swinkels in particular I thought looked decent. We didn't fall too deep or look under threat after we'd scored (10 men notwithstanding). No panic and saw out the win. Good signs. Acid test is next Sat lol

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Richard Unwin @rdunwin.bsky.social · 08/08/2026

There's a great thread on this from @monkemma.bsky.social who's well worth a follow for debunking this kind of crap. Drives me insane. #WereAllPeopleArentWe

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Richard Unwin @rdunwin.bsky.social · 06/08/2026

Find stuff that works for you and stick to it unless there's a VERY good reason to change. Experience with a protocol matters. Noone can do everything, and you'll do nothing of consequence if you're constantly tweaking methods. Experiments don't have to be flashy. They have to be informative.

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Richard Unwin @rdunwin.bsky.social · 05/08/2026

It's the Carabao Cup. Timing makes it a glorified friendly for me. I don't care about the result. Would just like a decent performance and some positives to take into the actual first game of the season. #swfc

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Reposted by Richard Unwin

Gavin Buckingham @handle.invalid · 05/08/2026

New Yorker cartoon feels about right

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Richard Unwin @rdunwin.bsky.social · 04/08/2026

Someone get flip chart paper and post-its, quick!

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Richard Unwin @rdunwin.bsky.social · 04/08/2026

100%. I'm not sure folk realise just how bad it got last year. We've got lads who played 20 games for us last year who ordinarily would have been out on loan at NL North sides. Our 1st XI on Sat could have 9 or 10 new faces. Its gonna take time...

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