This systematic review and meta-analysis assesses the effects of intensive blood pressure lowering on cardiovascular and kidney outcomes overall and for effect modification by chronic kidney disease s...

This cohort study of 1.4 million females with more than 2 decades of follow-up investigates whether hypertensive disorders of pregnancy are associated with incident dementia risk.

PURPOSEWe tested the hypothesis that adding metastasis-directed therapy (MDT) to standard-of-care (SOC) systemic therapy improves progression-free survival (PFS) among patients with oligometastatic di...

Background and Aims:New obesity definitions beyond body mass index (BMI) have recently been proposed. This study aimed to assess the proportion of...

Curated by <b>Smartbrief</b>. Adults with type 2 diabetes who sleep seven or more hours a night may face a higher risk of developing diabetic nephropathy, according to a study in the <a href="https://...

Curated by <b>Smartbrief</b>. Sugar-rich foods, such as processed sweets and sweetened beverages, significantly amplify the disruption of the gut microbiome caused by antibiotics, according to a study...

Curated by <b>Smartbrief</b>. A study in the journal <a href="https://onlinelibrary.wiley.com/doi/full/10.1002/oby.70257" target="_blank" rel="noopener">Obesity</a> found that people with higher weigh...

PurposeTo evaluate the real-world comparative effectiveness of androgen receptor pathway inhibitors (ARPIs)—abiraterone, apalutamide, enzalutamide—and docetaxel, plus androgen-deprivation therapy (ADT...

Among men aged 50 years or older with diabetes and erectile dysfunction, the use of erectile dysfunction drugs was associated with a lower rate of developing proliferative diabetic retinopathy.

This cohort study examines the association of antenatal metformin exposure with child development at school entry.

Curated by <b>Smartbrief</b>. Engaging in more moderate to vigorous physical activity significantly reduces the risk of type 2 diabetes, especially among younger adults, according to research presente...

This individual participant data meta-analysis seeks to establish robust data-driven Centiloid positivity cutoffs using Centiloid values collected from multiple existing datasets with retrospective, i...

This randomized clinical trial aims to determine whether autonomous oxygen titration increases the proportion of time spent in a targeted normoxemia range compared with usual care in acutely ill adult...

This randomized clinical trial examines the effectiveness of 4 strategies for promoting smoking cessation among medically underserved persons referred for lung cancer screening.

This cohort study examines the clinical, histologic, and prognostic features of metabolic dysfunction–associated steatotic liver disease and noninvasive tests for advanced fibrosis in lean individuals...

This study estimates the residual lifetime risk of ovarian cancer among BRCA carriers.

This diagnostic/prognostic study develops and evaluates a smartphone-based 3-dimensional facial reconstruction system for automated quantitative assessment of blepharoptosis.

This diagnostic/prognostic study develops and evaluates a smartphone-based 3-dimensional facial reconstruction system for automated quantitative assessment of blepharoptosis.

This case-control study evaluates how functional performance trajectories change in the years preceding a cardiovascular disease event.

AbstractAims. To investigate the prognostic role of physical performance as a marker of vulnerability in older patients after myocardial infarction and its

Curated by <b>Smartbrief</b>. Ultrasound is effective at detecting soft tissue issues but not bone infections in patients with diabetic foot ulcers, researchers reported in the journal <a href="https:...

BACKGROUND: The diagnostic value of coronary computed tomography angiography–derived fractional flow reserve (FFR-CT) in stable coronary artery disease is well established. The prognostic value of pre...

A simple survey filled by individuals may help identify those who should undergo targeted CT imaging for coronary artery calcium and highlight gaps in preventive treatment.

PURPOSEDexrazoxane has been associated with preservation of left ventricular (LV) systolic function in relatively small studies of long-term childhood cancer survivors. What remains less clear is whet...

Curated by <b>Smartbrief</b>. Electronic health records may not accurately capture the smoking histories of women who are eligible for lung cancer screening, as about 37% of eligible women were missed...

This cohort study examines cross-sectional and longitudinal associations between smartphone ownership and eating disorder symptoms among adolescents aged 12 and 14 years in the US.

Introduction:Exercise is recommended for managing pain, yet the consistency, magnitude, and certainty of effects across different pain conditions and...

This cross-sectional study assesses the prevalence and demographic and clinical profiles among adults with clinical and preclinical obesity at high-volume metabolic bariatric surgery centers in Europe...

Curated by <b>Smartbrief</b>. Research involving nearly 288,000 participants in the UK found that adherence to four or five healthy lifestyle behaviors was associated with a 29% lower risk of overall ...

This cross-sectional study uses data from tests results from adult patients in a single facility in Korea to evaluate whether fasting duration is associated with routine laboratory test results and wh...

This randomized clinical trial examines if 2 types of telehealth-delivered cognitive behavioral therapy interventions were superior to primary care referral for patients with low-risk chest pain and a...

This cohort study investigates the association of congenital TORCH (toxoplasmosis, syphilis, rubella, cytomegalovirus, or herpes simplex) infections with neurodevelopmental and psychiatric outcomes.

This cohort study evaluates the association of adjunctive suzetrigine use with postoperative opioid consumption after head and neck free flap reconstruction or transoral robotic surgery.

This cross-sectional study develops and validates a harmonized tau positron emission tomography (PET) visual reading framework across radiotracers that stages tau burden into 5 classes.

This cohort study evaluates the association between measured lipoprotein(a) level and incident venous thromboembolism.

Immune responses leading to food allergy may develop early in life, potentially before the introduction of solid foods. Exposures to food allergens in utero and through breast milk have been propos...

Curated by <b>Smartbrief</b>. A study published in <a href="https://adc.bmj.com/content/early/2026/09/11/archdischild-2025-330159" target="_blank">Archives of Disease in Childhood</a> found that child...

In this observational study, Shengzhi Sun and colleagues examine accelerometer-derived sleep patterns in 95,559 participants from the UK Biobank and find that differences in sleep stages, duration, re...

In statin-naïve individuals developing type 2 diabetes, statin therapy was associated with lower relative and absolute risks of dementia, most pronounced in those with early statin initiation. There i...

PURPOSEEarly termination of clinical trials delays scientific progress and wastes resources, yet factors associated with trial completion in genitourinary (GU) oncology remain incompletely characteriz...

PURPOSERe-excision for close margins in patients undergoing breast-conserving surgery (BCS) for ductal carcinoma in situ (DCIS) aims to reduce recurrence rates. The current recommended margin width of...

Background: Obstructive Sleep Apnea (OSA) and Attention Deficit Hyperactivity Disorder (ADHD) are two relatively common conditions in the pediatric population, ...

Background:Hemodynamic instability in pediatric trauma is traditionally defined using reference values derived from healthy children rather than...

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This cohort study assesses the clinical utility of steatotic liver disease risk scores for predicting cirrhosis and hepatocellular carcinoma in patients with noncirrhotic steatotic liver disease.

Objective Structured exercise is widely recommended in oncology care to improve quality of life and physical function, but its definitive role as a therapeutic intervention to prolong survival remains...