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Raffaele Colombo

@raffcolo.bsky.social

210 followers 146 following 10 posts

ADCs, targeted therapies, chemistry, biotech, pharma. Associate Director @ Zymeworks

Posts Replies Media

Raffaele Colombo @raffcolo.bsky.social · 24/12/2024

For a summary of how ADC payload class has evolved over time (up to August 2024), see: aacrjournals.org/cancerdiscov...

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Raffaele Colombo @raffcolo.bsky.social · 24/12/2024

Sharing for the 🦋 aficionados: A record of 77 new ADCs entered clinical development in 2024 (including those accepted but not yet started). Payload class clearly dominated by topo1i with 55 ADCs. Greater diversity observed for antibody targets, featuring novel TAAs and several bispecific ADCs.

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Raffaele Colombo @raffcolo.bsky.social · 10/12/2024

ADC (in)stabilities: - Both sacituzumab govitecan (SG) and sacituzumab tirumotecan (sac-TMT) have an unstable carbonate linker (half-life ~24 h) that releases their respective payloads over time - SG has an additional point of instability (thiol-maleimide conjugation) Get ready for #SABCS24

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Raffaele Colombo @raffcolo.bsky.social · 28/11/2024

ADC trivia: what’s the linker stability of the newly approved (by Chinese NMPA) sacituzumab tirumotecan? 1, 2, 3, 4, 5, 6, 7, or 8? For more info on ADC linker (in)stabilities: aacrjournals.org/cancerdiscov...

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Raffaele Colombo @raffcolo.bsky.social · 27/11/2024

Sacituzumab tirumotecan (aka sac-TMT aka SKB264/MK-2870) approved in China for patients with advanced or metastatic triple negative breast cancer (TNBC) who have received at least 2 prior therapies. This brings the total number of approved ADCs to 13 worldwide (of which 11 by US FDA)!

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Raffaele Colombo @raffcolo.bsky.social · 21/11/2024

Ziihera approved!! 🎉🎉 www.prnewswire.com/news-release...

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Raffaele Colombo @raffcolo.bsky.social · 19/11/2024

Upcoming early-phase ADC data at #ASH24 (including two interesting preclinical ADCs) 66th ASH Annual Meeting (December 7-10, 2024), full program: ash.confex.com/ash/2024/web... Note: late-breaking abstracts available online on November 25! #ADC #ADCs

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