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Human Protein Atlas @proteinatlas.bsky.social · 30/09/2026

Breast cancer is the most common cancer among women worldwide with more than 2 million new cases diagnosed each year. The cancer develops in the mammary gland with invasive ductal carcinoma (IDC) being the most common type accounting for 80% of the cases. www.proteinatlas.org/news/2026-09...

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Human Protein Atlas @proteinatlas.bsky.social · 24/09/2026

Changes in metabolic pathways are frequently seen in cancer cells, and mutations in certain metabolic genes may even play a direct role in cancer development and progression. One gene for which this is true is the multi-localizing gene FH. www.proteinatlas.org/news/2026-09...

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Human Protein Atlas @proteinatlas.bsky.social · 17/09/2026

The protein FATE1 is abnormally expressed in many cancer types and using mIHC/IF it is shown to localize (green) to the cytoplasm (red) and nucleus (magenta) of Sertoli cells that support the developing sperm cells within the seminiferous ducts of testis. www.proteinatlas.org/news/2026-09...

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Human Protein Atlas @proteinatlas.bsky.social · 10/09/2026

The expression of PDX1, the transcription factor regulating the embryonic development of the pancreas and expression of insulin in beta cells in the islets of Langerhans, is shown to localize (green) to the nucleus of beta cells (magenta) using mIHC/IF. www.proteinatlas.org/news/2026-09...

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Human Protein Atlas @proteinatlas.bsky.social · 04/09/2026

Current therapies inadequately target T-cell pathways in autoimmune and inflammatory diseases limiting durable disease control. In a recent publication a novel, targetable transcriptional-metabolic axis that sustains inflammatory T-cell responses is identified. www.proteinatlas.org/news/2026-09...

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Human Protein Atlas @proteinatlas.bsky.social · 27/08/2026

A Protein Science article presents the HPA Multiplex tissue resource, with 1,106 proteins analyzed across eight antibody panels. Mapping proteins to cell types, cell states, and tissue structures give deeper insights in protein expression in human tissues. www.proteinatlas.org/news/2026-08...

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Human Protein Atlas @proteinatlas.bsky.social · 20/08/2026

A protein in the wrong place can be catastrophic ALS is associated with high morbidity and early mortality. Now it has turned out that redistribution of the protein TARDBP from the nucleus to the cytoplasm in multiple brain cell types is part of the process. www.proteinatlas.org/news/2026-08...

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Human Protein Atlas @proteinatlas.bsky.social · 13/08/2026

A recent study investigated early changes in ovarian cancer. In this interview Fabian Coscia and Mihnea-Paul Dragomir discuss how the team moved from spatial proteomics discovery to tissue-based validation using an antibody against DHCR7. www.proteinatlas.org/news/2026-08...

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Human Protein Atlas @proteinatlas.bsky.social · 05/08/2026

A study in PNAS describes how hypoxia and elimination of peroxisomes drives HCC dedifferentiation. RNF126 is identified as a hypoxia-inducible switch that determines peroxisomal fate and links the hypoxic microenvironment to loss of hepatocyte differentiation. www.proteinatlas.org/news/2026-08...

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Human Protein Atlas @proteinatlas.bsky.social · 31/07/2026

Saliva is a combination of enzyme-rich secretions from serous acini and mucin-rich secretions from mucus acini. Using mIHC/IF the regulator of acinar cell functions, BHLHA15 (green) is shown in the nucleus of serous acini (cyan) within the salivary gland. www.proteinatlas.org/news/2026-07...

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Human Protein Atlas @proteinatlas.bsky.social · 22/07/2026

Mitochondria go where they are needed Mitochondria do a lot more than ATP production. The positioning of mitochondria within cells is regulated and dynamic and their direct interactions with other organelles can regulate many cellular processes. Read more www.proteinatlas.org/news/2026-07...

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Human Protein Atlas @proteinatlas.bsky.social · 08/07/2026

Transcription factor FOXJ1 (magenta) and chromatin regulator HMGN3 (green) display different nuclear staining in the fallopian tube. FOXJ1 stains a subset of the cells in the fallopian tube epithelium while HMGN3 shows a more general staining pattern. www.proteinatlas.org/news/2026-07...

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Human Protein Atlas @proteinatlas.bsky.social · 02/07/2026

A study in Nature suggests ALDH18A1 and ferroptosis as a therapeutic target for cancer treatment. Inhibition of ALDH18A1 suppressed livercarcinogenesis through depletion of spermine (essential for cellular homeostasis) and activation of ferroptosis in HCC. www.proteinatlas.org/news/2026-07...

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Human Protein Atlas @proteinatlas.bsky.social · 25/06/2026

In this episode of Proteins Unfolded Evelina Sjöstedt, head of HPA Single cell analysis talks about the transcriptome in the context of the genome and proteome. She discusses her current research at The Human Protein Atlas and single cell transcriptomics. www.proteinatlas.org/news/2026-06...

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Human Protein Atlas @proteinatlas.bsky.social · 18/06/2026

In the Episode 82 of of the Proteomics show podcast series "Alt Proteomics" HPA researcher Dr Cecilia Lindskog talks about the importance of proteomics data integration together with the hosts Benjamin Neely and Ben Orsburn. www.proteinatlas.org/news/2026-06...

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Human Protein Atlas @proteinatlas.bsky.social · 10/06/2026

Glycolysis-associated enzyme PKLR highlighted in cytoplasm of proximal tubular cells (green) in the kidney using multiplex immunohistochemistry. Other highlighted kidney structures are Distal tubules (red), podocytes (yellow) and endothelial cells (magenta). www.proteinatlas.org/news/2026-06...

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Human Protein Atlas @proteinatlas.bsky.social · 28/05/2026

In version 25.1 of the Human Protein Atlas, a dataset based on Deep Visual Proteomics has been integrated in the Single Cell resource to provide mass-spectrometry based proteomics at an unprecedented resolution across cell types and tissues. www.proteinatlas.org/news/2026-05...

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Human Protein Atlas @proteinatlas.bsky.social · 24/05/2026

A study by HPA researchers in Nature Communications presents a high-resolution spatial map of proteins associated with motile cilia in the human fallopian tube, providing new insights into reproductive biology, infertility and cilia-related disease. www.proteinatlas.org/news/2026-05...

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Human Protein Atlas @proteinatlas.bsky.social · 13/05/2026

The Human Protein Atlas welcomes GeneTex’s recent announcement formalizing a collaborative relationship with the Human Protein Atlas. Collaborations with Atlas Antibodies, NCI-CPTC, Thermo Fisher Scientific, and Absea Biotech are also acknowledged. www.proteinatlas.org/news/2026-05...

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Human Protein Atlas @proteinatlas.bsky.social · 06/05/2026

The differences in blood protein levels during childhood and early adulthood were recently explored in an article published in Nature Communications, which highlighted the importance of accounting for age and sex when analysing protein levels in children. www.proteinatlas.org/news/2026-05...

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Human Protein Atlas @proteinatlas.bsky.social · 29/04/2026

SON and SRRM2 are essential for forming nuclear speckles and in a study in Cell it was shown that their simultaneous depletion resulted in complete dissolution of speckles, disturbing 3D-genome organization and H3 isochore gene expression. www.proteinatlas.org/news/2026-04...

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Human Protein Atlas @proteinatlas.bsky.social · 23/04/2026

In a review article published in Pharmacological reviews the current knowledge regarding structure, function, opportunities for therapeutic targeting and distribution in tissues and cells of human and mammalian aGPCRs is summarised. www.proteinatlas.org/news/2026-04...

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Human Protein Atlas @proteinatlas.bsky.social · 15/04/2026

A mIHC/IF panel is used to identify proteins expressed at specific stages of spermatogenesis. Here BEND2 is shown in the nucleus of cell state 2 spermatocytes (green) together with state 3 spermatocytes (magenta) and early (white) and late (red) spermatids. www.proteinatlas.org/news/2026-04...

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Human Protein Atlas @proteinatlas.bsky.social · 08/04/2026

In the episode 102 of the Proteomics show podcast series, "All the parts", neuroscientist at Karolinska Institute and HPA researcher Jan Mulder talks about different aspects of the brain and brain research together with the hosts Benjamin Neely and Ben Orsburn. www.proteinatlas.org/news/2026-04...

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Human Protein Atlas @proteinatlas.bsky.social · 02/04/2026

Easter celebration is very tightly linked to eggs and therefore we will take this opportunity to have a closer look at the zona pellucida proteins, some of the most important genes in the human oocyte. www.proteinatlas.org/news/2026-04...

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Human Protein Atlas @proteinatlas.bsky.social · 26/03/2026

Using mIHC/IF the adaptor protein SHC2 involved in cell signaling is shown in green in the cytoplasm of glucagon-producing alpha cells within the islets of Langerhans in pancreas . Other visualized cell types are beta cells (magenta) and delta cells (yellow). www.proteinatlas.org/news/2026-03...

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Human Protein Atlas @proteinatlas.bsky.social · 19/03/2026

At a recent high-level international meeting in Mexico City, 600 international delegated discussed trends in education, health and research. Mathias Uhlén shared a practical perspective on what universities must do as innovation cycles accelerate. www.proteinatlas.org/news/2026-03...

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Human Protein Atlas @proteinatlas.bsky.social · 12/03/2026

In a study in J.Proteome Res >180 proteins have been spatially mapped to specific subcellular compartments in cells with motile cilia using multiplex IHC. The high-resolution data aids in further functional mapping of proteins with limited evidence. www.proteinatlas.org/news/2026-03...

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Human Protein Atlas @proteinatlas.bsky.social · 05/03/2026

A study in Science demonstrate that STING acts as a molecular barrier to bird flu and that a single substitution in the viral M1 protein leads to human IAVs evading activation of human STING, demonstrating the significance of this antiviral barrier for IAVs. www.proteinatlas.org/news/2026-03...

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Human Protein Atlas @proteinatlas.bsky.social · 26/02/2026

February has been declared the gallbladder and bile duct cancer awareness month, and features the international World Cancer Day. This year's theme was "United by Unique" to raise awareness of the disease and request a cancer care more focusing on individuals. www.proteinatlas.org/news/2026-02...

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Human Protein Atlas @proteinatlas.bsky.social · 20/02/2026

In a report published in the Journal of Proteome Research last years advances and efforts within the HUPO coordinated Human Proteome Project (HPP) to define the human proteome and make proteomics an integral part of functional multiomics are presented. www.proteinatlas.org/news/2026-02...

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Human Protein Atlas @proteinatlas.bsky.social · 12/02/2026

The spatial expression pattern of TMEM213 in ductal structures of the salivary gland, based on mIHC/IF, show localization (green) to the apical part of the membrane of large ducts (red) but not to small ducts (magenta) or serous acini (cyan). www.proteinatlas.org/news/2026-02...

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Human Protein Atlas @proteinatlas.bsky.social · 04/02/2026

The HPA primary cilia research by Hansen published in Cell has been recognized as setting a new standard for understanding ciliary function and its role in health and disease in a research highlight published in Nature Signal Transduction and Targeted Therapy. www.proteinatlas.org/news/2026-02...

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Human Protein Atlas @proteinatlas.bsky.social · 29/01/2026

Detection of cancer is challenging, especially since many common diffuse symptoms overlap with non-malignant conditions. In an article in Nat. Commun. plasma protein signatures was used to identify cancer among patients with non-specific symptoms. www.proteinatlas.org/news/2026-01...

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Human Protein Atlas @proteinatlas.bsky.social · 22/01/2026

Lysosomes play a central role in the controlled degradation crucial for cellular function and homeostasis. But what if the lysosomes themselves become damaged or dysfunctional? Recently a set of key players in the process called lysophagy was identified. www.proteinatlas.org/news/2026-01...

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Human Protein Atlas @proteinatlas.bsky.social · 14/01/2026

Ciliated cells are found in the endocervical epithelium in the inner canal of the cervix. Here the CAPSL gene is shown to be localized (green) to all of the annotated subcellular structures of the cervix ciliated cells except for the cilia basal body. www.proteinatlas.org/news/2026-01...

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Human Protein Atlas @proteinatlas.bsky.social · 01/01/2026

Insulin (green) is explored in endocrine pancreas using mIHC/IF and five peptide hormone markers specifically secreted by specialized endocrine cell types, including alpha cells (cyan) and delta cells (yellow) within the islets of Langerhans. www.proteinatlas.org/news/2025-12...

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Human Protein Atlas @proteinatlas.bsky.social · 17/12/2025

In PNAS researchers have used a combinatorial protein library to select binders against the cancer receptor EGFR that allow for selection of calcium -and pH dependency, an approach that can generate fine-tuned binders and possibly enable new treatment regimes. www.proteinatlas.org/news/2025-12...

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Human Protein Atlas @proteinatlas.bsky.social · 11/12/2025

This year's Nobel Prize in Physiology and Medicine was awarded discoveries concerning peripheral immune tolerance and regulatory T cells. These immune cells play an important role in protecting us from autoimmune diseases and FOXP3 is key to their function. www.proteinatlas.org/news/2025-12...

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Human Protein Atlas @proteinatlas.bsky.social · 04/12/2025

In an article in Genetic Engineering and Biotechnology News, Gustav Ceder shares his impressions from the HUPO world congress in Toronto and the thoughts and perspectives from some of the big players in the proteomics field. www.proteinatlas.org/news/2025-12...

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Human Protein Atlas @proteinatlas.bsky.social · 26/11/2025

At the HUPO meeting in Toronto HPA members contributed more than 25 talks and posters. Loren Méar was selected as a poster competition finalist for her work "Spatial proteomics uncovers structural and molecular complexity of the human ovary in 2D and 3D." www.proteinatlas.org/news/2025-11...

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Human Protein Atlas @proteinatlas.bsky.social · 20/11/2025

Specific expression of largely uncharacterized protein TMEM52B (green) in the apical part of the cytoplasm of distal tubular cells (red) highlighted with multiplex immunohistochemistry. Other visualized kidney structures include the proximal tubules (white). www.proteinatlas.org/news/2025-11...

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Human Protein Atlas @proteinatlas.bsky.social · 11/11/2025

Version 25 of the Human Protein Atlas is launched. New additions are Olink Explore HT and SomaScan data for 32 cohorts including diseases and childhood development, more single cell data with 4 new tissues and 23000 predicted structures for protein interactions www.proteinatlas.org/news/2025-11...

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Human Protein Atlas @proteinatlas.bsky.social · 07/11/2025

It is Movember and prostate cancer is in the spotlight. Explore prognostic genes associated with survival based on transcriptomics data and find out more about prostate cancer gene expression and cell line models in the Human Protein Atlas Cancer resource. www.proteinatlas.org/news/2025-11...

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Human Protein Atlas @proteinatlas.bsky.social · 30/10/2025

An article in PNAS investigates factors influencing recombinant protein expression in CHO cells showing that transgene mRNA abundance is not important, while MW, disulfide bonds, cysteine composition and N-linked glycosylation have the strongest effect. www.proteinatlas.org/news/2025-10...

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Human Protein Atlas @proteinatlas.bsky.social · 27/10/2025

Join our project “Embedding Multimodal Data in a Vector Database to Build a Blood Atlas” remotely for the BioHackathon Europé 2025! Join the project kick-off meeting October 28 at 16:00 CET. Passcode: B8GwzS us05web.zoom.us/j/4205147624...

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Human Protein Atlas @proteinatlas.bsky.social · 22/10/2025

A study in Nat. commun. added OPTN as a player in the Golgi membrane-associated degradation GOMED. In HPA this ubiquitin-binding adaptor protein localize in a punctate pattern in the perinuclear region of the cytoplasm where also the Golgi apparatus resides. www.proteinatlas.org/news/2025-10...

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Human Protein Atlas @proteinatlas.bsky.social · 15/10/2025

CYLC1 a cytoskeletal protein associated with the 'head' structure of the sperm is visualized in late stage spermatogenesis with mIHC/IF and shown to be mainly localized (green) to the cytoplasm of cell state 2 (red) and 3 (white) of late spermatids. www.proteinatlas.org/news/2025-10...

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Human Protein Atlas @proteinatlas.bsky.social · 09/10/2025

In a study in Science, an international team of researchers have mapped how thousands of proteins in human blood shift as a result of aging and diseases. The molecular "fingerprints" from 59 diseases can enable blood tests to discern troubling signs from common. www.proteinatlas.org/news/2025-10...

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Human Protein Atlas @proteinatlas.bsky.social · 25/09/2025

In the journal Cell a deep analysis of the HPA primary cilia section is published. The primary cilia is portrayed as the most heterogeneous organelles, customized by the cell for fine-tuned environmental sensing, inspiring new views on this tiny antenna. www.proteinatlas.org/news/2025-09...

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