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Mateus Prates Rodrigues @prates-rodrigues.bsky.social · 07/02/2025

5/ Addressing these issues will push the field toward a more cohesive and impactful understanding of PD—ultimately improving future treatments.

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Mateus Prates Rodrigues @prates-rodrigues.bsky.social · 07/02/2025

4/ We need to balance model diversity with reproducibility. While new approaches are valuable, replicating and expanding on validated methods is crucial for solid scientific progress.

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Mateus Prates Rodrigues @prates-rodrigues.bsky.social · 07/02/2025

3/ A major issue: from these 135 articles, we identified 125 unique 6-OHDA models, but only 12 were replicated between articles. This extreme variability limits the reliability of findings in PD research.

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Mateus Prates Rodrigues @prates-rodrigues.bsky.social · 07/02/2025

2/ Differences in lesion protocols, timing of analyses, and outcome assessments make it difficult to compare studies

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Mateus Prates Rodrigues @prates-rodrigues.bsky.social · 07/02/2025

1/ In our review, we analyzed 135 studies using 6-OHDA models to investigate non-motor symptoms, following PRISMA guidelines for systematic reviews.

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Mateus Prates Rodrigues @prates-rodrigues.bsky.social · 07/02/2025

Excited to share our latest review in Journal of Neurochemistry! We highlight the increasing use of 6-OHDA models for studying non-motor symptoms of Parkinson’s and the need for standardization to improve reproducibility and translational value. doi.org/10.1111/jnc.... (1/N) 👇🧵

onlinelibrary.wiley.com

Challenges and Opportunities in Exploring Non‐Motor Symptoms in 6‐Hydroxydopamine Models of Parkinson's Disease: A Systematic Review

Parkinson's disease (PD), the second most common neurodegenerative disorder, involves early-emerging but poorly understood non-motor symptoms. The widely used 6-hydroxydopamine (6-OHDA) rodent model ...

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