Please check out our latest paper in Cell Reports describing the mechanism for FGF21-mediated reversal of obesity. We identified that the hindbrain (NTS/AP) and NOT the hypothalamus is the target for FGF21 to decrease body weight.
www.cell.com/cell-reports...
cell.com
Pharmacological administration of FGF21 reverses obesity through a parabrachial-projecting neuron population in the hindbrain
Lin et al. reveal that FGF21 acts on the hindbrain (nucleus of the solitary tract
[NTS] and area postrema [AP]), and not the hypothalamus, to reduce body weight. Specifically,
FGF21 signaling to the h...