iiinova — where your digital self keeps evolving

Sophie Polo Lab @polosophie.bsky.social · 02/07/2026

Congratulations to Sophie Polo on being elected to the EMBO Membership ! 🎉 We warmly thank EMBO for this recognition and for its continued support of scientific excellence and the life sciences through its outstanding community of researchers.

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Sophie Polo Lab @polosophie.bsky.social · 11/06/2026

Here is our article published in Nature Comm, on new players in chromatin dynamics after UV repair. This work highlights the histone chaperones DNAJC9 and MCM2 as central players in chromatin repair. Our proteomic dataset opens up new perspectives for dissecting epigenome maintenance mechanisms.

nature.com

Proteomic profiling of UV damage repair patches uncovers histone chaperones with central functions in chromatin repair - Nature Communications

Chromatin states need to be maintained during DNA damage repair. Here, the authors expand the histone chaperone network involved in repair-coupled chromatin restoration and highlight a mechanistic coo...

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Sophie Polo Lab @polosophie.bsky.social · 09/12/2025

Sophie Polo has been awarded an Impulscience grant from the Bettencourt Schueller Foundation to fund a research project on the establishment and maintenance of the inactive X chromosome in response to DNA breaks. This is wonderful news for the lab! We thank the Foundation for their support.

fondationbs.org

Sophie Polo

Les chromosomes, gardiens de notre identité génétique, subissent des dommages qui peuvent compromettre la santé et le destin des cellules.

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Sophie Polo Lab @polosophie.bsky.social · 08/04/2025

Sunny lab retreat in the beautiful city of Annecy! We got to know our two new post docs, Delphine and Annabelle ♥️ Working on new projects, new techniques and AI implementation (and skills for Escape games).

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Sophie Polo Lab @polosophie.bsky.social · 08/02/2025

In our new paper, we uncover a damaged chromatin marking mechanism that drives the non-random segregation of UV damage through mitosis. Chromatin alterations impinge on genome stability by controlling DNA damage segregation See Ferrand*, Dabin* et al., Nat Commun 2025.

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