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Pierre-Luc Germain

@plger.bsky.social
18 followers 13 following 10 posts

Computational biologist with a background in history&philosophy of science, working on (single-cell) RNA-seq and ATAC-seq especially in the context of stress- and activity-dependent regulation in the brain.

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Pierre-Luc Germain @plger.bsky.social · 26/08/2026
Sharing a new preprint about technical variation in (bulk/ #SingleCell ) #ATACseq and motif accessibility analyses, and methods to correct for them www.biorxiv.org/content/10.6...
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Pierre-Luc Germain @plger.bsky.social · 23/06/2026
How do >1600 transcription factors (TFs) bind across hundreds of cell types? Experimentally profiling every combination isn't practically doable. But relying on DNA motifs isn't a great alternative -- they lack both sensitivity and specificity. #Genomics #GeneRegulation 👇
Motifs are poor proxies for binding
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