iiinova — where your digital self keeps evolving

Plevka Lab @plevkalab.bsky.social · 22/03/2025

Conference season is back! 🔬🧪 We’re excited to return to Nové Hrady for the XXI Discussions in Structural Molecular Biology by @structbiocssb.bsky.social. Closing the final session, Pavel Plevka dived into the fascinating world of #enterovirus entry—a great way to wrap up the meeting!

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Plevka Lab @plevkalab.bsky.social · 09/12/2024

Hi, can our lab be added to the pack? We study interaction of phages with biofilm 🙂

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Plevka Lab @plevkalab.bsky.social · 09/12/2024

Hi, can our lab be added to the pack? 🙂

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Plevka Lab @plevkalab.bsky.social · 09/12/2024

Hi, can our lab be added to the pack? 🙂

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Plevka Lab @plevkalab.bsky.social · 09/12/2024

Hi, can our lab be added to the pack? 🙂

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Plevka Lab @plevkalab.bsky.social · 09/12/2024

Hello, can you add our lab to the pack? :)

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Plevka Lab @plevkalab.bsky.social · 09/12/2024

Can you, please, add our lab to the list? 🙂

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Plevka Lab @plevkalab.bsky.social · 09/12/2024

Can you, please, add our lab to the list?

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Plevka Lab @plevkalab.bsky.social · 09/12/2024

We would like to be added to the list 🙂

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Plevka Lab @plevkalab.bsky.social · 06/12/2024

Thank you, Lars! We’re thrilled to join this vibrant community and connect with amazing labs like yours. Looking forward to engaging discussions and collaborations in structural virology!

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Reposted by Plevka Lab

Charles University Structural Bioinformatics Group @cusbg.bsky.social · 20/11/2024

A starter pack with science institutions and research labs in Czech Republic. Let us know what is missing! go.bsky.app/Bjam2aQ

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Plevka Lab @plevkalab.bsky.social · 06/12/2024

❄️ Enjoying the first and, hopefully, not the last snow of this winter ❄️

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Plevka Lab @plevkalab.bsky.social · 06/12/2024

𝗪𝗵𝘆 𝗱𝗼𝗲𝘀 𝘁𝗵𝗶𝘀 𝗺𝗮𝘁𝘁𝗲𝗿? This study brings us closer to the fundamental understanding of the infection process. 8/9

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Plevka Lab @plevkalab.bsky.social · 06/12/2024

𝗠𝗲𝗺𝗯𝗿𝗮𝗻𝗲 𝘄𝗮𝗿𝗽𝗶𝗻𝗴 𝗮𝗻𝗱 𝗲𝗻𝗱𝗼𝘀𝗼𝗺𝗲 𝗿𝘂𝗽𝘁𝘂𝗿𝗲 Actin filaments observed at membrane protrusions, along with actin polymerisation inhibition results suggest cellular actin can drive endosome rupture. 7/9

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Plevka Lab @plevkalab.bsky.social · 06/12/2024

On the contrary, inhibition of endosome acidification didn’t stop genome-containing particles from exiting the endosomes. 6/9

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Plevka Lab @plevkalab.bsky.social · 06/12/2024

𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘂𝗹𝗮𝗿 𝗺𝗲𝗰𝗵𝗮𝗻𝗶𝘀𝗺𝘀 𝗯𝗲 𝗶𝗻𝘃𝗼𝗹𝘃𝗲𝗱? 🦠 Inhibition of the actin polymerisation led to genome release within the endosomes, hindering the virus replication. 5/9

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Plevka Lab @plevkalab.bsky.social · 06/12/2024

𝗛𝗼𝘄 𝗱𝗶𝗱 𝘁𝗵𝗲𝘆 𝗱𝗼 𝗶𝘁? Using advanced #cryoET at #CEITEC cryoEM facility to visualise cell entry of rhinovirus 2, echovirus 18, echovirus 30, and enterovirus 71 – right in action! 🔎 4/9

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Plevka Lab @plevkalab.bsky.social · 06/12/2024

𝗞𝗲𝘆 𝗙𝗶𝗻𝗱𝗶𝗻𝗴𝘀 This study reveals that enterovirus-containing #endosomes can deform and rupture, enabling the release of genome-containing particles into the cytoplasm. 3/9

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Plevka Lab @plevkalab.bsky.social · 06/12/2024

#Enteroviruses, members of the Picornaviridae family, cause illnesses ranging from the common cold to encephalitis 😷 However, the infection process was never observed 𝘪𝘯 𝘷𝘪𝘷𝘰 - until now. 2/9

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Plevka Lab @plevkalab.bsky.social · 06/12/2024

✨𝗡𝗘𝗪 𝗣𝗔𝗣𝗘𝗥 𝗔𝗟𝗘𝗥𝗧✨ We are happy to announce that the paper by Aygul Ishemgulova and members of our group, describing the novel mechanism of cell invasion by enteroviruses is now published in @commsbio.bsky.social ! 🦠 Let’s break it down! 🧵 1/9

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Plevka Lab @plevkalab.bsky.social · 06/12/2024

Hello Bluesky! We're the Plevka Lab, a structural virology research group at CEITEC. Using techniques like SPA #cryo-EM and #cryo-ET 🔬, we explore the fascinating structures of viruses to uncover their secrets. Follow us for research updates, insights, and a glimpse into the world of #virology! 🧫 🦠

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