Marinocyclins, polycationic macrocyclic depsipeptides, were discovered by genome mining from the marine coral-derived bacterium Aquimarina megaterium. The compounds have broad-spectrum activity again...

Noncanonical biochemistry of the peloruside PKS characterized in this work, comprising double bond generation by a noncanonical tridomain (blue), acetyl-CoA recycling (orange), and proofreading syste...

Reconstructing microbial genomes from 820 reef-building corals collected at 99 reefs across 32 islands throughout the Pacific Ocean highlights the importance of conserving coral reefs as vital reservo...

Vadakumchery, Meier, Forneris, et al. report a family of β6.3-helical ribosomal peptides that occurs in phylogenetically diverse and well-known bacteria. Their study provides insights into the structu...

Marine sponges host bacteria that produce diverse bioactive compounds. Here, the authors conduct a large-scale metagenomic, single-bacterial and biochemical study to reveal the untapped biosynthetic p...