iiinova — where your digital self keeps evolving

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 02/10/2026

2 weeks left to submit your work for the 2027 International Congress on Integrative Medicine & Health! Abstract, session, and wellness activity proposals are due October 16, 2026 📍 Minneapolis | April 13–15, 2027 🗓️ Pre-Congress Workshops: April 12 Submit your proposal: zurl.co/xUUzF

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 02/10/2026

☀️ Another article is now published in the Nutrients Special Issue I am serving as Guest Editor for, “Vitamin D Status and Immune Health: Determinants, Mechanisms, and Clinical Implications.” 📅 Submission deadline: March 15, 2027 🔗 Article: zurl.co/Yjjrn 🔗 Special Issue: zurl.co/wlkRX

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 01/10/2026

💧 Wellness marketing does not need to convince you that plain water is dehydrating. It only needs to suggest that water is missing something. My new piece examines electrolytes, hydration, and what the evidence actually supports 👉 zurl.co/RPok2 #Electrolytes #Hydration #Nutrition #HealthScience

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 01/10/2026

🌱 Join A Mindfulness Experience this Friday with Robin Carnes for Humming for Healing & ANS Regulation. Explore the science behind humming and experience a guided mind-body practice. 🗓️ Friday, October 2 ⏰ 2–3 PM ET 💻 Live on Zoom Register here: zurl.co/lHjli #IntegrativeMedicine #WholeHealth

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 30/09/2026

Beating Heart Moment | Week 40 Fred Johnson returns with an interactive sound health practice exploring frequency, intentionality, and the Sankofic mantra “Dahm’ Su.” Watch the full sonic exercise: zurl.co/nSOVL #MusicAsMedicine #IntegrativeMedicine #WholeHealth #SoundHealth #VagusNerve

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 29/09/2026

Brain health is an important part of overall well-being and healthy aging. 🧠 Research continues to show that factors such as physical activity, quality sleep, managing health conditions, and staying socially connected can influence cognitive health and healthy aging. Read more: zurl.co/x09wA

001

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 28/09/2026

Missed A Mindfulness Experience? The recording is now available. Explore mindfulness, resilience, art, and whole-person well-being with Chris Palmer, Mia Angarita, Becca Steynberg, and Mikhail Kogan, MD. Watch the recording: zurl.co/No3OG #IntegrativeMedicine #Mindfulness #ArtTherapy #Resilience

010

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 28/09/2026

🕐 Your body runs on more than one clock. Light sets the brain’s master clock, while food timing helps regulate clocks in organs like the liver and gut. That’s an important piece of the intermittent fasting conversation that often gets overlooked. 🎥 Watch the video and read more: zurl.co/Awsz3

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 25/09/2026

Does coffee actually dehydrate you? Caffeine can increase urine output, but that does not automatically mean dehydration. For most habitual coffee drinkers, ordinary amounts of coffee contribute to daily fluid intake. The effect can depend on dose and caffeine tolerance. Learn more: zurl.co/M2SMv

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 25/09/2026

30 grams of fiber may look the same on a label, but biologically, they aren’t necessarily equivalent. Fiber from intact plants differs from extracted fiber added to processed foods, including how it interacts with our gut microbes. Read more: zurl.co/9T1Q5

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 24/09/2026

In case you missed it, Ellen Goldsmith of Pearl Natural Health, joined us for A Mindfulness Experience to share ways to support well-being as we move into the fall season. Scroll through to learn more. 🎥 Watch the full episode on YouTube: zurl.co/utUjS

011

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 24/09/2026

Join us live this Friday for A Mindfulness Experience with Dr. Anne Berkeley! 🌿 Explore body awareness, nervous system regulation, and a short guided relaxation + body scan. 📅 Friday, 2 PM ET on Zoom 🔗 zurl.co/gDs4N Bring your health and wellness questions for the live Q&A with Mikhail Kogan, MD

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 23/09/2026

Vitamin D research continues to evolve, and evidence-based discussion can help shape future public health policies and clinical guidelines. Know someone in public health, healthcare, or guideline development? Share this presentation with them. 🔗 Watch & share: zurl.co/oja5R

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 23/09/2026

The Sun-D Trial found daily SPF50+ sunscreen resulted in a smaller vitamin D increase than discretionary use: 1.6 vs. 6.8 nmol/L. But it measured vitamin D, not skin cancer risk. More: zurl.co/zDDel PubMed: zurl.co/ROCTO DOI: zurl.co/ZWcCE

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 22/09/2026

💧 Do you actually need electrolytes? Wellness marketing has convinced a lot of people that plain water is not enough. The physiology used to support that claim is real. The universal conclusion brands want you to draw from it is not. Read the new piece 👉 zurl.co/V1e1Y

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 21/09/2026

What are peptides, and why should we care about them? In this episode of the @GWIntegrative Medicine podcast, Misha Kogan, MD, explores what peptides are, why they’re gaining attention, and what we should know about them. 🎧 Listen here: zurl.co/Mm3l1

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 20/09/2026

One year ago, The Beating Heart brought together science, spirituality, music, and ancient wisdom to explore health and healing. 🌿 The conversation helped inspire The Beating Heart Moment, AIM Health Institute’s weekly online offering. 🎥 Watch the full workshop: zurl.co/62lMJ

001

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 18/09/2026

A new study linked low- and no-calorie sweeteners to faster cognitive decline, but the headlines went beyond the data. The observational design can’t show causation, and the analysis has raised concerns about missing data and statistical inconsistencies. 🔗 zurl.co/1gu0M

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 18/09/2026

Polyphenols are not one thing. They are everywhere--any system with plants in it. -Dr. Kelly Wrighton, CSU SoCal Microbiome Symposium UC Irvine

010

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 18/09/2026

Conference 2 of 2 on my Orange County science tour: SoCal Microbiome Symposium @UCIrvine hosted by Dr. Katrine Whiteson et al. 🍊+🤓=😎

010

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 18/09/2026

Join us this Friday for A Mindfulness Experience with special guest Ellen Goldsmith of Pearl Natural Health. Ellen will share Qi Gong and breathing practices, along with insights on supporting health and vitality through Chinese medicine. 🧘 Friday, Sept. 18 🕑 2–3 PM ET 💻 Zoom 🔗 zurl.co/dyxfy

010

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 17/09/2026

Fatigue isn’t always about sleep. 🧬 A new exploratory study examined links between homocysteine, B12, folate, fatigue, and motivation in 602 healthy adults. The findings are intriguing, but they do not show that one caused the other. Kanouchi H, et al. Nutrients. 2026;18(6):941. 🔗 zurl.co/isyIC

010

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 16/09/2026

🌿 Your gut microbiome thrives on variety. Good Bacteria’s Rotating Synbiotic System uses weekly blends of prebiotics, probiotics, and postbiotics to support digestive health and microbial balance. Learn more and explore the 28-day rotating system here: zurl.co/lEOrc

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 15/09/2026

Join the @GWResiliency & Well-being Center for “Battling the Inner Critic” on Thursday, October 22, 2026, from 12–1 p.m. ET. Joia Jefferson Nuri, PCC, will share practical strategies for understanding and working with the inner critic. Learn more and register: zurl.co/S1G4R

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 14/09/2026

A recent Perspective in Science argues that the randomized trials cannot isolate an effect of “ultra-processing” independent of those characteristics. On that narrow question, the authors make a strong case. Read it my blog: zurl.co/JDK2L #UltraProcessedFoods #Nutrition #GutHealth #Microbiome

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 11/09/2026

Supporting your health as you age starts with the everyday habits you can sustain over time. Prioritizing movement, nourishing your body, getting enough sleep, staying connected, and building resilience can all contribute to healthy aging. 🔗 Learn more from @HopkinsMedicine: zurl.co/TSuqc

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 10/09/2026

A new Cochrane review on intermittent fasting just made headlines, and it's a null result: across 22 trials and nearly 2,000 adults, intermittent fasting barely outperformed regular dietary advice for weight loss. 🔗 Read the full piece on Substack: zurl.co/se395

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 09/09/2026

In this episode of A Mindfulness Experience, Ajowa Ifateyo of GW CIM shares how greater awareness can support more mindful eating and overall well-being. 🎥 Watch: zurl.co/xGqk2 🧘 Fridays | 2–3 PM EST | Free on Zoom zurl.co/QvC0W

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 09/09/2026

🧬 A new Cell study reveals another way vegetables may support cardiometabolic health. Gut bacteria can convert dietary nitrate + non-heme iron into DNICs, which improved blood pressure, vascular function, glucose control, and liver fat in mice. 📄zurl.co/UebP4 📄 zurl.co/WIQDd

211

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 08/09/2026

Join us at dose. wellness spa for Longevity Yoga—an all-levels practice designed to support strength, mobility, balance, breath, and nervous system regulation as we age. 🧘‍♀️ Thursdays | 5:00–6:00 PM 📅 9/24, 10/1, 10/15 & 10/29 🌿 All levels welcome 📍 dose. wellness spa, St. Michaels 🔗 zurl.co/6zgJc

200

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 08/09/2026

We test cholesterol. So why don’t we routinely test environmental exposures? A new JAMA Pediatrics study on prenatal pesticide exposure raises an important question about the role of environmental assessment in preventive care. Dr. Mikhail Kogan discusses the bigger picture. 🔗zurl.co/BcXyH

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 07/09/2026

Cannabis for Alzheimer’s agitation: breakthrough study—or 10 years too late? Dr. Mikhail Kogan discusses the LiBBY Trial, a randomized Phase 2 study of controlled THC/CBD in people with advanced dementia. Watch the full conversation: zurl.co/uuX2b

120

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 04/09/2026

Good Bacteria just earned the Clean Label Project Purity Award. 🎉 A meaningful recognition of the care, intentional formulation, and rigorous independent testing behind every 4-gram sachet. Proud of the standard we set. ❤️ 🔗 zurl.co/KCclQ 📸 Good Bacteria | Instagram

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 03/09/2026

A new randomized trial found daily SPF50+ sunscreen use may reduce vitamin D status. But the bigger question is how we think about sunlight, UV exposure, skin pigmentation, and vitamin D. I break down what the trial found and what it didn’t. 🔗zurl.co/X0fZu #VitaminD #Sunscreen #IntegrativeMedicine

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 02/09/2026

The trial's own authors have a measured take: keep using sunscreen, monitor your vitamin D. I think that's reasonable, and too narrow. Treating all sun exposure as dangerous, or treating it as broadly protective against cancer, both go further than the evidence supports. Read more:🔗 zurl.co/WQovP

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 01/09/2026

A network meta-analysis of 30 randomized controlled trials found yoga ranked highest among exercise interventions for improving sleep quality in adults with sleep disturbances. 🔗 Study: zurl.co/7tV4j 🔗 Longevity Yoga: zurl.co/JHLr9

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 31/08/2026

My colleague Carmen Ortega-Santos, PhD, RD, and the FITGut Lab at George Washington University are recruiting participants for several studies exploring the relationships among gut health, metabolism, nutrition, and exercise. Interested or know someone who may qualify? Learn more: zurl.co/WNiYa

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 28/08/2026

What happens to vitamin D status after you stop supplementing? A small pilot study found that 25(OH)D levels rose with supplementation but fell during 30-day breaks. Individual responses also varied substantially. Study: Kralova M, et al. In Vivo. 2025;39(1):452–458. PubMed: zurl.co/LxxFw

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 27/08/2026

Every year, there’s another molecule that’s going to change everything. This year, it’s peptides. My latest article looks at the rise of BPC-157, TB-500, and others—and why regulatory momentum is not the same as scientific proof. 🔗 zurl.co/urf0S

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 27/08/2026

Join us this Friday for A Mindfulness Experience with special guests Ajowa Ifateyo and JD Talasek 🌱 Bring your health and medicine related questions for the live Q&A with AIM Health Institute Founding Director Mikhail Kogan MD 🔗 Register: zurl.co/P2Xak

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 26/08/2026

A #Nutrition2026 study found that teens who started eating breakfast consumed more key nutrients and fewer sweets. Higher-protein breakfasts showed additional benefits. The findings are preliminary, but they add to the evidence that breakfast may support healthier eating patterns. 🔗zurl.co/vHuWz

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 25/08/2026

📸 AI can make tracking what you eat much easier. That does not necessarily mean it is tracking it accurately. I spoke with Healio about new research presented at #Nutrition2026 evaluating four AI-powered, photo-based calorie-tracking apps. 🔗 Read more: zurl.co/3S8rC

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 24/08/2026

My Letter to the Editor, published in Global Advances in Integrative Medicine and Health, argues that whole-person health, integrative medicine, lifestyle medicine, functional medicine, and federal healthcare policy are converging around that shared challenge. Read the letter: 🔗 zurl.co/QBVqK

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 21/08/2026

A small pilot trial presented at #NUTRITION2026 found modest improvements in problem-solving among older women following an 8–9 hour eating window. It’s promising, but early evidence—not a recommendation. Larger, peer-reviewed studies are needed. 🔗zurl.co/F64tk

010

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 21/08/2026

Our new study of 449 patients explores what happens when we stop studying it in isolation. Proud of this student-led project, led by Connor Tseng with a terrific student team, clinical data from Dr. Mikhail Kogan’s patient population, and me as senior author. 📰 zurl.co/TiVRe 📄 zurl.co/q80zr

010

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 20/08/2026

If the gut microbiome is as individual as a fingerprint, defining a “healthy” microbiome by who is there may miss the bigger picture. The more useful question may be: What is the microbial community doing? My reflection from Nutrition 2026: 🔗 zurl.co/a2HVo

010

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 19/08/2026

Is BPC-157 legal now? Not exactly. An FDA advisory committee vote may influence the future of compounding, but it does not mean FDA approval. Here's what actually changed—and what didn't. 🔗 zurl.co/VcI9t

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 18/08/2026

🧠 A new observational study (ADNI, 800+ older adults) found omega-3 supplement users showed faster cognitive decline than non-users on several standard assessments. 🔗 Summary: zurl.co/a4hJJ 🔗 Study: zurl.co/F8XXr

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 17/08/2026

Grateful to join the Johns Hopkins Medicine Alumni Association Alumni Council. Hopkins shaped how I approach research, education, and mentorship — it's a privilege to now give back and work alongside a group of alumni dedicated to supporting students and advancing the Hopkins mission. zurl.co/Lmsdl

000

Leigh A. Frame 🍎🥕🍋🥦🍇 @phdleigh.bsky.social · 14/08/2026

A new Science study found that protein deficiency activated gut-brain signals that shifted food preference toward protein-rich foods in animal models, offering new insight into how the body may help regulate nutrient-specific appetite. Read more: 📖zurl.co/BtggR 📄 zurl.co/QNfoB

000