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Perrier Lab

@perrier-lab.bsky.social
159 followers 79 following 9 posts

Brain research lab interested in #neurons, #astrocytes, #motor control, #memory, and #neurodevelopmental encephalopathies, #STXBP1, #GABRB3 #epilepsy #hippocampus #interneurons #cortex #serotonin #fatigue #synapse

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Perrier Lab @perrier-lab.bsky.social · 23/04/2026
Can too much inhibition cause epilepsy? Our new paper in Brain suggests that, paradoxically, the answer can be yes. Check our new paper published in Brain. @rikkesmoller.bsky.social @neuroscience-ucph.bsky.social academic.oup.com/brain/advanc...
academic.oup.com
Collapse of feed-forward inhibition underpins hyperexcitability in GABAA gain-of-function epilepsy
Paradoxically, mutations that enhance GABAA receptor function cause severe epilepsy. Using a mouse model of a human gain-of-function GABAA receptor mutatio
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Perrier Lab @perrier-lab.bsky.social · 14/03/2025
Excellent PhD Course in Advanced Neuroscience: Molecular, Cellular and #Synaptic Properties of #Brain Function #NAD bsky.app/profile/perr...
bsky.app
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Perrier Lab @perrier-lab.bsky.social · 08/01/2025
www.researchsquare.com/article/rs-5...
researchsquare.com
Astrocytes provide the temporal dynamic required for memory formation
Theta oscillations (4-12 Hz) in the hippocampus, driven by synchronous neuronal bursts, are essential for grouping and selecting neuronal ensembles during spatial navigation, memory, and learning 1,2....
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Perrier Lab @perrier-lab.bsky.social · 20/12/2024
Muscle spindle macrophages regulate motor coordination www.nature.com/articles/s41...
nature.com
Muscle spindle macrophages regulate motor coordination - Nature Reviews Immunology
Yan et al. report the identification of a population of muscle spindle macrophages, which regulate the muscle stretch reflex through glutamate production.
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Perrier Lab @perrier-lab.bsky.social · 20/12/2024
www.nature.com/articles/s41...
nature.com
An unexpected role for macrophages in motor control - Nature Reviews Neuroscience
A population of macrophages has been found in muscle spindles that release glutamate, activate primary sensory afferents that are part of the stretch reflex, and have a role in regulating locomotion.
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Reposted by Perrier Lab
Neuroscience Academy Denmark @naddenmark.bsky.social · 09/12/2024
Register for the NAD PhD Course in Advanced Neuroscience: Molecular, Cellular and Synaptic Properties of Brain Function 🔬🧠 📅 WHEN: March 10-14, March 2025 🌍 WHERE: Comwell Bygholm Park, Horsens ⏰ DEADLINE: December 31 Read more and register 👉 bit.ly/4hqmO7X
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Perrier Lab @perrier-lab.bsky.social · 04/12/2024
Over a century after Sherrington's discovery of the stretch #reflex, muscle #spindles continue to surprise us. Check out this new paper from the labs of Bellardita and Di Giovanni, revealing that #macrophages directly excite muscle spindles to enhance #locomotion. www.nature.com/articles/s41...
nature.com
Macrophages excite muscle spindles with glutamate to bolster locomotion - Nature
A population of macrophages with exclusive molecular and functional signatures in the muscle spindles express machinery for synthesizing and releasing glutamate, and a cellular component, the muscle s...
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Perrier Lab @perrier-lab.bsky.social · 30/11/2024
Synapse Biology in Health and Disease Symposium, Copenhagen, 23-25 January 2025 eventsignup.ku.dk/synapsebiolo...
eventsignup.ku.dk
Synapse Biology in Health and Disease
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Reposted by Perrier Lab
CLaE @claeneuro.bsky.social · 13/11/2024
Nature Learning-associated astrocyte ensembles regulate memory recall www.nature.com/articles/s41...
nature.com
Learning-associated astrocyte ensembles regulate memory recall - Nature
A study in mice shows that learning induces c-Fos expression in a subset of astrocytes in the hippocampus, and that ensembles of these learning-associated astrocytes are involved in the recall of memo...
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