Can too much inhibition cause epilepsy? Our new paper in Brain suggests that, paradoxically, the answer can be yes. Check our new paper published in Brain. @rikkesmoller.bsky.social @neuroscience-ucph.bsky.social
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Collapse of feed-forward inhibition underpins hyperexcitability in GABAA gain-of-function epilepsy
Paradoxically, mutations that enhance GABAA receptor function cause severe epilepsy. Using a mouse model of a human gain-of-function GABAA receptor mutatio