perlstein.bsky.social @perlstein.bsky.social · 30/04/2026Another day another impressive honors thesis defense from the Perlstein lab. Congratulations mark - you did great and UCSB is lucky to have you join their PhD program. We will miss you but can’t wait to see what you do next 000
perlstein.bsky.social @perlstein.bsky.social · 30/04/2026Congrats Marisa on your successful defense of you “honours” thesis - you are amazing and I cannot wait to see what you do next 010
perlstein.bsky.social @perlstein.bsky.social · 09/04/20264/ The surprising part: Peptides with different sequences and binding orientations can be recognized by the same site since they satisfy the same underlying energetic logic. → A single “decoder” can recognize distinct substrates via degenerate binding modes Congrats to authors and collaborators! 030
perlstein.bsky.social @perlstein.bsky.social · 09/04/20263/ What does this hierarchy look like in practice? The C-terminal “acid anchor” and a “primary pocket” drive binding while surrounding sites fine-tune affinity in a sequence-context dependent manner. → A few key interactions do the heavy lifting; the rest tune specificity. 100
perlstein.bsky.social @perlstein.bsky.social · 09/04/20262/ Our key finding: Decoding isn’t constrained by a strict consensus sequence. Instead, a hierarchy of interactions determines recognition, with specific physicochemical features dominating binding energetics. → It’s chemistry, not sequence, that underpins decoding. 100
perlstein.bsky.social @perlstein.bsky.social · 09/04/20261/ How does the cytosolic iron–sulfur cluster assembly (CIA) system identify its dozens of clients? Like any good CIA agent, it uses a secret code🕵️ … and we think we’ve found the decoder. New Perlstein Lab preprint: www.biorxiv.org/content/10.6... 163
perlstein.bsky.social @perlstein.bsky.social · 29/03/2025anyone need a really great postdoc or scientist to join their company? Jackson will take on whatever hard problem you throw at him while making the lab environment welcoming and friendly. can't say enough good things about this young scientist! 000
perlstein.bsky.social @perlstein.bsky.social · 11/03/2025Don't miss Anastasiya's talk at #ACSspring2025 yall! it is going to be FANTASTIC! So proud to be (former) PI of this Emergent Leader - watch out world! Lets go! 010
perlstein.bsky.social @perlstein.bsky.social · 08/03/2025Standupforscience DC - here for a family thing - here for science 000
perlstein.bsky.social @perlstein.bsky.social · 14/12/2024Had a little party today to welcome a new group member- not a bad Friday the 13th! 010
