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Phil Campbell

@pdcampbell.bsky.social
200 followers 120 following 8 posts

Assistant Professor | Psychiatrist-Scientist | Using zebrafish to better understand neurodevelopmental disorders | University of Pennsylvania | www.pdcampbelllab.com

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Phil Campbell @pdcampbell.bsky.social · 16/06/2026
This work has now been accepted - Congrats to all involved! doi.org/10.1242/dmm.... #Neurodevelopment #Genetics #Zebrafish
doi.org
Unique and overlapping behavioral effects of isoform-specific NRXN1 deletions
Mutations in the human neurexin 1 (NRXN1) gene are associated with neurodevelopmental disorders including autism and schizophrenia. Vertebrate NRXN1 produces three major NRXN1 isoforms, named α, β, an...
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Phil Campbell @pdcampbell.bsky.social · 23/01/2026
Together, our data suggest that different NRXN1 deletions can give rise to distinct behavioral outcomes, underscoring the importance of considering deletion type when interpreting NRXN1 variants.
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Phil Campbell @pdcampbell.bsky.social · 23/01/2026
Key findings: • NRXN1 isoform-specific deletions produce distinct behavioral phenotypes • Behavioral phenotypes emerge early in development • α-specific loss does not fully recapitulate whole-gene deletion
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Phil Campbell @pdcampbell.bsky.social · 23/01/2026
Excited to share the first preprint from our lab! Our work examines how isoform-specific NRXN1 deletions—a gene strongly associated with neurodevelopmental disorders—shape sensorimotor and social behavior in zebrafish. www.biorxiv.org/content/10.6... #Neurodevelopment #Genetics #Zebrafish
biorxiv.org
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Phil Campbell @pdcampbell.bsky.social · 06/01/2025
Please DM or email if interested! sites.google.com/view/campbel...
sites.google.com
Campbell Lab
Current treatments for neuropsychiatric disorders are largely inadequate. At the core of this issue is a lack of understanding of the biological mechanisms underlying these disorders. How do we begin ...
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Phil Campbell @pdcampbell.bsky.social · 06/01/2025
We are looking to hire at all levels - undergrads, research technicians, graduate students, postdocs. Experience with zebrafish, induced pluripotent stem cell models, molecular genetic approaches, imaging, or programming is desirable but not required.
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Phil Campbell @pdcampbell.bsky.social · 06/01/2025
We use the zebrafish system to understand how genetic variants associated with neurodevelopmental disorders such as schizophrenia and autism generate brain and behavioral phenotypes with the goal to identify novel mechanistic insights, disease biomarkers, and treatments.
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Phil Campbell @pdcampbell.bsky.social · 06/01/2025
I am excited to announce that I will be starting my own lab in the Department of Psychiatry at the University of Pennsylvania next month!
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