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Paul Knabl

@paulknabl.bsky.social
234 followers 250 following 4 posts

EvoDevo & cnidarians. Postdoc in the Sebé Pedrós lab at CRG. Previously PhD student in the Genikhovich group at Uni Vienna.

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Reposted by Paul Knabl
PLOS Biology @plosbiology.org · 22/05/2026
Bilaterian BMP signaling gradients suggest an ancestral anti-neural role. Study of #cnidarians shows that #BMP signalling promotes neurogenesis; its "anti-neural" function is a side effect of its role in the DV axis @paulknabl.bsky.social @genikhovich.bsky.social @plosbiology.org 🧪 plos.io/4dJHoiR
In the box jellyfish Tripedalia cystophora, BMP signaling is active in ganglionic neurons of the umbrella, the ring nerve and in the rhopalium. Top left: Oral view of the umbrella, black arrowheads highlight the location of the rhopalia (rh). Top right: lateral and frontal detail of the rhopalium anatomy. Bottom, from left to right: pSMAD1/5 activity in the rhopalia, lateral view of the rhopalium, view from the top highlights pSMAD1/5 activity around the stalk, detailed view of the pit eye and the area around it (pSMAD1/5 is observed in a sector of the pit eye retina, the upper lens eye and some cells between the pit eye and the stalk).
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Paul Knabl @paulknabl.bsky.social · 02/12/2025
Congrats to Nadja and the @tessmarraiblelabs.bsky.social. Check out their cool new work (featuring a small sketch I made)!
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Reposted by Paul Knabl
genikhovich.bsky.social @genikhovich.bsky.social · 13/06/2025
David’s @davidmoersdorf.bsky.social cool paper about the role of Chordin in BMP signaling in the sea anemone Nematostella is finally out www.science.org/doi/10.1126/...
science.org
Chordin-mediated BMP shuttling patterns the secondary body axis in a cnidarian
Chordin-mediated BMP shuttling is the candidate mechanism for generating bilateral symmetry in the cnidarian-bilaterian ancestor.
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Reposted by Paul Knabl
genikhovich.bsky.social @genikhovich.bsky.social · 09/06/2025
The last part of @paulknabl.bsky.social 's PhD is now available at www.biorxiv.org/content/10.1... Paul showed that BMP signaling is active in the diffuse nervous system of the sea anemone Nematostella and the box jellyfish Tripedalia. Moreover, suppression of BMP signaling in Nematostella leads...
biorxiv.org
The anti-neural role of BMP signaling is a side effect of its global function in dorsoventral patterning
In Bilateria with centralized nervous systems (e.g. in vertebrates or arthropods), the minimum of the BMP signaling activity gradient defines the position of the central nervous system. BMP-dependent ...
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Reposted by Paul Knabl
genikhovich.bsky.social @genikhovich.bsky.social · 21/02/2025
Our atlas of BMP signaling activity in adult Nematostella is finally out! Fantastic, meticulous work and beautiful illustrations by @paulknabl.bsky.social Thanks, @fwf-at.bsky.social for funding our work! bmcbiol.biomedcentral.com/articles/10....
bmcbiol.biomedcentral.com
A whole-body atlas of BMP signaling activity in an adult sea anemone - BMC Biology
Background BMP signaling is responsible for the second body axis patterning in Bilateria and in the bilaterally symmetric members of the bilaterian sister clade Cnidaria—corals and sea anemones. Howev...
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Reposted by Paul Knabl
Malte Mederacke @maltemederacke.bsky.social · 15/01/2025
Big parts of my PhD work is now out on bioRxiv!! We look at how biophysical parameters shape the fractal lung during development and disease. Go check it out: www.biorxiv.org/content/10.1...
biorxiv.org
The emergence of the fractal bronchial tree
The fractal design of the bronchial tree, as described by the Hess-Murray law, facilitates energy-efficient lung ventilation, yet its developmental origins remain unclear. Here, we quantify the rearra...
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Paul Knabl @paulknabl.bsky.social · 10/01/2025
I recently got to illustrate the graphical abstract for this beautiful work on stem cells and regeneration in the #bristleworm by @alexwstockinger @leonieadelmann @tessmarraiblelabs.bsky.social Check it out!
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