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EK MD, FCAP, FASCP, member of USCAP/ASC/PAPS @pathologist.bsky.social · 23/11/2024

Low-Grade Endometrial Stromal Sarcoma (LG-ESS), uterus: Proliferative-phase endometrial stromal-type tumor cells with “tongue/finger-like pattern” of myometrial invasion, frequent LVI - CD10, IFITM1 & ER/PR positive! #pathology #pathsky #gynpath #oncsky #sarcoma #lgess #surgicalpathology #pathart

Monotonous oval to spindle cells with minimal cytologic atypia, often demonstrating whorling around blood vessels

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EK MD, FCAP, FASCP, member of USCAP/ASC/PAPS @pathologist.bsky.social · 22/11/2024

The human epidermal growth factor receptor 2 (HER2), one of the most common biomarkers assessed by scoring of IHC-stained tissue: Overexpressed in 15-25% of breast carcinomas (likely to respond to HER2 targeted therapy) #biomarkers #oncology #Her2 #breastcancer #pathology #surgicalpathology #pathsky

Score 0, 1+, 2+, 3 by IHC of a breast carcinoma

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EK MD, FCAP, FASCP, member of USCAP/ASC/PAPS @pathologist.bsky.social · 22/11/2024

Glomus Tumor, index finger, H&Es, 10x, 40x & 100x and immunostains - Composed of 3 components: 1. Glomus cells 2. Vasculature 3. Smooth muscle cells Vimentin, SMA, h-caldesmon & CD34 positive and CKs & S100 negative! #pathology #pathsky #softtissuepathology #glomustumor #surgicalpathology #pathart

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EK MD, FCAP, FASCP, member of USCAP/ASC/PAPS @pathologist.bsky.social · 21/11/2024

Salivary Duct Carcinoma (SDC), parotid, H&Es,20 & 40x, AR and PAP smears: Aggressive salivary gland adenocarcinoma, abundant eosinophilic (oncocytic) cytoplasm and AR, GATA3 & GCDFP15 positive! #pathology #pathsky #surgicalpathology #headandneckpathology #cytosky #salivaryductcarcinoma #sdc #pathart

Androgen receptor immunohistochemical stain

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EK MD, FCAP, FASCP, member of USCAP/ASC/PAPS @pathologist.bsky.social · 20/11/2024

Serous cystadenoma, pancreas, H&Es, 20x, 40x, 100x & DQ/PAP smears: Intracystic/intraluminal papillary projections lined by bland flattened to cuboidal epithelium - EMA, MUC1, inhibin, GLUT1 positive! #pathology #pathsky #surgicalpathology #cytosky #pancreaticpathology #serouscystadenoma #pathart

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EK MD, FCAP, FASCP, member of USCAP/ASC/PAPS @pathologist.bsky.social · 20/11/2024

Ameloblastoma (follicular type), mandible, H&Es, 20x and 40x: Epithelial nests with a peripheral layer of columnar cells showing "palisading" and "reverse polarity", surrounding a central area resembling the “stellate reticulum” of a developing tooth! #pathology #pathsky #surgicalpathology #pathart

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EK MD, FCAP, FASCP, member of USCAP/ASC/PAPS @pathologist.bsky.social · 19/11/2024

Granular cell tumor (GCT), tongue, H&Es, 10x and 40x & CD68 and S100, 20x: Large round to oval tumor cells with indistinct eosinophilic, granular cytoplasm - CD68, S100, and SOX10 positive! #pathology #pathsky #surgicalpathology #granularcelltumor #gct #headandneckpathology #pathart

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EK MD, FCAP, FASCP, member of USCAP/ASC/PAPS @pathologist.bsky.social · 18/11/2024

Chromophobe renal cell carcinoma (ChRCC), kidney, H&Es, 20x and 40x, CK7, 20x: Plant-like tumor cells - Vimentin negative; CK7 and C-Kit positive! #pathology #pathsky #surgicalpathology #renalpathology #renalcellcarcinoma #renalpathology #RCC #kidneypathology #ChRCC #pathart

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EK MD, FCAP, FASCP, member of USCAP/ASC/PAPS @pathologist.bsky.social · 18/11/2024

Pulmonary Blastomycosis, BAL, Pap stain, 40x and GMS stain, 40x: caused by Blastomyces dermatitidis spores, broad-based budding yeasts with thick, refractile cell walls! #pathology #pathsky #cytopathology #cytosky #lungpathology #blastomycosis #pulomonaryblastomycosis #microbiology #pathart #cytoart

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EK MD, FCAP, FASCP, member of USCAP/ASC/PAPS @pathologist.bsky.social · 18/11/2024

Invasive Micropapillary Carcinoma (IMPC), breast, H&E, 10x and 40x: Mimics lymphovascular space invasion due to “empty/clear spaces” around the tumor cells! #pathology #pathsky #surgicalpathology #breastpathology #invasivemicropapillarycarcinoma #IMPC #pathart

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EK MD, FCAP, FASCP, member of USCAP/ASC/PAPS @pathologist.bsky.social · 17/11/2024

Poorly differentiated colonic adenocarcinoma, H&E, 20x

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