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Tim Cleland

@paleoproteomicist.bsky.social
191 followers 106 following 34 posts

Paleoproteomics • Mass Spectrometry

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Reposted by Tim Cleland
asher newsome @iondoctor.bsky.social · 10/07/2026
New paper from my lab, written by Jess Deng from her time here as a predoctoral fellow. This was my first time using coated blade spray and the first of many 3D prints for me (so old it's from before I printed everything gold color) analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
analyticalsciencejournals.onlinelibrary.wiley.com
Derivatization‐Enabled Detection of Formalin From Preserved Tissues Using Coated Blade Spray Mass Spectrometry
Formalin-fixed, fluid-preserved specimens in natural history collections offer invaluable scientific and cultural insight but pose genomic challenges due to molecular degradation and persistent chemi...
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Reposted by Tim Cleland
Magnus Palmblad @magnuspalmblad.bsky.social · 07/07/2026
Tired of AI-generated figures? I asked our talented scientific illustrator Manon Zuurmond to draw some of the instruments and lab equipment we missed in NIH's otherwise fantastic BioArt resource. First batch now available as CC BY. Free for everyone to use in publications: github.com/Center-for-P...
Drawings of various laboratory equipment (liquid chromatography system, mass spectrometers and a centrifuge).
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Tim Cleland @paleoproteomicist.bsky.social · 03/03/2026
It is true, if anyone is interested in collaborating on some FDR problems let me know. #proteomics
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Tim Cleland @paleoproteomicist.bsky.social · 19/01/2026
#teammassspec
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Reposted by Tim Cleland
PastelBio @pastelbio.bsky.social · 18/01/2026
Theropod: Software Tools to Analyze Externally Collected Selective Temporal Overview of Resonant Ions pubs.acs.org/doi/10.... --- #proteomics #prot-paper
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Tim Cleland @paleoproteomicist.bsky.social · 16/01/2026
Introducing Theropod. A set of python and R tools that I’ve put together to do STORI analysis with an external digital oscilloscope. pubs.acs.org/doi/10.1021/...
pubs.acs.org
Theropod: Software Tools to Analyze Externally Collected Selective Temporal Overview of Resonant Ions
Recent developments in charge detection mass spectrometry have allowed for the broad characterization of individual proteoforms and mixtures of proteoforms from individual ions collected in Orbitrap m...
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Reposted by Tim Cleland
asher newsome @iondoctor.bsky.social · 16/01/2026
You saw it at conferences all over 2025, now my latest construction is published online: a flexible, general-purpose, small molecule MS probe that fits into the tight spaces. (Yes, it's my favorite graphical abstract) pubs.acs.org/doi/full/10....
pubs.acs.org
Non-proximate, Hand-Held Probe with Positional Feedback for Real-Time Analysis of Three-Dimensional Object Surfaces
A variety of non-proximate mass spectrometry techniques have been implemented to sample organic analytes from distant surfaces, but they frequently risk signal carryover and loss by relying on unheate...
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Reposted by Tim Cleland
Zandra Fagernäs @zandraselina.bsky.social · 15/01/2026
Do you need to clean your teeth? And if so, how? 🦷 The answer is YES, at least for Pleistocene teeth. Here, we show you why that is the case, and find a couple of good methods: www.nature.com/articles/s41...
nature.com
Identification and removal of contamination in palaeoproteomic analysis of dental enamel - Scientific Reports
Scientific Reports - Identification and removal of contamination in palaeoproteomic analysis of dental enamel
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Tim Cleland @paleoproteomicist.bsky.social · 18/11/2025
This was a super fun time and it is always nice to talk about paleoproteomics.
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Tim Cleland @paleoproteomicist.bsky.social · 18/09/2025
#palaeoproteomics
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Tim Cleland @paleoproteomicist.bsky.social · 18/09/2025
I have a new paper with @iondoctor.bsky.social and other MCI, Carnegie Science, and Calvert Marine Museum colleagues where we analyzed 8 and 10 million year old Ecphora shell membranes. We found chitin and various gastropod specific peptides. www.app.pan.pl/article/item...
app.pan.pl
Protein and chitin preservation in polymeric sheets in Miocene <em>Ecphora gardnerae</em> shells from Maryland, USA - Acta Palaeontologica Polonica
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Reposted by Tim Cleland
asher newsome @iondoctor.bsky.social · 18/08/2025
My second paper with former fellow Tjasa is out now. The focus is about swabbing large plastic art objects to study their surfaces (so that anyone can do it for GCMS) but we also do NPDPI for real-time high-res MS www.nature.com/articles/s40...
nature.com
Non-destructive mass spectrometry of historical poly(vinyl chloride) object surfaces with swab analysis - npj Heritage Science
npj Heritage Science - Non-destructive mass spectrometry of historical poly(vinyl chloride) object surfaces with swab analysis
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Tim Cleland @paleoproteomicist.bsky.social · 17/07/2025
The impacts of microCT on preserved proteins is something we probably need to consider in the #palaeoproteomics community as well. theconversation.com/scientists-c...
theconversation.com
Scientists could be accidentally damaging fossils with a method we thought was safe
A common scanning method used to create ‘virtual copies’ of precious fossils could be erasing some of the crucial information held within.
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Reposted by Tim Cleland
Tim Cleland @paleoproteomicist.bsky.social · 09/07/2025
We published a new paper on enamel paleoproteomics from teeth up to 18 million years old from the Turkana Basin in Kenya. www.nature.com/articles/s41...
nature.com
Eighteen million years of diverse enamel proteomes from the East African Rift - Nature
The isolation of dental proteins from fossils deposited 1.5 million to 18 million years ago in the Turkana Basin in Kenya, a tropical region, demonstrate the promise of dental enamel for palaeoproteom...
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Reposted by Tim Cleland
Kevin Uno @kevinuno.bsky.social · 09/07/2025
Check out our new paper, led by former postdoc and current colleague Daniel Green on 18 Ma proteins in fossil teeth! Tim Cleland, a proteomics wizard, did the measurements. What's the take home? We hope to use protein fingerprints to study mammal and hominin phylogenetics! bit.ly/OldProteome
bit.ly
Eighteen million years of diverse enamel proteomes from the East African Rift - Nature
The isolation of dental proteins from fossils deposited 1.5 million to 18 million years ago in the Turkana Basin in Kenya, a tropical region, demonstrate the promise of dental enamel for palaeoproteom...
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Reposted by Tim Cleland
Frido Welker @fridowelker.bsky.social · 09/07/2025
Two great new studies out in @nature.com today, pushing back the recovery of dental enamel proteins to 21+ million years in the Arctic (www.nature.com/articles/s41...) and 18+ million years in East Africa (www.nature.com/articles/s41...).
nature.com
Eighteen million years of diverse enamel proteomes from the East African Rift - Nature
The isolation of dental proteins from fossils deposited 1.5 million to 18 million years ago in the Turkana Basin in Kenya, a tropical region, demonstrate the promise of dental enamel for palaeoproteom...
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Reposted by Tim Cleland
Riley Black 🏳️‍⚧️ 🦖 @restingdinoface.bsky.social · 09/07/2025
Are we ever going to say “Bingo! Dino DNA”? No. But there are other microbio clues about ancient creatures in the rock record, including proteins from 18 million years ago that may help work our relationships of extinct creatures. And it hints there are likely even older protein scraps out there.
nature.com
Eighteen million years of diverse enamel proteomes from the East African Rift - Nature
The isolation of dental proteins from fossils deposited 1.5 million to 18 million years ago in the Turkana Basin in Kenya, a tropical region, demonstrate the promise of dental enamel for palaeoproteom...
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Reposted by Tim Cleland
Nature @nature.com · 09/07/2025
Molecules from 20-million-year-old rhino-relative teeth are among the oldest ever sequenced go.nature.com/4lFx4KN
go.nature.com
Ancient proteins rewrite the rhino family tree — are dinosaurs next?
Molecules from 20-million-year-old teeth are among the oldest ever sequenced.
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Reposted by Tim Cleland
Meagan Mulcair, Ph.D. @drmeagan.bsky.social · 09/07/2025
The record for the oldest protein ever found has been smashed five-fold after analyzing ancient fossilized teeth 🦷 @paleoproteomicist.bsky.social @fridowelker.bsky.social @harvardpress.bsky.social @smithsonianmag.bsky.social @newscientist.com www.newscientist.com/article/2487...
newscientist.com
Oldest proteins yet recovered from 18-million-year-old teeth
The oldest protein fragments ever recovered have been extracted from fossilised teeth found in Kenya's Rift Valley, revealing the remains belonged to the ancient ancestors of rhinoceroses and elephant...
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Tim Cleland @paleoproteomicist.bsky.social · 09/07/2025
This is a super exciting day for paleoproteomics. In addition to our paper on Kenyan enamel, the Cappellini group published a complementary paper on 21-24 million year old enamel from the Arctic www.nature.com/articles/s41...
nature.com
Phylogenetically informative proteins from an Early Miocene rhinocerotid - Nature
Protein sequences from fossil tooth enamel of a rhinocerotid from Canada’s High Arctic are used to develop phylogenetic frameworks from a specimen too old to preserve ancient DNA.
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Tim Cleland @paleoproteomicist.bsky.social · 09/07/2025
We published a new paper on enamel paleoproteomics from teeth up to 18 million years old from the Turkana Basin in Kenya. www.nature.com/articles/s41...
nature.com
Eighteen million years of diverse enamel proteomes from the East African Rift - Nature
The isolation of dental proteins from fossils deposited 1.5 million to 18 million years ago in the Turkana Basin in Kenya, a tropical region, demonstrate the promise of dental enamel for palaeoproteom...
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Tim Cleland @paleoproteomicist.bsky.social · 01/06/2025
@iondoctor.bsky.social and I will be presenting our museum work at #ASMS2025
Image showing the Smithsonian Museum Conservation Institute logo with a pot containing a handheld ambient analysis probe for Asher Newsome’s ASMS poster on Monday and his panelist at the Ambient workshop on Wednesday. There is also a moose silhouette with a pink femur for Timothy Cleland’s poster on Thursday and lightning talk at the Art, Museums and Archaeology workshop on Tuesday.
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Reposted by Tim Cleland
Welker Group @welkergroup.bsky.social · 24/04/2025
New publication! 🎉 Here you can read all about dog drool, bleach, and a probable Central Asian Neanderthal child: doi.org/10.1016/j.ja...
Graphical abstract of the publication.
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Reposted by Tim Cleland
Matthew Collins @matthewcollins.bsky.social · 21/01/2025
10th Bone Diagenesis Meeting, to be held in Athens, Greece 🇬🇷, on 24–26 September 2025 American School of Classical Studies at Athens (ASCSA) bd-2025.com Abstract submission is now open! more information here: bd-2025.com/abstracts
bd-2025.com
10th International Bone Diagenesis Meeting
It is with great pleasure that we invite you to the 10th Bone Diagenesis Meeting, to be held in Athens, Greece on 24-26 September 2025. Our meeting will take place at the premises of the American Scho...
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Reposted by Tim Cleland
ISBA11 Turin @isba11.bsky.social · 14/01/2025
ALERT! ⚠️🚨 The deadline for the ISBA11 abstract submission is quickly approaching - January 20th! CLICK HERE TO SUBMIT YOUR ABSTRACT www.isba11.com/abstract-sub... #archaeology #biomoleculararchaeology #ISBA #ISBA11 #archaeologists @isbarchaeology.bsky.social @archaeobiomics.bsky.social
isba11.com
Abstract Submission – ISBA 2025
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Tim Cleland @paleoproteomicist.bsky.social · 08/01/2025
#Palaeoprot
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Tim Cleland @paleoproteomicist.bsky.social · 08/01/2025
First paper of 2025 with Katja Diaz-Granados and other MCI people. We identify llama or alpaca fibers and natural dyes from Chancay textiles from Peru. pubs.acs.org/doi/10.1021/...
pubs.acs.org
Investigation of Natural Dyes and Taxonomic Identification of Fibers Used in Chancay Textiles by Vibrational Spectroscopy and Mass Spectrometry
Textiles provide a valuable source of information regarding past cultures and their artistic practices. Understanding ancient textiles requires identifying the raw materials used, since the origin of ...
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Reposted by Tim Cleland
asher newsome @iondoctor.bsky.social · 06/01/2025
First paper of 2025 is now online, a collaboration between former pre-doctoral intern Katja and several of us Smithsonian MCI people: pubs.acs.org/doi/10.1021/...
pubs.acs.org
Investigation of Natural Dyes and Taxonomic Identification of Fibers Used in Chancay Textiles by Vibrational Spectroscopy and Mass Spectrometry
Textiles provide a valuable source of information regarding past cultures and their artistic practices. Understanding ancient textiles requires identifying the raw materials used, since the origin of ...
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Reposted by Tim Cleland
Matthew Collins @matthewcollins.bsky.social · 15/10/2023
More than 136 people so far have joined PAASTA (Palaeoproteomics And Archaeology, Society for Techniques and Advances) an open, collaborative ECR-driven community for palaeoproteomics researchers. Contact Zandra Fagernäs, Copenhagen for an invite link to their Slack space.
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