Our latest paper is out! It describes mutations from >32,000 isolates, mapped on the 3D structures of ESX-1 related proteins: journals.asm.org/doi/full/10....
journals.asm.org
Single nucleotide variation catalog from clinical isolates mapped on tertiary and quaternary structures of ESX-1-related proteins reveals critical regions as putative Mtb therapeutic targets | Microbi...
We mapped all non-synonymous single nucleotide polymorphisms onto each of the experimental
and predicted ESX-1 proteins’ structural models and inspected their placement. Varying
sizes of conserved reg...