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OpenCravat.bsky.social @opencravat.bsky.social · 31/01/2026

Post 4/4 Hosted MCP endpoint: mcp.opencravat.org/sse (not a web page). Claude: connect MCP server → URL above → No Auth → enable tools. ChatGPT: Settings → Apps → Developer Mode → Create App → URL above → No Auth. Also open source + runnable locally.

mcp.opencravat.org

OpenCravat.bsky.social @opencravat.bsky.social · 31/01/2026

Post 3/4 Tools: coords, rsIDs, CAids, HGVS (g/c/p), protein missense → genomic HGVS via SynVar, + discover annotators/output fields. Uses GRCh38/hg38 + public OpenCRAVAT annotation service.

OpenCravat.bsky.social @opencravat.bsky.social · 31/01/2026

Post 2/4 More than “lookup”: give it a variant (rsID/HGVS/coords) and it returns clinical assertions (ClinVar/ClinGen, CIViC), population freqs (gnomAD + cohorts), effect predictors, + specialized resources (e.g., BRCA1 functional assay scores). Research/decision support ≠ clinical confirmation.

OpenCravat.bsky.social @opencravat.bsky.social · 31/01/2026

Post 1/4 🚀 Announcing the OpenCRAVAT MCP Server — variant annotation for AI tools via the Model Context Protocol (MCP). Lets LMs/clients call tools so they can fetch authoritative annotations on demand (not from model memory).

OpenCravat.bsky.social @opencravat.bsky.social · 18/12/2025

Looking for new ways to enrich your variant data? 🔍 We’ve made it simple to browse the OpenCRAVAT ecosystem. From ClinVar and gnomAD to calibrated variant effect predictions and visualization widgets, see what the store has to offer! 🍌 ocstore.opencravat.org #Genomics #VariantAnnotation #BioSky

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OpenCravat.bsky.social @opencravat.bsky.social · 16/10/2025

Discover the latest updates and project status of OpenCRAVAT by exploring the roadmap available on GitHub. Stay informed about the progress and developments by visiting this link: [OpenCRAVAT Roadmap](github.com/orgs/Karchin...). #annotator #opencravat #bioinformatics #opensource #genomics 🧬 🧪 🖥️

github.com

OpenCRAVAT Roadmap • KarchinLab

This is the roadmap for the OpenCRAVAT Project.

OpenCravat.bsky.social @opencravat.bsky.social · 19/09/2025

; (3) run non-sensitive analyses locally and scale compute in cloud for bulk jobs; (4) automate QC and reporting templates; (5) train non-programmer staff using the GUI. #annotator #opencravat #bioinformatics #opensource #genomics

OpenCravat.bsky.social @opencravat.bsky.social · 19/09/2025

Stuck with a three-month VCF backlog? Try these five rapid changes to cut turnaround time in half. (1) prioritize with calibrated predictors; (2) use OpenCRAVAT modular annotators to remove tool fragmentation#annotator #opencravat #bioinformatics #opensource #genomics🧬 🖥️ 🧪

OpenCravat.bsky.social @opencravat.bsky.social · 23/08/2025

We are planning to launch a new collection of Jupyter notebooks and would love to know if you're interested. If so, please share topics or features you'd like included. Your feedback will help us tailor these notebooks to your needs and preferences.#annotator #opencravat #opensource 🧬 🧪 🖥️

OpenCravat.bsky.social @opencravat.bsky.social · 22/08/2025

Introducing our latest offering: the Calibrated Classification Package for clinical interpretation of variant effect predictor scores. This innovative package aids users in applying ACMG/AMP variant interpretation guidelines.#annotator #opencravat #bioinformatics #opensource #genomics 🧬 🧪 🖥️

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OpenCravat.bsky.social @opencravat.bsky.social · 15/08/2025

Help shape the future of genomic variant annotation! We’re looking for community contributors to support OpenCRAVAT — from testing new features to improving documentation and outreach. 📝 Sign up here: forms.gle/v5t2ErBxYzqn... #Genomics #Bioinformatics #OpenScience #Annotation

forms.gle

OpenCRAVAT Community Contributor Interest Form

Help shape the future of genomic variant annotation! We’re looking for members of the genomics, bioinformatics, and clinical variant interpretation community to help improve OpenCRAVAT. As a…

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OpenCravat.bsky.social @opencravat.bsky.social · 07/07/2025

Would you be interested in organizing or speaking at meetups, writing blog posts, or promoting the project? Are you part of any communities or organizations where you could share our project? #annotator #opencravat #bioinformatics #opensource #genomics

OpenCravat.bsky.social @opencravat.bsky.social · 07/07/2025

Would you be open to helping improve documentation or writing user guides? Do you have skills in UI/UX design, and would you be interested in helping us improve the user interface? #annotator #opencravat #bioinformatics #opensource #genomics

OpenCravat.bsky.social @opencravat.bsky.social · 07/07/2025

Would you be willing to review pull requests or help triage GitHub issues? Can you help test new features or provide feedback on pre-release versions? Would you be interested in setting up automated test cases or improving test coverage? #annotator #opencravat #bioinformatics #opensource #genomics

OpenCravat.bsky.social @opencravat.bsky.social · 07/07/2025

We are seeking community members interested in taking part in OpenCRAVAT's future. Let us know if you might contribute in any of these areas: Would you be interested in contributing code, bug fixes, or performance improvements? Are there features or issues you’d like to help implement or debug?🧬🖥️

OpenCravat.bsky.social @opencravat.bsky.social · 01/07/2025

🧪 🧬 Want to explore your own genome? Join our free webinar on how to use OpenCRAVAT to annotate & interpret your personal variants. 📅 July 10 | 🕐 1 PM EDT 🎙️ With Jasmine Baker, PhD & Rachel Karchin, PhD 🔗 tinyurl.com/3ur6vv35 #Genomics #Bioinformatics #OpenSource #OpenCRAVAT🖥️

tinyurl.com

Welcome! You are invited to join a webinar: Exploring Personal Genomes with OpenCRAVAT. After registering, you will receive a confirmation email about joining the webinar.

One-hour webinar teaching how to utilize OpenCRAVAT as an annotation tool for personal genomic data.

OpenCravat.bsky.social @opencravat.bsky.social · 16/06/2025

🧬 Curious about your genome? Join our free webinar on OpenCRAVAT to explore and annotate your own data! 📅 July 10 – 1 PM EDT 🎙️ Baker & Karchin (JHU) 🔗 tinyurl.com/3ur6vv35 #Genomics #Bioinformatics #OpenScience #annotator #opencravat #bioinformatics #opensource #webinar #genomes 🖥🧪

OpenCravat.bsky.social @opencravat.bsky.social · 10/06/2025

Ever wonder what secrets your personal genome might hold? 🧬 Join us live on July 10 to explore how OpenCRAVAT helps annotate your data & turn it into meaningful insight. Perfect for researchers & curious minds alike. 🔬 Registration link coming soon!🖥

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OpenCravat.bsky.social @opencravat.bsky.social · 07/06/2025

Discover the power of OpenCRAVAT's cutting-edge annotation features that ensure seamless collaboration among users. Its intuitive design makes it easy for everyone to navigate, while enhancing productivity across the board.#annotator #opencravat #bioinformatics #opensource #genomics 🖥️ 🧬

OpenCravat.bsky.social @opencravat.bsky.social · 01/06/2025

Discover the power of the All of Us annotator with Open Cravat! This tool uses allele frequency data from the All of Us Research Program to explore genetic variations in diverse populations, enhancing precision medicine. Let's innovate healthcare together! #PrecisionMedicine #Genomics #AllOfUs🖥️ 🧬

OpenCravat.bsky.social @opencravat.bsky.social · 01/06/2025

Introducing the Regeneron Million Exome Annotator curated by Regeneron Genetics Center. Developed with major biobanks and health systems, it provides valuable genetic insights for research. We encourage its use in your research toolkit. #annotator #bioinformatics #opensource #genomics 🧪 🖥️🧬

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OpenCravat.bsky.social @opencravat.bsky.social · 18/04/2025

Need variant annotation fast? OpenCRAVAT makes it easy—whether you're analyzing one variant or thousands. Free, flexible, and built for discovery. Try it today at opencravat.org 🧪🖥🧬

opencravat.org

OpenCRAVAT

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OpenCravat.bsky.social @opencravat.bsky.social · 21/03/2025

The cat is out of the bag! We are excited to be a part of this collaboration. Global democratization of deidentified allele count + frequency data with population breakdown from the first ~250k short-read WGS in All of Us designed to plug straight into clinical workflows.🖥️🧪🧬

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OpenCravat.bsky.social @opencravat.bsky.social · 11/03/2025

🖥️ New to OpenCRAVAT? Explore our Vignettes—tutorials designed for easy genomic variant analysis! 🧬 📖 Learn to: ✅ Annotate variants ✅ Interpret results for clinical & research ✅ Utilize powerful analysis tools Start here: karchinlab.github.io/oc_vignettes/ #Genomics #VariantAnnotation #OpenSource

OpenCravat.bsky.social @opencravat.bsky.social · 22/02/2025

🧬 We Want Your Feedback! 🧬\ Do you use variant annotation software? We’re gathering insights from the genomics community to improve OpenCRAVAT and understand what features matter most to you.💡 Take this quick survey (it takes less than 2 minutes!): shorturl.at/iOvMt

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OpenCravat.bsky.social @opencravat.bsky.social · 19/01/2025

Have you seen our updated website? Head over to opencravat.org and check it out! 🖥🧪

buff.ly

OpenCRAVAT

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OpenCravat.bsky.social @opencravat.bsky.social · 14/01/2025

Do you have research goals for 2025!? We'd love to hear them! #annotation #OpenCRAVAT #2025 🧪🖥

OpenCravat.bsky.social @opencravat.bsky.social · 06/01/2025

❗We are experiencing a power outage at our data center due to the polar vortex. All OpenCRAVAT systems are currently down. We will update as systems come back online.

OpenCravat.bsky.social @opencravat.bsky.social · 12/12/2024

Day 12: 🎉 A Genomic Variant Community Our community is at the heart of everything we do. From researchers to clinicians, your feedback shapes OpenCRAVAT's future. Join us in celebrating our shared journey in variant annotation. 💬 Connect with us: buff.ly/3ZQ1MZT 🖥️ 🧬 #Community #Genomics

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OpenCravat.bsky.social @opencravat.bsky.social · 11/12/2024

⚙️ Day 11: Widgets That Work for You! Customization is 🔑! OpenCRAVAT’s widgets allow you to visualize variant data in a way that makes sense for your workflow. 🌐 Explore widgets: buff.ly/3DbcEbK What’s your favorite widget? #12DaysOfOpenCRAVAT #GenomicTools #Visualization🖥️ 🧬

OpenCravat.bsky.social @opencravat.bsky.social · 10/12/2024

🧬 New Blog by Dr. Rachel Karchin! Dr. Karchin shares how OpenCRAVAT and CIViC are addressing transparency and interpretability in variant effect predictors. Discover how calibrated predictors are transforming clinical variant classification. 🖥️ 🔗 Read the full post:

buff.ly

Variant effect predictors in the clinic: Working with calibrated predictors in OpenCRAVAT

Computational methods for predicting the effects of genetic variants are used by clinicians for interpreting genetic test results and by researchers for scientific exploration. However, their utility…

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OpenCravat.bsky.social @opencravat.bsky.social · 10/12/2024

🌐 On the 10th day of #OpenCRAVAT, my workflow gave to me… ✨ Powerful API Capabilities! Integrate OpenCRAVAT into pipelines: submit jobs, check statuses, and fetch custom reports programmatically. Explore the API docs: buff.ly/4g8lMfP #12DaysofOpenCRAVAT #Genomics

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OpenCravat.bsky.social @opencravat.bsky.social · 10/12/2024

☁️ Day 9 of #OpenCRAVAT: Run on the Cloud! No hardware limits, no delays—just efficient genomic analysis anywhere. Learn how to set up OpenCRAVAT on the cloud today. 🔗Cloud Usage: buff.ly/3BjGavq #12DaysofOpenCRAVAT #CloudComputing 🖥️ 🧬 #Genomics #Variants

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OpenCravat.bsky.social @opencravat.bsky.social · 09/12/2024

Which filter is most useful for your research? Comment below!🔗Filtering Tutorial: docs.opencravat.org/en/latest/Filte… #12DaysofOpenCRAVAT #VariantAnalysis 🧬 🖥️

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OpenCravat.bsky.social @opencravat.bsky.social · 09/12/2024

🔎 Day 8: Eight Data Filtering Options! Refine your results with precision: filter by gene, variant type, pathogenicity score, or population frequency.🧵 #12DaysofOpenCRAVAT #VariantAnalysis 🧬 🖥️

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OpenCravat.bsky.social @opencravat.bsky.social · 07/12/2024

Day 7: Personalize your analysis with OpenCRAVAT! Access numerous annotation tools and refine your focus on certain genes or variants using filters. Automate tasks with Python scripts. Choose input formats.. Export results. Try it locally or in the cloud. #Genomics #VariantAnalysis

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OpenCravat.bsky.social @opencravat.bsky.social · 07/12/2024

🌟 On the 6th day of #OpenCRAVAT, my database gave to me…Six Gene-Level Insights! Which insight is most valuable for your research? CHASMplus, REVEL, PolyPhen-2, @gnomad-project.bsky.social, ClinVar, or COSMIC? Explore OpenCRAVAT at opencravat.org #Genomics #VariantAnalysis #OpenCRAVAT 🧬 🖥️

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OpenCravat.bsky.social @opencravat.bsky.social · 05/12/2024

On the 5th day of #OpenCRAVAT, my platform gave to me… ✨ Five Tips for New Users! New to OpenCRAVAT? Check out the links in this thread. Got questions? Comment below! #12DaysofOpenCRAVAT #Genomics #OpenData #Variants #Annotation

OpenCravat.bsky.social @opencravat.bsky.social · 04/12/2024

❄️ On the 4th day of #OpenCRAVAT, my workflow gave to me… Four Annotation Sources! Discover how gnomAD4, dbSNP, ClinVar, and COSMIC make your variant analysis powerful. Which do you rely on most? Link to full list of annotators: docs.opencravat.org/en/latest/#avai…

OpenCravat.bsky.social @opencravat.bsky.social · 03/12/2024

✨ On the 3rd day of #OpenCRAVAT, my tools gave to me… 🎄 Three Custom Report Options! Choose from TXT, Excel, or Sqlite outputs to fit your workflow. Which report type is your favorite? Reply below! 🔗https://buff.ly/3VlpryC 🔗https://buff.ly/4iewYJj #12DaysofOpenCRAVAT #Genomics #VariantAnalysis