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Olivier Parent

@oparent.bsky.social

119 followers 129 following 15 posts

PhD student working on MRI markers of vascular dysfunction in aging - McGill University - Douglas Research Center

Olivier Parent @oparent.bsky.social · 26/05/2026

Striking sex differences in WMH pathophysiology, with females having more WMHs but similar pathophysiological effects in anterior regions, while males show higher WMH volumes but lower pathophysiological effects in posterior regions

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Olivier Parent @oparent.bsky.social · 26/05/2026

The posterior WMH region is structurally connected to cortical regions susceptible to early Tau accumulation (i.e., the medial temporal lobe)

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Olivier Parent @oparent.bsky.social · 26/05/2026

Specific pathophysiological effects in WMHs of individuals with AD, as opposed to cerebrovascular disease: similar fractional anisotropy (FA) to controls, lower orientation dispersion (OD), consistent with selective fiber degeneration. This finding was replicated in ADNI

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Olivier Parent @oparent.bsky.social · 26/05/2026

A fully data-driven parcellation of WMHs based on voxel-wise pathophysiology (available at github.com/CoBrALab/WMH...) revealed an anterior-to-posterior WMH gradient, rather than purely periventricular/deep

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Olivier Parent @oparent.bsky.social · 26/05/2026

We explored whether we could find vascular vs neurodegenerative WMH patterns using in vivo clinically-applicable tools, specifically microstructural MRI markers (DTI, NODDI, T2*, QSM) applied in a large, diverse cohort (UK Biobank, n=32,000). Important findings:

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Olivier Parent @oparent.bsky.social · 31/03/2025

ADPD! I'm excited to present the complete story of my WMH research: "Uncovering spatial pathophysiological patterns of white matter hyperintensities of neurodegenerative origins", including a cool new tractography analysis! Tue April 1st, Hall A, 12:45 #ADPD

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