Reposted by @oliolabs.bsky.socialDavid Tingley @davidtingley.bsky.social · 19/03/2025Some really cool work we've been doing @oliolabs.bsky.social. New science opens the door to better medicines. 171
oliolabs.bsky.social @oliolabs.bsky.social · 19/03/2025We are building our platforms to solve these problems, and deliver better outcomes with fewer side effects to more people. Get in touch if you want to be a part of our vision. www.oliolabs.co 000
oliolabs.bsky.social @oliolabs.bsky.social · 19/03/2025Check out a write up of the results here: t.co/ZYakrIhPTE Link to PDF here: t.co/VwqiZ46eHUt.cohttps://www.prnewswire.com/news-releases/landmark-study-explains-why-obesity-drugs-work-differently-for-women-and-men-302406164.html 100
oliolabs.bsky.social @oliolabs.bsky.social · 19/03/2025We also found that side effects fluctuate with estrogen levels and estrous cycle phases in humans and mice respectively 100
oliolabs.bsky.social @oliolabs.bsky.social · 19/03/2025GLP-1 receptor expression is higher in females than males in parts of the brain associated with pain and nausea 100
oliolabs.bsky.social @oliolabs.bsky.social · 19/03/2025Female rats and mice display significantly more nausea-associated behavior compared to males (Kaolin intake is a measure of nausea in rats) 100
oliolabs.bsky.social @oliolabs.bsky.social · 19/03/2025Women taking GLP1-R agonists experience more than twice the rate of persistent nausea and vomiting compared to men 100
oliolabs.bsky.social @oliolabs.bsky.social · 19/03/2025Check out what we're working on at Olio Labs! 70% of patients taking GLP-1's (like Ozempic) are women, but they experience >2x side effect rates than men. What is driving this difference? We combine human EMR data, mouse & rat behavior, and scRNAseq to figure it out: 141
