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Olivier Wouters

@ojwouters.bsky.social
366 followers 75 following 0 posts

Associate Professor at Brown University Investigating global disparities in access to medicines

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Reposted by Olivier Wouters
Jose Figueroa, MD, MPH @joefigs.bsky.social · 13/12/2024
Interesting new @thelancet.bsky.social study by H. Naci @lsehealthpolicy.bsky.social & I. Papanicolas @Brown Study shows tradeoffs in England of covering costly new drugs at the expense of not covering existing drugs/services in NHS. Result: Less health gains www.thelancet.com/journals/lan...
thelancet.com
Population-health impact of new drugs recommended by the National Institute for Health and Care Excellence in England during 2000–20: a retrospective analysis
During 2000–20, NHS coverage of new drugs displaced more population health than it generated. Our results highlight the inherent trade-offs between individuals who directly benefit from new drugs and those who forgo health due to the reallocation of resources towards new drugs.
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Reposted by Olivier Wouters
Kevin Outterson @koutterson.bsky.social · 09/12/2024
Access to essential medicines is not improving over the past 4 decades with existing tools. "The gap between richer (high- and upper-middle-income) and poorer (lower-middle- and low-income) countries remained largely unchanged over time." www.healthaffairs.org/doi/epdf/10....
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Reposted by Olivier Wouters
JAMA @jama.com · 02/12/2024
Reductions in prices associated with the Medicare Drug Price Negotiation Program differed widely across the 10 drugs. The negotiated prices of all products but 1 remained above list prices in peer countries. ja.ma/3B9rsXF
Figure: Comparison of treatment costs based on prices negotiated by Medicare, initial net prices, and ceiling prices.
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Reposted by Olivier Wouters
William Feldman @wbfeldman.bsky.social · 25/11/2024
New paper out at @jamacurrent.bsky.social led by @ojwouters.bsky.social on the empirical assumptions underlying differential protection for biologics & small-molecule drugs. Upshot: We found no good evidence supporting differential treatment by FDA (or under IRA). jamanetwork.com/journals/jam...
jamanetwork.com
Legal Protections for Biologics vs Small-Molecule Drugs in the US
This Special Communication analyzes and compares development times, clinical trial success rates, research and development costs, patent protection, market exclusivity periods, revenues, and treatment...
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Reposted by Olivier Wouters
Aaron Kesselheim @akesselheim.bsky.social · 23/11/2024
Relevant to accelerated approval, new DCE from former @portalresearch.org fellow Huseyin Naci et al examined patient views on survival benefit for cancer drugs: "individuals expressed strong preferences for certainty that a cancer drug would offer survival benefit" www.thelancet.com/journals/lan...
thelancet.com
Preferences for speed of access versus certainty of the survival benefit of new cancer drugs: a discrete choice experiment
Many cancer drugs approved through the FDA's accelerated approval pathway do not offer any survival benefit to patients. In this study, individuals expressed strong preferences for certainty that a ca...
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