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Neuroscience Research Highlights

@nsrhighlights.bsky.social
119 followers 667 following 201 posts

Neuroscience Research 掲載論文の新しい発見を、研究者にも一般の方にも届く形で紹介します。Independent, unofficial account sharing discoveries from papers published in Neuroscience Research. www.sciencedirect.com/journal/neuro…

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Neuroscience Research Highlights @nsrhighlights.bsky.social · 15h
Remembering and waiting may be different prefrontal jobs. In two monkeys, reduced prefrontal activity caused more early gaze breaks while target direction stayed accurate. doi.org/10.1016/j.neures.2025.105010 #NeuroscienceResearch #Neuroscience #WorkingMemory
Japanese painterly NSR cover showing a recognizable dorsolateral prefrontal cortical target; a delay-period fixation gate; and increased breaks across tasks while directional-choice arrows remain stable. The canonical explorer holds position at the delay gate and notes when gaze paths break before the choice. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 15h
「覚えておく」と「合図まで待つ」は、同じ脳の働きでしょうか。2頭のサルで前頭前野の一部を一時的に抑えると、覚えた方向は保てた一方、待機中に視線を外す失敗が増えました。 doi.org/10.1016/j.neures.2025.105010 #NeuroscienceResearch #Neuroscience #WorkingMemory
Japanese painterly NSR cover showing a recognizable dorsolateral prefrontal cortical target; a delay-period fixation gate; and increased breaks across tasks while directional-choice arrows remain stable. The canonical explorer holds position at the delay gate and notes when gaze paths break before the choice. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 01/10/2026
New three- and four-electrode probes delivered genes more symmetrically to both sides of the embryonic mouse brain, with configurable cortical and hippocampal targets. doi.org/10.1016/j.neures.2025.105009 #NeuroscienceResearch #Neuroscience #Neurotech
Japanese painterly NSR cover showing a recognizable embryonic mouse brain with left and right hemispheres; three- and four-electrode geometries; and approximately symmetric bilateral expression fields. The canonical explorer aligns the electrode geometry on a transparent map without touching the embryo. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 01/10/2026
胎生マウス脳の左右へ、同時に遺伝子を届ける。新しい3極・4極プローブは電気の流れを組み替え、皮質や海馬の狙った領域に、従来より対称で再現性の高い発現を作りました。 doi.org/10.1016/j.neures.2025.105009 #NeuroscienceResearch #Neuroscience #Neurotech
Japanese painterly NSR cover showing a recognizable embryonic mouse brain with left and right hemispheres; three- and four-electrode geometries; and approximately symmetric bilateral expression fields. The canonical explorer aligns the electrode geometry on a transparent map without touching the embryo. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 30/09/2026
In writer's cramp, which disrupts handwriting, patients benefited from repeating finger sequences despite making more wrong or missed button presses. Sep 28, 2026 doi.org/10.1016/j.neures.2026.105125 #NeuroscienceResearch #Neuroscience
和紙の風合いの和風イラスト。人の手が4つの色付きボタンに指を置き、そばに規則的な色の並びと不規則な並びを描いた紙がある。猫の探検家が虫眼鏡で繰り返し模様を観察し、奥にはMRI装置が見える。指の順序を学ぶことと動作の正確さを分けて調べる研究の概念画で、実際の実験データや脳活動画像ではない。和紙看板にNeuroscience Research。
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 30/09/2026
字を書くときに手が意思どおりに動かなくなる「書痙」。患者さんにも、繰り返される指の動きの順序を学ぶ効果が見られました。一方、押し間違いと押し忘れを合わせた割合は高くなっていました。 2026.9.28 doi.org/10.1016/j.neures.2026.105125 #NeuroscienceResearch #Neuroscience
和紙の風合いの和風イラスト。人の手が4つの色付きボタンに指を置き、そばに規則的な色の並びと不規則な並びを描いた紙がある。猫の探検家が虫眼鏡で繰り返し模様を観察し、奥にはMRI装置が見える。指の順序を学ぶことと動作の正確さを分けて調べる研究の概念画で、実際の実験データや脳活動画像ではない。和紙看板にNeuroscience Research。
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 29/09/2026
Calmer brain waves did not mean full recovery. In mice exposed to sarin below a lethal dose, antidotes stabilized resting brain rhythms, but memory problems remained. doi.org/10.1016/j.neures.2025.105013 #NeuroscienceResearch #Neuroscience #Neurotoxicology
Japanese painterly NSR cover showing a resting EEG wave returning toward stability; a separate memory-task path that remains disrupted; and a delayed antidote time gate after nonconvulsive exposure. The canonical explorer compares the recovering wave ribbon with the still-blocked memory path. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 29/09/2026
脳波が落ち着けば、脳の機能も戻ったと言えるのでしょうか。致死量未満のサリンに曝露したマウスでは、解毒薬で安静時の脳波が安定しても、記憶障害は残りました。 doi.org/10.1016/j.neures.2025.105013 #NeuroscienceResearch #Neuroscience #Neurotoxicology
Japanese painterly NSR cover showing a resting EEG wave returning toward stability; a separate memory-task path that remains disrupted; and a delayed antidote time gate after nonconvulsive exposure. The canonical explorer compares the recovering wave ribbon with the still-blocked memory path. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 28/09/2026
In a brainstem-seeded mouse model, REM-sleep abnormalities appeared before motor deficits and dopamine-neuron loss. doi.org/10.1016/j.neures.2026.105023 #NeuroscienceResearch #Neuroscience #Parkinsons
Japanese painterly NSR cover showing a brainstem-to-motor time path in a mouse model; an early disrupted sleep gate; and later motor imbalance and dopaminergic-cell loss markers kept downstream in time. The canonical explorer walks along the timeline, pausing first at the sleep gate and later at the motor gate. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 28/09/2026
運動障害が現れる前に、睡眠の異常を捉えられるでしょうか。変異型αシヌクレイン線維を脳幹へ入れたマウスでは、REM睡眠中の異常が先に現れ、その後に運動障害とドーパミン神経の減少が続きました。 doi.org/10.1016/j.neures.2026.105023 #NeuroscienceResearch #Neuroscience #Parkinsons
Japanese painterly NSR cover showing a brainstem-to-motor time path in a mouse model; an early disrupted sleep gate; and later motor imbalance and dopaminergic-cell loss markers kept downstream in time. The canonical explorer walks along the timeline, pausing first at the sleep gate and later at the motor gate. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 27/09/2026
ERK activity in awake mouse cortex was not only stimulus-driven: spontaneous single, repeated, and sustained signals appeared, and some neurons changed together. doi.org/10.1016/j.neures.2026.105032 #NeuroscienceResearch #Neuroscience #ERK
Japanese painterly NSR cover showing a field of awake cortical cells; distinct single, repeated, and sustained ERK pulse patterns; and a subset of neighboring excitatory neurons with synchronized pulses. The canonical explorer watches several cell lanterns and marks when their pulse rhythms align or diverge. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 27/09/2026
覚醒中の脳で、細胞内のERK信号は刺激を待っているだけではありませんでした。マウス皮質を長時間観察すると、刺激なしでも単発・反復・持続する活動が現れ、一部の神経細胞では活動が同期しました。 doi.org/10.1016/j.neures.2026.105032 #NeuroscienceResearch #Neuroscience #ERK
Japanese painterly NSR cover showing a field of awake cortical cells; distinct single, repeated, and sustained ERK pulse patterns; and a subset of neighboring excitatory neurons with synchronized pulses. The canonical explorer watches several cell lanterns and marks when their pulse rhythms align or diverge. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 26/09/2026
What keeps developing cortical neurons inside the brain’s outer boundary? In mice, CD81 linked neuronal GPR56 signaling with a collagen III scaffold in the meninges. doi.org/10.1016/j.neures.2026.105035 #NeuroscienceResearch #Neuroscience #Cortex
Japanese painterly NSR cover showing a recognizable layered developing cortical wall; three interacting CD81, GPR56, and collagen-III conceptual forms; and a cortical-boundary defect in the double-knockout comparison. The canonical explorer compares an intact cortical boundary with a disrupted one while tracing the three-part interaction. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 26/09/2026
発達中の大脳皮質で境界はどう保たれる? マウスでは、膜タンパク質CD81が神経側のGPR56や髄膜側のコラーゲンIIIと協調し、皮質の境界と層構造を支えることが示されました。 doi.org/10.1016/j.neures.2026.105035 #NeuroscienceResearch #Neuroscience #Cortex
Japanese painterly NSR cover showing a recognizable layered developing cortical wall; three interacting CD81, GPR56, and collagen-III conceptual forms; and a cortical-boundary defect in the double-knockout comparison. The canonical explorer compares an intact cortical boundary with a disrupted one while tracing the three-part interaction. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 25/09/2026
In noise-exposed mice, a multicomponent herbal formulation reached the inner ear, reduced worsening of auditory brainstem responses, and lowered an oxidative-stress marker. doi.org/10.1016/j.neures.2026.105043 #NeuroscienceResearch #Neuroscience #Hearing
Japanese painterly NSR cover showing a recognizable cochlear spiral; auditory response waves before and after treatment-associated attenuation; and localized oxidative-stress sparks reduced in the comparison condition. The canonical explorer listens at the cochlear spiral and compares two response-wave ribbons without dispensing treatment. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 25/09/2026
騒音で傷んだ内耳へ、多成分の生薬製剤は届くのでしょうか。マウスでは複方丹参滴丸の成分が内耳へ移行し、音に対する脳幹反応の悪化が小さくなり、酸化ストレスの指標も低下しました。 doi.org/10.1016/j.neures.2026.105043 #NeuroscienceResearch #Neuroscience #Hearing
Japanese painterly NSR cover showing a recognizable cochlear spiral; auditory response waves before and after treatment-associated attenuation; and localized oxidative-stress sparks reduced in the comparison condition. The canonical explorer listens at the cochlear spiral and compares two response-wave ribbons without dispensing treatment. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 24/09/2026
Focal CRTC1 reduction in marmoset visual cortex changed rapid-response genes and fast electrical rhythms beyond the targeted area, while local tissue showed neurodegeneration. doi.org/10.1016/j.neures.2026.105042 #NeuroscienceResearch #Neuroscience #CRTC1
Japanese painterly NSR cover showing a recognizable cortical sheet with a localized injection zone; concentric immediate-early-gene response zones extending outward; and transient high-frequency wave bursts alongside progressive tissue injury. The canonical explorer observes the expanding boundary from a safe overlook and records its changing phases. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 24/09/2026
霊長類の視覚野でCRTC1を局所的に減らすと、変化は周囲へ広がりました。マーモセットでは、神経活動に素早く反応する遺伝子と速い脳波リズムが変わり、局所で神経変性も進みました。 doi.org/10.1016/j.neures.2026.105042 #NeuroscienceResearch #Neuroscience #CRTC1
Japanese painterly NSR cover showing a recognizable cortical sheet with a localized injection zone; concentric immediate-early-gene response zones extending outward; and transient high-frequency wave bursts alongside progressive tissue injury. The canonical explorer observes the expanding boundary from a safe overlook and records its changing phases. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 23/09/2026
In mice given a lipid-lowering drug before an induced stroke, brain injury was milder: damaged tissue volume and neurological deficits were reduced at 48 hours. Sep 18, 2026 doi.org/10.1016/j.neures.2026.105121 #NeuroscienceResearch #Neuroscience
和紙の風合いの日本画風イラスト。白いマウスのそばで、猫の探検家が虫眼鏡を持ち、脳の形の紙模型に置かれた赤い血管と小さな留め具を観察する。脇に閉じた薬瓶と無地の札が並ぶ。マウスの一時的な脳血流遮断と事前投薬の研究を表す概念画で、実際の脳画像や治癒の描写ではない。下部にNeuroscience Researchの和紙看板。
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 23/09/2026
脂質を下げる薬を脳梗塞前から投与したマウスでは、脳の傷害が軽くなりました。48時間後に、梗塞の体積が小さく、神経症状も軽くなっていました。 2026.9.18 doi.org/10.1016/j.neures.2026.105121 #NeuroscienceResearch #Neuroscience
和紙の風合いの日本画風イラスト。白いマウスのそばで、猫の探検家が虫眼鏡を持ち、脳の形の紙模型に置かれた赤い血管と小さな留め具を観察する。脇に閉じた薬瓶と無地の札が並ぶ。マウスの一時的な脳血流遮断と事前投薬の研究を表す概念画で、実際の脳画像や治癒の描写ではない。下部にNeuroscience Researchの和紙看板。
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 21/09/2026
In six adults, wearable OPM-MEG detected a steady 30-Hz visual response near cortex, while slower transient signals were hidden by movement noise. doi.org/10.1016/j.neures.2026.105052 #NeuroscienceResearch #Neuroscience #MEG
Japanese painterly NSR cover showing a wearable OPM sensor array around the head; a 30-Hz checkerboard visual source; and contralateral steady-state response waves contrasted with low-frequency motion artifact. The canonical explorer balances an OPM lantern and an EEG lantern while watching the 30-Hz wave. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 21/09/2026
頭に装着する小型磁気センサーで、視覚刺激に同期する脳活動を測れる? 健康な成人6人では、ウェアラブルOPM-MEGが30Hzの定常応答を視覚野近くで捉えました。一方、遅い一過性応答は動きの雑音に隠れました。 doi.org/10.1016/j.neures.2026.105052 #NeuroscienceResearch #Neuroscience #MEG
Japanese painterly NSR cover showing a wearable OPM sensor array around the head; a 30-Hz checkerboard visual source; and contralateral steady-state response waves contrasted with low-frequency motion artifact. The canonical explorer balances an OPM lantern and an EEG lantern while watching the 30-Hz wave. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 20/09/2026
Can the timing of ultrasound pulses reverse their effect at the same acoustic intensity? In a 13-person pilot, two ten-pulse patterns shifted motor-evoked potentials in opposite directions. doi.org/10.1016/j.neures.2026.105055 #NeuroscienceResearch #Neuroscience #Ultrasound
Japanese painterly NSR cover showing two distinct decapulse ultrasound trains; a recognizable motor-cortex target; and motor-evoked-response ribbons diverging upward and downward. The canonical explorer stands between the two pulse trains and compares their opposite response directions. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 20/09/2026
同じ強さの超音波でも、パルスの並べ方で運動皮質の反応は逆になる? 健康な13人の予備研究では、2種類の10パルス刺激が、筋肉に現れる運動誘発電位を一方は高め、もう一方は低下させました。 doi.org/10.1016/j.neures.2026.105055 #NeuroscienceResearch #Neuroscience #Ultrasound
Japanese painterly NSR cover showing two distinct decapulse ultrasound trains; a recognizable motor-cortex target; and motor-evoked-response ribbons diverging upward and downward. The canonical explorer stands between the two pulse trains and compares their opposite response directions. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 19/09/2026
Autotaxin, a lipid-signal-producing enzyme, was not uniform in mouse brain. It stood out on the fluid-facing side of choroid plexus cells and in myelin-forming oligodendrocytes. doi.org/10.1016/j.neures.2026.105062 #NeuroscienceResearch #Neuroscience #BrainLipids
Japanese painterly NSR cover showing a recognizable choroid plexus facing a ventricular-CSF space; autotaxin-enriched apical epithelial surfaces; and a developmental shift toward oligodendrocyte-associated localization. The canonical explorer surveys the CSF-facing surface, then follows the age path toward oligodendrocytes. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 19/09/2026
脂質シグナルを作る酵素autotaxinは、脳内に一様ではありませんでした。マウスでは、髄液を作る脈絡叢の髄液側と、軸索を包むオリゴデンドロサイトで際立ち、発達に伴って分布が変わりました。 doi.org/10.1016/j.neures.2026.105062 #NeuroscienceResearch #Neuroscience #BrainLipids
Japanese painterly NSR cover showing a recognizable choroid plexus facing a ventricular-CSF space; autotaxin-enriched apical epithelial surfaces; and a developmental shift toward oligodendrocyte-associated localization. The canonical explorer surveys the CSF-facing surface, then follows the age path toward oligodendrocytes. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 18/09/2026
Mice making a disease-linked protein in a smell-processing brain region struggled to distinguish patterns, despite little detectable protein in visual areas. 📅 Published: Sep 11, 2026 🔗 doi.org/10.1016/j.neures.2026.105118 #NeuroscienceResearch #Neuroscience
和室の木製T字迷路で、黒いマウスが縦縞と横縞の目印に向かい、猫の探検家がしゃがんで観察しています。奥の和紙には離れた琥珀色と青緑色の神経風モチーフ。視覚課題と遠隔領域の機能変化を表す概念画で、実際の配線図やタンパク質分布図ではありません。
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 18/09/2026
においを受け取る脳領域に病気関連のタンパク質を作らせたマウスで、模様を見分ける成績が低下しました。視覚領域では、そのタンパク質は検出しにくいままでした。 📅 2026年9月11日公開 🔗 doi.org/10.1016/j.neures.2026.105118 #NeuroscienceResearch #Neuroscience
和室の木製T字迷路で、黒いマウスが縦縞と横縞の目印に向かい、猫の探検家がしゃがんで観察しています。奥の和紙には離れた琥珀色と青緑色の神経風モチーフ。視覚課題と遠隔領域の機能変化を表す概念画で、実際の配線図やタンパク質分布図ではありません。
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 15/09/2026
In mice after stroke, stimulating brain support cells before rehabilitation enhanced recovery of paw movement during later training. 📅 Published: Sep 13, 2026 🔗 doi.org/10.1016/j.neures.2026.105120 #NeuroscienceResearch #Neuroscience
和風の研究室で、黒いマウスが木の窓から前足を伸ばして餌を取ろうとし、猫の探検家が観察しています。別の和紙屏風にはアストロサイトを表す星形の細胞。細胞への刺激と、その後の訓練を分けた概念画で、顕微鏡像や治療効果の再現ではありません。
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 15/09/2026
脳卒中を起こしたマウスで、神経を支える細胞を先に刺激すると、その後の訓練による前足の動きの回復が大きくなりました。 📅 2026年9月13日公開 🔗 doi.org/10.1016/j.neures.2026.105120 #NeuroscienceResearch #Neuroscience
和風の研究室で、黒いマウスが木の窓から前足を伸ばして餌を取ろうとし、猫の探検家が観察しています。別の和紙屏風にはアストロサイトを表す星形の細胞。細胞への刺激と、その後の訓練を分けた概念画で、顕微鏡像や治療効果の再現ではありません。
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 14/09/2026
After fracture, persistent pain in mice involved spinal DHCR7-dependent cholesterol buildup feeding into the immune signal MCP-3 and astrocyte pathways. doi.org/10.1016/j.neures.2026.105064 #NeuroscienceResearch #Neuroscience #Pain
Japanese painterly NSR cover showing a recognizable spinal dorsal-horn cross-section; activated astrocyte-like forms around a DHCR7-cholesterol source; and MCP-3 signal flow toward a measured pain-sensitivity gate. The canonical explorer examines the sequence at three checkpoints without turning it into a human treatment pathway. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 14/09/2026
骨折後の痛みが長引くとき、脊髄では脂質代謝も変わっていました。マウスでは、コレステロール合成酵素DHCR7に依存した蓄積が起こり、免疫情報分子MCP-3とアストロサイトの信号を通じて痛みの持続を支えました。 doi.org/10.1016/j.neures.2026.105064 #NeuroscienceResearch #Neuroscience #Pain
Japanese painterly NSR cover showing a recognizable spinal dorsal-horn cross-section; activated astrocyte-like forms around a DHCR7-cholesterol source; and MCP-3 signal flow toward a measured pain-sensitivity gate. The canonical explorer examines the sequence at three checkpoints without turning it into a human treatment pathway. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 13/09/2026
In the new Igfn1iCre mouse line, many labeled bipolar cells were type-7-like during development, while adult labeling spread across a wider mix of retinal cell types. doi.org/10.1016/j.neures.2026.105067 #NeuroscienceResearch #Neuroscience #Retina
Japanese painterly NSR cover showing a recognizable layered retina; type-7-like bipolar cells reaching stratum S4; and a developmental-to-adult widening of labeled cell classes. The canonical explorer follows one bipolar cell from the outer layer to its S4 terminal and then compares ages. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 13/09/2026
網膜細胞を標識する道具は、年齢で使い勝手が変わります。Igfn1iCreマウスでは、発達期に標識された双極細胞の多くがtype-7らしい形を示しましたが、成体では多様な網膜細胞が標識されました。 doi.org/10.1016/j.neures.2026.105067 #NeuroscienceResearch #Neuroscience #Retina
Japanese painterly NSR cover showing a recognizable layered retina; type-7-like bipolar cells reaching stratum S4; and a developmental-to-adult widening of labeled cell classes. The canonical explorer follows one bipolar cell from the outer layer to its S4 terminal and then compares ages. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 11/09/2026
Proximity labeling near signal-releasing axon endings in cultured neurons found about 500 bouton-enriched proteins, including established presynaptic machinery. doi.org/10.1016/j.neures.2026.105070 #NeuroscienceResearch #Neuroscience #Proteomics
Japanese painterly NSR cover showing a recognizable axon with several presynaptic boutons; a tight proximity-labeling halo around boutons; and candidate protein groups arranged outside the axon-wide comparator. The canonical explorer collects only markers falling within the bouton-centered halo. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 11/09/2026
神経細胞が次の細胞へ信号を渡す軸索末端には、どんなタンパク質が集まる? 生きた培養神経で近くの分子に印を付けると、既知のシナプス装置を含む約500の濃縮候補が見つかりました。 doi.org/10.1016/j.neures.2026.105070 #NeuroscienceResearch #Neuroscience #Proteomics
Japanese painterly NSR cover showing a recognizable axon with several presynaptic boutons; a tight proximity-labeling halo around boutons; and candidate protein groups arranged outside the axon-wide comparator. The canonical explorer collects only markers falling within the bouton-centered halo. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 10/09/2026
Does a candidate drug for neural recovery directly touch its proposed protein target? NMR measurements of molecular contact supported binding between edonerpic maleate and CRMP2. doi.org/10.1016/j.neures.2026.105068 #NeuroscienceResearch #Neuroscience #NMR
Japanese painterly NSR cover showing one folded CRMP2 protein-like form; one small edonerpic ligand-like form near a binding surface; and NMR signal rings that attenuate without becoming a fake spectrum. The canonical explorer holds a listening trumpet near the interaction and observes the fading signal rings. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 10/09/2026
候補薬は標的タンパク質に本当に触れるのでしょうか。神経機能回復の候補薬edonerpic maleateと標的候補CRMP2を、分子の接触を調べるNMRで測ると、直接結合を支持する結果が得られました。 doi.org/10.1016/j.neures.2026.105068 #NeuroscienceResearch #Neuroscience #NMR
Japanese painterly NSR cover showing one folded CRMP2 protein-like form; one small edonerpic ligand-like form near a binding surface; and NMR signal rings that attenuate without becoming a fake spectrum. The canonical explorer holds a listening trumpet near the interaction and observes the fading signal rings. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 09/09/2026
In mouse embryos, temporarily reducing host microglia before transplantation allowed more donor cells to leave the ventricle and enter brain tissue. doi.org/10.1016/j.neures.2026.105071 #NeuroscienceResearch #Neuroscience #Microglia
Japanese painterly NSR cover showing an embryonic ventricular boundary; donor microglia-like cells on both sides of that boundary; and greater parenchymal entry after host-cell depletion. The canonical explorer watches donor cells cross the ventricular edge and marks how far they travel. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 09/09/2026
発達中の脳へ細胞を移植するとき、先に「居場所」を空けると何が変わる? 胎生マウスで宿主ミクログリアを一時的に減らすと、移植した細胞が脳室に留まらず、脳組織へ入る数が増えました。 doi.org/10.1016/j.neures.2026.105071 #NeuroscienceResearch #Neuroscience #Microglia
Japanese painterly NSR cover showing an embryonic ventricular boundary; donor microglia-like cells on both sides of that boundary; and greater parenchymal entry after host-cell depletion. The canonical explorer watches donor cells cross the ventricular edge and marks how far they travel. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 08/09/2026
In mouse hippocampal CA1, synapse-related markers followed different developmental and prenatal-valproate patterns depending on layer and dorsoventral position. doi.org/10.1016/j.neures.2026.105066 #NeuroscienceResearch #Neuroscience #Synapses
Japanese painterly NSR cover showing a recognizable layered CA1 arc; separate PSD95-like and gephyrin-like puncta concepts; and three layers arranged across four developmental time markers. The canonical explorer uses a transparent coordinate grid to compare puncta across CA1 layers. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 08/09/2026
海馬CA1の変化を平均してしまうと、層ごとの違いは消えてしまいます。マウス組織を層の座標に沿って調べると、シナプスに関わる目印の発達と、胎生期バルプロ酸曝露後の変化は場所ごとに異なりました。 doi.org/10.1016/j.neures.2026.105066 #NeuroscienceResearch #Neuroscience #Synapses
Japanese painterly NSR cover showing a recognizable layered CA1 arc; separate PSD95-like and gephyrin-like puncta concepts; and three layers arranged across four developmental time markers. The canonical explorer uses a transparent coordinate grid to compare puncta across CA1 layers. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 07/09/2026
Can structural MRI distinguish ADHD from typical development without predefined brain regions? A Vision Transformer outperformed a baseline CNN and a standard region-based method. doi.org/10.1016/j.neures.2026.105054 #NeuroscienceResearch #Neuroscience #NeuroAI
Japanese washi-style night observatory: the canonical cat explorer counts eleven simple brain-slice outline tiles while a larger slice stack and a compact rack feed an indigo patch grid. Two supported regions on a painterly brain outline glow amber and vermilion, beside a Neuroscience Research banner.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 07/09/2026
脳を決まった領域に切り分けなくても、構造MRIからADHDと定型発達を分類できる? 画像全体の関係を学ぶモデルは、基準にした画像認識AIと脳領域ごとの従来法より高い分類性能を示しました。 doi.org/10.1016/j.neures.2026.105054 #NeuroscienceResearch #Neuroscience #NeuroAI
Japanese washi-style night observatory: the canonical cat explorer counts eleven simple brain-slice outline tiles while a larger slice stack and a compact rack feed an indigo patch grid. Two supported regions on a painterly brain outline glow amber and vermilion, beside a Neuroscience Research banner.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 06/09/2026
In mice, cells expressing the adhesion molecule Pcdhβ3 showed coordinated activity across cortex and hippocampus and recruited matching cells through their projections. doi.org/10.1016/j.neures.2026.105081 #NeuroscienceResearch #Neuroscience #Memory
Japanese painterly NSR cover showing recognizable entorhinal and hippocampal regions; matching Pcdhβ3-defined cell populations; and a projection-dependent bridge that is present but not an invented full circuit. The canonical explorer compares matching cell lanterns on both sides of the projection boundary. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 06/09/2026
海馬と皮質をまたぐ神経集団は、同じ「細胞の名札」を共有するのでしょうか。マウスでは、Pcdhβ3という接着分子を持つ細胞の活動が領域間で対応し、投射を通じて同じ型の細胞が応答しました。 doi.org/10.1016/j.neures.2026.105081 #NeuroscienceResearch #Neuroscience #Memory
Japanese painterly NSR cover showing recognizable entorhinal and hippocampal regions; matching Pcdhβ3-defined cell populations; and a projection-dependent bridge that is present but not an invented full circuit. The canonical explorer compares matching cell lanterns on both sides of the projection boundary. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 05/09/2026
Social context changed how the same tutor song was represented in juvenile zebra finches: some responses in the reward-related midbrain VTA/SNc grew stronger, while others grew weaker. doi.org/10.1016/j.neures.2026.105108 #NeuroscienceResearch #Neuroscience
和風の二つの聴音座敷。左では幼いキンカチョウが一羽で、右では親鳥と並んで同じ藍色の歌の帯を聞く。中央の探検家が帯を支え、二つの提灯の背後では一方に強い橙色、もう一方に淡い白色の波が広がる。左下に「Neuroscience Research」の和紙看板。
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 05/09/2026
同じ親鳥の歌でも、隣に誰がいるかで脳の反応は変わる? 幼いキンカチョウでは、学習や報酬に関わる中脳領域VTA/SNcの歌への応答が、社会的な状況によって強まる方向にも弱まる方向にも変化しました。 doi.org/10.1016/j.neures.2026.105108 #NeuroscienceResearch #Neuroscience
和風の二つの聴音座敷。左では幼いキンカチョウが一羽で、右では親鳥と並んで同じ藍色の歌の帯を聞く。中央の探検家が帯を支え、二つの提灯の背後では一方に強い橙色、もう一方に淡い白色の波が広がる。左下に「Neuroscience Research」の和紙看板。
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 01/09/2026
Patient-derived excitatory and inhibitory neurons both showed more spontaneous calcium activity, but their drug responses and gene-expression changes diverged. doi.org/10.1016/j.neures.2026.105080 #NeuroscienceResearch #Neuroscience #Epilepsy
Japanese painterly NSR cover showing two clearly distinct excitatory and inhibitory neuron groups; repeated calcium-light pulses in both groups; and separate subtype-specific transcript scrolls. The canonical explorer observes two cell groups simultaneously and compares their pulse patterns. A small washi banner reads Neuroscience Research.
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Neuroscience Research Highlights @nsrhighlights.bsky.social · 01/09/2026
DNAの反復配列が伸びる遺伝性てんかんBAFME。患者由来の培養神経では、興奮性と抑制性の両方で自発的なカルシウム活動が増えました。一方、薬への応答と遺伝子発現は細胞型で異なりました。 doi.org/10.1016/j.neures.2026.105080 #NeuroscienceResearch #Neuroscience #Epilepsy
Japanese painterly NSR cover showing two clearly distinct excitatory and inhibitory neuron groups; repeated calcium-light pulses in both groups; and separate subtype-specific transcript scrolls. The canonical explorer observes two cell groups simultaneously and compares their pulse patterns. A small washi banner reads Neuroscience Research.
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