iiinova — where your digital self keeps evolving

Noah Olsman

@noaholsman.bsky.social

Postdoc in synthetic biology in Johan Paulsson's lab at HMS SysBio. Trying to understanding feedback circuits in living cells by building them.

Posts Replies Media

Reposted by Noah Olsman

Biocontrol Seminars @bioctrl.bsky.social · 06/07/2026

🕙 9 days until the early-bird deadline for #Biocontrol26 Thrilled to highlight one of our speakers: Dr @noaholsman.bsky.social Noah brings together control, dynamical systems, and synbio to understand how feedback shapes robustness in biomolecular circuits. biocontrolseminars.org/biocontrol26

044

Noah Olsman @noaholsman.bsky.social · 27/07/2025

This paper argued a branch of cephalopods traded genome plasticity for the ability to edit their mRNA. This branch also happens to be the smart cephalopods! They don't go as far as saying the trade-off is what made them smart, but it is definitely implied. pmc.ncbi.nlm.nih.gov/articles/PMC...

pmc.ncbi.nlm.nih.gov

Trade-off between transcriptome plasticity and genome evolution in cephalopods

RNA editing, a post-transcriptional process, allows the diversification of proteomes beyond the genomic blueprint; however it is infrequently used among animals. Recent reports suggesting increased le...

1212

Noah Olsman @noaholsman.bsky.social · 11/06/2025

Awesome new paper from our lab!

000

Noah Olsman @noaholsman.bsky.social · 26/04/2025

www.embopress.org/doi/full/10....

embopress.org

Precision design of stable genetic circuits carried in highly‐insulated E. coli genomic landing pads | Molecular Systems Biology

image image Ultra‐stable genetic circuits with customizable designs are encoded in the Escherichia coli genome by integrating genetic circuit design automation (Cello) with three highly insulated gen...

020

Noah Olsman @noaholsman.bsky.social · 26/04/2025

At least in E coli, the terminators in this paper are the best I've found anywhere and have made a pretty massive difference in read through over even other synthetic terminators.

110

Noah Olsman @noaholsman.bsky.social · 27/09/2023

The man works magic the rest of us can only dream of

110

Noah Olsman @noaholsman.bsky.social · 27/09/2023

Our lab has big news!! hms.harvard.edu/news/hms-res...

hms.harvard.edu

HMS Researcher to Lead $104 Million Federal Project Tackling Antibiotic Resistance

Effort aims to develop technology to transform diagnosis, treatment of bacterial infections

151