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Noah Fierer

@noahfierer.bsky.social
2.7K followers 209 following 114 posts

Microbial ecologist www.fiererlab.org

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Noah Fierer @noahfierer.bsky.social · 02/10/2026
A plea: If you are leading a faculty search and you expect 100s of applications - please do not request letters up front! You are basically telling your colleagues that you do not value their time.
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Noah Fierer @noahfierer.bsky.social · 18/09/2026
It is rare to find a paper that really blows my mind. This is one of those papers: www.nature.com/articles/s41...
nature.com
Self-generated hydrogel ejects bacterial cells for localized biofilm dispersion - Nature Microbiology
Bacillus subtilis biofilms locally disperse by ejecting motile cells through osmotic pressure generated by their poly-γ-glutamic acid hydrogel, a mechanism resembling that through which Cnidaria eject...
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Noah Fierer @noahfierer.bsky.social · 24/08/2026
Very nice paper! Impressive work and cool findings.
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Noah Fierer @noahfierer.bsky.social · 16/08/2026
@jeffinerca.bsky.social FYI - you can enter NZ even without your NZETA approved.
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Noah Fierer @noahfierer.bsky.social · 15/08/2026
Same. Mine is still pending. Hopefully it gets approved soon...
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Reposted by Noah Fierer
Louis Schipper @louisschipper.bsky.social · 01/08/2026
Lecturer position in soil science opportunity (equivalent to Assistant Prof. Looking forward to seeing some great applicants. elhs.fa.ap1.oraclecloud.com/hcmUI/Candid...
elhs.fa.ap1.oraclecloud.com
Lecturer in Soil Science
Take the next step in your academic career, conducting original research in soil science and contributing to teaching the next generation of scientists within the Earth and Environmental Sciences Team...
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Noah Fierer @noahfierer.bsky.social · 02/07/2026
Congratulations! I was an Erskine Fellow at UoC in 2023. Great place, great people. If you have any questions, don't hesitate to reach out. You'll have a blast.
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Noah Fierer @noahfierer.bsky.social · 23/06/2026
This study is amazing: www.biorxiv.org/content/10.6...
biorxiv.org
A representative of a ubiquitous bacterial lineage parasitically feeds on host RNA
Cellular metabolism is widely understood as an integrated network of redox reactions, energy conservation, and biosynthetic pathways. Here we show that across diverse prokaryotic lineages, loss of red...
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Noah Fierer @noahfierer.bsky.social · 19/06/2026
New preprint up: the power of protein language models - using a single gene (adenylate kinase) to predict the temperature optima of bacteria and bacterial communities from genomes or metagenomes www.biorxiv.org/content/10.6...
biorxiv.org
Predicting optimal growth temperatures of bacteria using learned structural information from a single protein
Temperature is a fundamental determinant of bacterial physiology and ecology. Optimal growth temperature (OGT) is highly variable across species, contributing to differences in where and when species ...
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Noah Fierer @noahfierer.bsky.social · 18/06/2026
Ever wanted to use metagenomic data to infer oxygen levels (or the oxygen preferences of whole bacterial communities)? We have the tool for you: journals.asm.org/eprint/9GUIR...
journals.asm.org
Predicting oxygen levels in microbial habitats using a metagenome-based approach | mSystems
Oxygen is one of the most important environmental variables affecting microbial activity and composition, but is often difficult to measure in situ. We developed a tool, OxyMetaG, that leverages diffe...
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Noah Fierer @noahfierer.bsky.social · 17/06/2026
I agree 100% about the 'data leakage' problem. I think we addressed this in the paper (Steps 3 and 7)
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Noah Fierer @noahfierer.bsky.social · 12/05/2026
Really useful paper explaining why richness/diversity metrics are rarely informative when applied to microbial community sequencing data: enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...
enviromicro-journals.onlinelibrary.wiley.com
Rethinking Alpha Diversity in Marker‐Gene Microbiome Studies: Dominance Matters More Than Richness
Marker-gene microbiome surveys systematically under-sample rare taxa, causing alpha diversity metrics to reflect dominance rather than true richness. This conceptual mismatch can lead to misleading e...
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Noah Fierer @noahfierer.bsky.social · 10/05/2026
I'm sure the company is doing interesting science and all the folks involved, including the 'soil stars', are well-meaning- but this bit of 'journalism' does not belong in a leading US newspaper (9/9)
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Noah Fierer @noahfierer.bsky.social · 10/05/2026
OK - this is just cringe: (7/9)
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Noah Fierer @noahfierer.bsky.social · 10/05/2026
The company appears to be using 'soil stars' (their term) to promote the company. These are all great scientists, but where are the agronomists? h/t @agronomistag.bsky.social (6/9)
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Noah Fierer @noahfierer.bsky.social · 10/05/2026
I know every company is trying to hop on the AI hype train. Maybe AI could be useful here, but I doubt it. This just seems more like marketing copy than journalism (5/9)
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Noah Fierer @noahfierer.bsky.social · 10/05/2026
Is this just snake oil being sold by well-funded salesmen? I don't know, but if the soil microbial inoculant industry has taught me anything over the years, it is to maintain a high degree of skepticism (4/9)
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Noah Fierer @noahfierer.bsky.social · 10/05/2026
The article is essentially unpaid advertising touting their microbial inoculants (see text). I realize this is not a science article, but big claims require big evidence. Same goes for their website (www.oathsoillife.com/pages/scienc...) - inoculants led to a 50% increase in SOC??? (3/9)
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Noah Fierer @noahfierer.bsky.social · 10/05/2026
First, the article appears to be a blatant attempt to restore the reputation of the company's billionaire founder (and convicted felon). Using 'journalism' for reputation laundering is not new, but it is still cringe-worthy (2/9)
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Noah Fierer @noahfierer.bsky.social · 10/05/2026
The recent NY Times article on Oath (a soil inoculant company) warrants a mini-thread, so here we go: www.nytimes.com/2026/05/01/b... (1/9)
nytimes.com
After Prison, a Financial Titan Plots an Unlikely Comeback
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Noah Fierer @noahfierer.bsky.social · 06/05/2026
New pre-print out - we sought to determine if Antarctic soil bacteria are really endemic to the continent. Would love feedback. www.biorxiv.org/content/10.6...
biorxiv.org
Evidence for endemism and local adaptation in Antarctic soil bacteria
Antarctic soils represent one of the more extreme environments for microbial life on Earth, yet they harbor heterogeneous and diverse microbial communities. Biologists have long hypothesized that Antarctic microorganisms are unique from those found on other continents due to the extreme geographic isolation and the cold, dry, and challenging conditions typical of Antarctica. To test this hypothesis, we focused on a cosmopolitan bacterial genus, Arthrobacter, that is widely distributed across global soils. We first profiled a global metagenomic dataset from both Antarctic and non-Antarctic surface soils to quantify the distributions of Arthrobacter strains. Despite high strain-level diversity, 90% of the strains found in the Antarctic soils were only found on the continent. We then used cultivation-based phenotypic analyses and strain-level genomic comparisons to assess how Antarctic strains and non-Antarctic strains differ in their traits and environmental preferences. Not only did we find evidence of endemism, but Antarctic Arthrobacter also have genomic characteristics and environmental tolerances that suggest they are uniquely adapted to Antarctic conditions. ### Competing Interest Statement The authors have declared no competing interest. U.S. National Science Foundation, NSF 21-567, EAR 1950681 Australian Research Council, FT240100502, DE250101210
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Noah Fierer @noahfierer.bsky.social · 21/04/2026
I was excited to read this paper until I got to this section describing their Methods. Big claims require better evidence. www.pnas.org/doi/10.1073/...
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Noah Fierer @noahfierer.bsky.social · 31/03/2026
Another day of microbiome scientists jumping the shark
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Noah Fierer @noahfierer.bsky.social · 27/01/2026
If you haven't yet, check out Sylph - very useful tool (but I don't know how well it would work for your particular analyses): www.nature.com/articles/s41...
nature.com
Rapid species-level metagenome profiling and containment estimation with sylph - Nature Biotechnology
The microbial composition of metagenomes is identified in seconds by profiling against large databases.
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Noah Fierer @noahfierer.bsky.social · 26/01/2026
Looking for a tool to estimate abundances of aerobes versus anaerobes directly from metagenomes? Here you go: www.biorxiv.org/content/10.6...
biorxiv.org
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Noah Fierer @noahfierer.bsky.social · 14/01/2026
Please do send along any questions/comments that emerge from the discussion. You could also invite the lead author to join
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Noah Fierer @noahfierer.bsky.social · 08/01/2026
New preprint up on airborne fungi across the US with a focus on fungal allergens - would love feedback. www.biorxiv.org/content/10.6...
biorxiv.org
Spatiotemporal dynamics in airborne fungi and fungal allergens across the United States
A broad diversity of fungi can be found in the near-surface atmosphere, with both the amounts and types of airborne fungi varying across space and time. However, the specific spatiotemporal patterns i...
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Noah Fierer @noahfierer.bsky.social · 08/01/2026
Feel free to shoot the lead author (Hoffert) an email - he can share the hi-res version. Hopefully the final version for publication will be higher resolution.....
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Noah Fierer @noahfierer.bsky.social · 06/01/2026
New paper up - inspired by the periodic table of the elements, we attempted to organize bacterial diversity in genome-inferred trait space academic.oup.com/ismej/advanc...
academic.oup.com
Constructing a “periodic table” of bacteria to map diversity in trait space
Abstract. Despite an ever-expanding number of bacterial taxa being discovered, many of these taxa remain uncharacterized with unknown traits and environmen
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Noah Fierer @noahfierer.bsky.social · 08/12/2025
New paper out looking at mycobacterial diversity across soils, premise plumbing, and surface waters to try to figure out the source of environmentally-acquired mycobacterial infections: journals.asm.org/doi/epdf/10....
journals.asm.org
A cross-environment comparison of nontuberculous mycobacterial diversity
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Noah Fierer @noahfierer.bsky.social · 10/10/2025
New paper out demonstrating how we can use strain-level analyses of soil metagenomes to investigate the biogeographical patterns exhibited by a dominant group of soil bacteria (Bradyrhizobium) academic.oup.com/ismej/advanc...
academic.oup.com
Validate User
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Noah Fierer @noahfierer.bsky.social · 06/08/2025
New preprint led by Matt Gebert focused on the environmental reservoirs of nontuberculous mycobacterial (NTM) pathogens. NTM disease is environmentally acquired, but routes of exposure unclear. Our work implicates premise plumbing as the main culprit! www.biorxiv.org/content/10.1...
biorxiv.org
A cross-environment comparison of nontuberculous mycobacterial diversity
Nontuberculous mycobacteria (NTM) are a group of environmental bacteria that encompass nearly 200 described species, some of which can cause chronic pulmonary infection in humans. What makes these inf...
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Noah Fierer @noahfierer.bsky.social · 28/07/2025
After 15 years, the authors of the infamous 'arsenic life' paper are still trying to argue that their findings are legit and not just a product of 'major errors'? Unbelievable. The authors' response to the retraction is infuriating. Time to let it go. www.science.org/doi/10.1126/...
science.org
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Noah Fierer @noahfierer.bsky.social · 18/07/2025
We hope the approach and our draft 'periodic table' are useful and encourage future efforts to systematically characterize trait variance across the bacterial tree of life.(6/6)
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Noah Fierer @noahfierer.bsky.social · 18/07/2025
Perhaps more importantly, the workflow for generating the 'periodic table' is adaptable so it can ultimately be expanded to incorporate additional traits/taxa (5/6).
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Noah Fierer @noahfierer.bsky.social · 18/07/2025
Our draft 'periodic table' of bacterial diversity, like the periodic table of the elements, provides a interpretable & concise way to visualize and explore bacterial diversity in trait space (see Figs 4-5) - linking phylogeny to trait distributions in a quantifiable manner (4/6)
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Noah Fierer @noahfierer.bsky.social · 18/07/2025
Here we focused on 6 traits - inferring those traits (including autotrophy, O2 tolerance, phototrophy, etc.) using genome-based models across >50,000 bacterial 'species' (thanks @ace-gtdb.bsky.social!) (3/6)
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Noah Fierer @noahfierer.bsky.social · 18/07/2025
Work was motivated by the challenges associated with linking taxonomic/phylogenetic information to knowledge of what we know (or think we know) about bacterial traits (2/6)
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Noah Fierer @noahfierer.bsky.social · 18/07/2025
New pre-print from my group - project led by PhD student Michael Hoffert. We set out on a daunting mission to generate a 'periodic table' of bacterial diversity (1/6) www.biorxiv.org/content/10.1...
biorxiv.org
A periodic table of bacteria?: Mapping bacterial diversity in trait space
Bacterial diversity can be overwhelming. There is an ever-expanding number of bacterial taxa being discovered, but many of these taxa remain uncharacterized with unknown traits and environmental prefe...
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Noah Fierer @noahfierer.bsky.social · 14/07/2025
I agree with both of these papers. Given that they were published >10 years ago, why is the 'hologenome' concept still a thing?
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Noah Fierer @noahfierer.bsky.social · 25/06/2025
See Table 1 of this paper: bmcbiol.biomedcentral.com/articles/10....
bmcbiol.biomedcentral.com
Reagent and laboratory contamination can critically impact sequence-based microbiome analyses - BMC Biology
Background The study of microbial communities has been revolutionised in recent years by the widespread adoption of culture independent analytical techniques such as 16S rRNA gene sequencing and metag...
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Noah Fierer @noahfierer.bsky.social · 24/06/2025
Correct - if you filtered a few liters of your saliva for DNA extraction, you would undoubtedly have far far higher DNA yields than a few liters of household water
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Noah Fierer @noahfierer.bsky.social · 21/06/2025
Hope this is useful - consensus statement "Guidelines for preventing and reporting contamination in low-biomass microbiome studies" rdcu.be/er3Io
rdcu.be
Guidelines for preventing and reporting contamination in low-biomass microbiome studies
Nature Microbiology - In this Consensus Statement, the authors outline strategies for processing, analysing and interpreting low-biomass microbiome samples, and provide recommendations to minimize...
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Noah Fierer @noahfierer.bsky.social · 30/05/2025
New study out - we developed a pipeline for targeted assembly of genomes from (complex) soil metagenomes to examine the strain-level diversity and ecology of a dominant soil bacterial genus (Bradyrhizobium). Feedback appreciated. www.biorxiv.org/content/10.1...
biorxiv.org
Continent-wide assessment of the strain-level diversity of Bradyrhizobium, a dominant soil bacterial genus
Global surveys of soil bacteria have identified several taxa that are nearly ubiquitous and often the most abundant members of soil bacterial communities. However, it remains unclear why these taxa ar...
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Noah Fierer @noahfierer.bsky.social · 21/05/2025
This is cool - bacteria wrap their flagella to propel themselves through narrow passages www.biorxiv.org/content/10.1...
biorxiv.org
Bacteria break through one-micrometer-square passages by flagellar wrapping
Confined spaces are omnipresent in the micro-environments, including soil aggregates and intestinal crypts, yet little is known about how bacteria behave under such conditions where movement is challe...
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Noah Fierer @noahfierer.bsky.social · 08/05/2025
Just your regular reminder that 'sterile' doesn't mean 'DNA-free'! (this rant brought to you by yet another published DNA-based study conducted in a low biomass system where appropriate controls do not appear to have been included)
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Noah Fierer @noahfierer.bsky.social · 07/05/2025
Excellent work (and very well-written)
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Noah Fierer @noahfierer.bsky.social · 07/05/2025
Dear fellow olds - recognize that the term 'next generation sequencing' is confusing to those that never had experience with the first generation. Also - what 'generation' are we on anyways?
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Noah Fierer @noahfierer.bsky.social · 01/05/2025
This looks awesome. Open to PhD students from the US?
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Noah Fierer @noahfierer.bsky.social · 29/04/2025
👆 Yes. 100% agreed.
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