Median OS was 28 months (95% CI, 13-NR) in arm 1, 37 months (95% CI, 26-NR) in arm 2, and 68 months (95% CI, 38-NR) in arm 3.

A Northwestern Medicine study published in the Journal of Clinical Investigation has uncovered a connection between a well-known cancer-related protein and a major RNA modification process, which may ...

Regarding acceptable risk thresholds, Alam describes himself as relatively risk-averse, favoring a 5% to 10% miss rate for Grade Group 2 or higher disease when considering biopsy avoidance.

Making the Move: Early and Mid-Career Job Changes Guest: Patrick Selph, MD Host: Jennifer Miles-Thomas, MD, MBA, URPS Career paths in urology are not one-size fits all. Join us as Dr. Patrick Selph,...

YouTube video by Breakthroughs for Physicians

Alam frames PHI and MRI as noninvasive tools that help refine risk before proceeding to biopsy.

YouTube video by Breakthroughs for Physicians

Ridwan I. Alam, MD, MPH, shares results from a recent study evaluating the Prostate Health Index test in men with PSA levels between 10 and 20 ng/mL.

Urologist Jennifer Miles-Thomas, MD, URPS, MBA, discusses the trend of academic centers moving into communities outside of big cities.

After unsuccessful vasectomy reversal and IVF attempts, a 47-year-old patient achieved healthy semen results following bilateral epididymovasostomy performed by Dr. Robert Brannigan.

Introduction Transplantation in patients with active malignancies is controversial due to concerns about immunosuppression accelerating cancer progression and ethical allocation of donor organs. Pro...

Through genomic and transcriptomic profiling, investigators identify four NMIBC subtypes and show that inflamed tumors have superior BCG response and lower recurrence risk.

High-risk bladder cancer recurs in 30% of cases and causes fatal outcomes in 10% within 2 yr despite surgical resection, endoscopic surveillance, and …

Amy Krambeck, MD, explores imaging options for kidney stones during pregnancy, emphasizing transvaginal ultrasound as a safe, radiation-free tool.

Joshua J. Meeks, MD, PhD, discussed the emerging role of ctDNA in guiding adjuvant and neoadjuvant strategies in patients with bladder cancer.

Panelists discuss new findings on adjuvant immunotherapy for high-risk bladder cancer revealing significant insights into patient outcomes and treatment strategies.

The Northwestern Medicine Gay and Bisexual Men’s Urology Program is designed to deliver better urologic care for patients who were assigned male at birth and identify as gay or bisexual.

Several experts share their thoughts on the impact of the gemcitabine intravesical system for BCG-unresponsive NMIBC.

AS-eligible patients with APF at RP demonstrate differences in gene expression when compared to those without APF. We established that multiple existing genomic classifiers not previously studied in t...

Krambeck pointed to the growing importance of medical management in stone disease prevention.

Dr. Ziho Lee tackles a challenging vesicourethral anastomotic stricture, using a dual robotic-perineal approach to restore function in a post-prostatectomy patient.

Introduction and Objectives: Managing nephrolithiasis during pregnancy requires collaboration between obstetricians and urologists. When surgical intervention is needed, ureteroscopy (URS) is a safe and effective; however, limited data exist on obstetric (OB) management and complications of URS during pregnancy. This multicenter study aimed to clarify OB practice patterns and complications of URS in pregnant patients. Methods: A multicenter retrospective review of pregnant patients who underwent URS with fellowship-trained endourologists at seven institutions from 2015 to 2024 was performed. We recorded patient demographics, indications for URS, preoperative workup, intraoperative details, perioperative OB involvement, fetal monitoring (FM) practices, and postoperative OB complications within 30 days. Results: We identified 72 cases of URS during pregnancy. Mean maternal age was 30 years, and mean gestational age was 23.5 weeks. Preoperative imaging was performed in all cases, with ultrasound used in 70/72 (97%). No intraoperative complications were noted. OB involvement and FM varied among institutions—one site required perioperative OB presence with FM, five sites performed FM case-by-case, and one site required pre- and postoperative nonstress tests (NST). FM was done in 11/72 cases, while intraoperative FM was performed in 16/72 cases. OB was present in 13/72 cases. OB complications occurred in eight cases. There were no cases of preterm labor in the immediate perioperative; however, three cases had postoperative admissions with spontaneously resolving contractions and abnormal NST. The two cases of preterm labor requiring C-section at 27 weeks were linked to OB comorbidities. Conclusions: URS is safe in pregnancy in the care of urologists who are experienced in stone disease. OB management and FM during URS are heterogeneous across institutions. In this multicenter series, there were no cases of preterm labor. Cases of early contractions and abnormal NST resolved spontaneously. Standardization of OB practice patterns during URS could be beneficial and incorporated in further guideline development.