Reposted by @nishitgoradia.bsky.social
We are delighted to share a stunning short/long chain acyl-CoA carboxylase complex with a total of 16 subunits (8 x AccA3, 2 x AccD4, 4 x AccD5, 2 x AccE5). It hosts two related carboxylate transferase subunits (AccD4, AccD5). Our story is now on www.biorxiv.org/content/10.1101/2025.11.15.688623v1
biorxiv.org
Architecture of an asymmetric mycobacterial short chain/long chain acyl-CoA carboxylase
Endogenous extraction has revealed a mycobacterial hybrid acyl-CoA carboxylase (ACCase) complex exhibiting distinct long-chain (LC) and short-chain (LC) acyl-CoA carboxyl transferase (CT) activities. ...