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The Nirmal Lab (Harvard + MGB)

@nirmallab.com

Imagine understanding cancer on a neighborhood level—not just cell by cell. In our lab, we’re combining spatial biology and AI to study cancer in ways that could redefine precision medicine. What excites you about AI in healthcare? Let’s discuss!

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The Nirmal Lab (Harvard + MGB) @nirmallab.com · 13/12/2024

Had a wonderful time at our department Christmas party! @ermakov-mikhail.bsky.social @tylerjost.bsky.social @ajitjohnson.com

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The Nirmal Lab (Harvard + MGB) @nirmallab.com · 21/11/2024

🚀✨Exciting update for #scimap users!🚀 We've supercharged #visualgating with: 🖼️ Memory optimization for huge images 🔗 Seamless Napari component linking ⏱️ Fewer clicks = faster, smoother gating Get ready for a speed boost to your workflows! ⚡🙌 scimap.xyz/Functions/pl... #imaging #spatialbiology 🧪

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The Nirmal Lab (Harvard + MGB) @nirmallab.com · 19/11/2024

They show that CTCL tumor cells are spatially associated with B cells, forming tertiary lymphoid structure-like aggregates and validated the enrichment of B cells and its association with disease progression across three independent patient cohorts.

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The Nirmal Lab (Harvard + MGB) @nirmallab.com · 19/11/2024

Atlas of Cutaneous T Cell Lymphoma Unveils Malignant TH2 Cells Sustained by a B Cell-Enriched Tumor Microenvironment 🧪 idp.nature.com/authorize?re...

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The Nirmal Lab (Harvard + MGB) @nirmallab.com · 18/11/2024

The HDR approach dramatically improves accuracy in PD-L1 evaluation and enables 3D spatial analysis of tumor tissues—a step towards more precise pathology! www.nature.com/articles/s41...

nature.com

Optimizing immunofluorescence with high-dynamic-range imaging to enhance PD-L1 expression evaluation for 3D pathology assessment from NSCLC tumor tissue - Scientific Reports

Scientific Reports - Optimizing immunofluorescence with high-dynamic-range imaging to enhance PD-L1 expression evaluation for 3D pathology assessment from NSCLC tumor tissue

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The Nirmal Lab (Harvard + MGB) @nirmallab.com · 18/11/2024

PDL1 is generally very weak and heterogeneous, making it difficult to image (given its importance clinically). Huang et al. optimized a high-dynamic-range (HDR) imaging method for immunofluorescence to assess PD-L1 expression. 🧪

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The Nirmal Lab (Harvard + MGB) @nirmallab.com · 18/11/2024

Would love to join as well.

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The Nirmal Lab (Harvard + MGB) @nirmallab.com · 17/11/2024

A fascinating tool linking embryonic growth to molecular signals. www.cell.com/cell/fulltex...

cell.com

Spatiotemporal modeling of molecular holograms

Spateo is a comprehensive framework for 3D reconstruction and characterization of spatial gradients and cellular interactions at whole-organ and embryo levels, using spatial transcriptomics. Important...

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The Nirmal Lab (Harvard + MGB) @nirmallab.com · 17/11/2024

Great work by Qiu et al.—Spateo builds detailed 3D models of mouse embryos, capturing spatial dynamics and cell interactions. They use morphometric vector fields to reveal the molecular drivers of asymmetric heart development. 🧪

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Reposted by The Nirmal Lab (Harvard + MGB)

Ajit Johnson Nirmal @ajitjohnson.com · 17/11/2024

Let’s create a community for #spatialbiology - Let’s add to this list. go.bsky.app/AE8csH9

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