Aberrant aggregation of the prion-like RNA binding protein TDP-43 drives several fatal neurodegenerative proteinopathies, including amyotrophic lateral sclerosis (ALS). In this work, we define how sho...

To address the limitation that prevailing cross-domain Parkinson's disease (PD) speech recognition methods mitigate small-sample issues via distribution matching while disregarding substantial feature

Insight into the Neuroprotective Mechanisms of Resveratrol: Inhibition of Alpha-Synuclein Fibrillation and its Role in Mitigating Toxicity

Alzheimer's disease and Parkinson's disease are the two most prevalent neurodegenerative disorders worldwide, both characterized by progressive neuronal loss. Despite distinct pathophysiological featu

<span><i>Objective</i>: Bulbar dysfunction often diminishes the accuracy and speed of the tongue, lip, and jaw movements necessary for speech production. Vowel acoustic features derived from speech re

The goal of this study was to investigate the effectiveness of haptic resistive force feedback in improving the upper limb tremors in Parkinson's Disease (PD) during a button push task. We developed a

This study investigated the large-scale dynamic brain network mechanisms underlying cognitive decline in Parkinson's disease (PD) by integrating high-density Electroencephalography (EEG) signal source

To estimate the overall survival rate, disease stage, age of people with Parkinson's disease, and time since diagnosis and in relation to physical exercise. Retrospective-prospective longitudinal obse

Synaptic loss is an early hallmark of Alzheimer's disease (AD), predominantly driven by aberrant microglial reactivity. Pioglitazone, a peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist wi

Treatment burden is common amongst PwP and caregivers and could be identified in clinical practice using the MTBQ. There is a need for change at individual provider and system levels to recognise and

Serum amyloid A (SAA) is the principal precursor of AA amyloidosis, yet the early molecular steps that trigger its pathological misfolding remain unclear. Here, we combine harmonic linear discriminant

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by dopaminergic neuron loss and α-synuclein aggregation. Dental pulp stem cells (DPSCs) have emerged as a promising t

The period from tafamidis discontinuation to death was shorter in ATTRwt-CM patients hospitalized for non-cardiovascular diseases. Discussions of the right period for discontinuation are needed.

Of the many ways that speech can be objectified, pauses appear particularly important for understanding cognition in AD. Pause analysis has the benefit of being face valid, interpretable in ratio form