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Nautilus Biotechnology @nautilus.bio · 01/10/2026

Our new blog post walks through how you can measure AKT1 or EGFR proteoforms at no charge through the Iterative Mapping Grant Program – Oncology. 🔵 3 awardees. 🔵 12 samples each. 🔵 Applications close November 6. Read more & apply: www.nautilus.bio/blog/announc... #Proteoforms #CancerResearch

nautilus.bio

Announcing the Iterative Mapping Grant Program – Oncology: AKT1 and EGFR proteoform analysis at no charge

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Nautilus Biotechnology @nautilus.bio · 30/09/2026

And if you'd like to incorporate the Nautilus Tau Proteoforms Assay into your workflows, join the Iterative Mapping Early Access Program: www.nautilus.bio/nautiluseap/ Next up is #ASHG2026 - we hope to see you in Montréal!

nautilus.bio

Nautilus Iterative Mapping Early Access Program

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Nautilus Biotechnology @nautilus.bio · 30/09/2026

If you'd like to use the Nautilus Voyager™ Platform to explore AKT1 or EGFR proteoforms, be sure to apply to the Iterative Mapping Grant Program by November 6th: www.nautilus.bio/iterative-ma...

nautilus.bio

Iterative Mapping Grant Program ~ Nautilus Biotechnology

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Nautilus Biotechnology @nautilus.bio · 30/09/2026

That's a wrap for #HUPO2026! Thank you to everyone who came to our booth, posters, and panel on the potential for proteoforms to change our understanding of biology. And a very special thanks to panelists Birgit Schilling, Bernd Wollscheid, and Jochen Schwenk! We'll share the recording soon.

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Nautilus Biotechnology @nautilus.bio · 29/09/2026

During the webinar, Sheri Wilcox, PhD, will also invite you to apply to the Iterative Mapping Grant Program for your chance to analyze 12 samples with the AKT1 or EGFR Proteoforms Assays at no charge. www.nautilus.bio/iterative-ma...

nautilus.bio

Iterative Mapping Grant Program ~ Nautilus Biotechnology

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Nautilus Biotechnology @nautilus.bio · 29/09/2026

Register for our upcoming webinar (Oct 6, 2026, 08:00 AM PDT) to hear directly from Taylor Bertucci, Principal Investigator at the Neural Stem Cell Institute, who's using the Nautilus Voyager™ Platform to investigate tau proteoforms in neurodegeneration. www.labroots.com/webinar/high...

Proteins immobilized on the Nautilus Voyager Platform with images evocative of functional biology such as the vitruvian man, differentiation pathways, and protein structures below them.

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Nautilus Biotechnology @nautilus.bio · 28/09/2026

Drop by booth 228 at #HUPO2026 to explore a virtual model of the Nautilus Voyager™ Platform and discover how you can incorporate our AKT1 or EGFR proteoforms assays in your research free of charge through the Iterative Mapping Grant Program: www.nautilus.bio/iterative-ma...

nautilus.bio

Iterative Mapping Grant Program ~ Nautilus Biotechnology

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Nautilus Biotechnology @nautilus.bio · 25/09/2026

🗓️ Monday, September 28 (Continued) ▶️ 1:15 pm | Poster - PS01.105 - Tau Proteoform Characterization in Patient-Derived Organoids with the IVS10 + 16 Mutation 🗓️ Tuesday, September 29 ▶️ 1:15 pm | Poster PS02.127 - Advancing Proteomics Through Iterative Mapping

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Nautilus Biotechnology @nautilus.bio · 25/09/2026

Additional Nautilus activities at HUPO 2026: 🗓️ Monday, September 28 ▶️ 12:15 pm | Panel discussion in rooms 334-336 - Can proteoforms change our understanding of biology? ▶️ 1:15 pm | Poster - PS01.146 - Single-molecule proteome profiling of oncogenic signaling proteins from cell lysates

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Nautilus Biotechnology @nautilus.bio · 25/09/2026

#HUPO2026 starts Sunday in Singapore! Find us throughout the conference at booth 228 where we'll share how the Nautilus Voyager™ Platform is designed to enable you to achieve single-molecule precision and functional clarity in proteomics. nautilus-21430832.hs-sites-na2.com/meet-with-na...

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Nautilus Biotechnology @nautilus.bio · 18/09/2026

If you'd like to use the Nautilus Tau Proteoforms Assay in your research, be sure to submit a project idea through the Iterative Mapping Early Access Program: www.nautilus.bio/nautilusEAP/

nautilus.bio

Nautilus Iterative Mapping Early Access Program

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Nautilus Biotechnology @nautilus.bio · 18/09/2026

Many thanks to Alzforum for this in-depth and thoughtful article covering our Nature Methods paper, "Large-scale single-molecule analysis of tau proteoforms." www.alzforum.org/news/researc...

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Nautilus Biotechnology @nautilus.bio · 17/09/2026

When we began using the Voyager™ Platform to investigate tau proteoforms, Parag Mallick was worried; it was entirely possible that that the status quo of investigating single modifications was enough. The reality was far more interesting and exciting. Learn why: www.nautilus.bio/blog/tau-pro...

nautilus.bio

Tau proteoform analysis – Key takeaways from our recent Nature Methods publication

Parag Mallick and Andreas Huhmer discuss "Large-scale single-molecule analysis of tau proteoforms" on Translating Proteomics.

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Nautilus Biotechnology @nautilus.bio · 15/09/2026

Do you have questions about proteoforms and proteoform biology? Submit them through the link below, and we may put them to our panel at #HUPO2026. nautilus-21430832.hs-sites-na2.com/submit-your-...

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Nautilus Biotechnology @nautilus.bio · 14/09/2026

To see just how powerful the platform is, please read our recent Nature Methods paper where we use the platform to quantitatively map tau proteoforms in model systems and samples from donors with and without Alzheimer's disease: www.nature.com/articles/s41...

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Nautilus Biotechnology @nautilus.bio · 14/09/2026

We're proud to share that we received an honorable mention in the Fast Company 2026 Innovation by Design Awards for our work developing the Nautilus Voyager™ Platform and demonstrating its potential to drive research into a wide range of diseases. www.fastcompany.com/91590003/gen... #fcdesignawards

fastcompany.com

26 projects that exemplify excellence in design

See all the honorees of Fast Company’s 2026 Innovation by Design Awards in the general excellence category.

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Nautilus Biotechnology @nautilus.bio · 14/09/2026

If you'd like to access the supercut of all the videos from this series, please fill out the form here: nautilus-21430832.hs-sites-na2.com/large-scale-...

nautilus-21430832.hs-sites-na2.com

Large-scale single-molecule analysis of tau proteoforms video

Access the full video by filling out the form here.

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Nautilus Biotechnology @nautilus.bio · 14/09/2026

Some key takeaways: 🔵 Today's phospho-tau biomarkers are measured in ways that miss most of the information. 🔵 Profiling patient brains revealed distinct, disease-associated tau proteoform signatures. 🔵 The data suggests tau phosphorylation follows a preferred order.

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Nautilus Biotechnology @nautilus.bio · 14/09/2026

Published today! The last video in our new series covering our Nature Methods paper, "Large-scale single-molecule analysis of tau proteoforms." In it, James Joly covers the use of Iterative Mapping to measure tau proteoform profiles in patients with and without dementia. youtu.be/BBn45HwFuyw?...

youtu.be

Large-scale single-molecule analysis of tau proteoforms - Figure 5 with James Joly

YouTube video by Nautilus Biotechnology

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Nautilus Biotechnology @nautilus.bio · 11/09/2026

Check back in on Monday for the final video in the series. In it, James Joly shares how the assay was used to quantify tau proteoforms in samples from people with and without Alzheimer's disease.

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Nautilus Biotechnology @nautilus.bio · 11/09/2026

In today's new video in our series covering our Nature Methods paper, Vivekananda Budamagunta walks you through figure 4 where the assay is used to characterize the tau proteoform landscapes found in model systems of neurodegenerative disease. Learn more: youtu.be/wCH5Yl3nd-g?...

youtu.be

Large-scale single-molecule analysis of tau proteoforms - Figure 1 with Vivek Budamagunta

YouTube video by Nautilus Biotechnology

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Nautilus Biotechnology @nautilus.bio · 11/09/2026

🔵 Title: High-resolutional functional biology - linking proteoforms and disease 🗣️ Speakers: Sheri Wilcox, Ph.D., Nautilus VP of Scientific Engagement & Taylor Bertucci, Ph.D., Principal Inviestigator at the Neural Stem Cell Institute 🗓️ Date: Tuesday, October 6th, 2026 🕗 Time: 8:00 am PT

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Nautilus Biotechnology @nautilus.bio · 11/09/2026

Want to learn more about the applications of the Tau Proteoforms Assay described in our recent Nature Methods paper? Register for our webinar featuring Taylor Bertucci from the Regenerative Research Foundation/Neural Stem Cell Institute: www.labroots.com/webinar/high...

labroots.com

High-resolution functional biology - linking proteoforms and disease

Taylor Bertucci Ph.D., Principal Investigator at the Neural Stem Cell Institute joins Nautilus VP of Scientific Engagement, Sheri Wilcox Ph.D., to share how the Nautilus Voyager™ Platf

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Nautilus Biotechnology @nautilus.bio · 10/09/2026

In the latest video in our series covering our recent Nature Methods paper, "Large-scale single-molecule analysis of tau proteoforms," Maryam Jouzi walks you through figure 3. This figures quantifies the accuracy, reproducibility, and dynamic range of the Tau Proteoforms Assay. youtu.be/a3r0CpflOr0

youtu.be

Large-scale single-molecule analysis of tau proteoforms - Figure 3 with Maryam Jouzi

YouTube video by Nautilus Biotechnology

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Nautilus Biotechnology @nautilus.bio · 09/09/2026

We'll share the takeaways from the panel after the conference and discuss additional questions on a future episode of Translating Proteomics.

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Nautilus Biotechnology @nautilus.bio · 09/09/2026

Do you have questions about proteoforms? At #HUPO2026, we're convening a panel of experts to discuss whether proteoforms can change our understanding of biology. Submit your questions for the panel here: nautilus-21430832.hs-sites-na2.com/submit-your-...

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Nautilus Biotechnology @nautilus.bio · 09/09/2026

In the third video in our series exploring the figures from our recent Nature Methods paper, "Large-scale single-molecule analysis of tau proteoforms," Brittany Nortman covers figure 2: Application of Iterative Mapping to measure proteoforms of tau. youtu.be/mcB1-SuZLNs?...

youtu.be

Large-scale single-molecule analysis of tau proteoforms - Figure 2 with Brittany Nortman

YouTube video by Nautilus Biotechnology

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Nautilus Biotechnology @nautilus.bio · 08/09/2026

In this second video (released today), Zhengjian Zhang, Ph.D. walks you through the process for extracting and analyzing tau proteoforms on the Nautilus Voyager™ Platform. Want to see the full series now? Access it here: nautilus-21430832.hs-sites-na2.com/large-scale-...

nautilus-21430832.hs-sites-na2.com

Large-scale single-molecule analysis of tau proteoforms video

Access the full video by filling out the form here.

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Nautilus Biotechnology @nautilus.bio · 08/09/2026

ICYMI - We've launched a new video series wherein the first authors from our Nature Methods paper, "Large-scale single-molecule analysis of tau proteoforms," walk you through each of the figures from the paper and their key takeaways. www.nautilus.bio/blog/large-s...

nautilus.bio

Large-scale single-molecule analysis of tau proteoforms – Figure 1 with Zhengjian Zhang ~ Nautilus Biotechnology

Zhengjian Zhang presents Figure 1 from our recent Nature Methods paper titled, "Large-scale single-molecule analysis of tau proteoforms."

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Nautilus Biotechnology @nautilus.bio · 04/09/2026

This publication represents a strong validation of the power and potential of Iterative Mapping, but we are excited to see how YOU use Iterative Mapping and the Nautilus Voyager™ Platform to explore novel biology and achieve never-before-possible insights. www.nautilus.bio/nautiluseap/

nautilus.bio

Nautilus Iterative Mapping Early Access Program

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Nautilus Biotechnology @nautilus.bio · 04/09/2026

They each worked tirelessly on this paper and went above and beyond to join Parag Mallick in a video series further describing the paper and its findings. Access the video series: www.nautilus.bio/blog/just-pu...

nautilus.bio

Just published in Nature Methods - Large-scale single-molecule analysis of tau proteoforms

Watch our new video series for insights from the large-scale single-molecule analysis of proteoforms.

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Nautilus Biotechnology @nautilus.bio · 04/09/2026

From the Nautilus team, we’d particularly like to thank the co-first authors: James Joly, Vivek Budgamagunta, Zhengjian Zhang, Brittany Nortman, and Maryam Jouzi.

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Nautilus Biotechnology @nautilus.bio · 04/09/2026

Your expertise, deep understanding of tau and neurodegenerative disease, and innovative spirits made this work a powerful demonstration of the potential of Iterative Mapping.

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Nautilus Biotechnology @nautilus.bio · 04/09/2026

Researchers from Genentech: David Arnott, Joanna Lipka, Nikhil J Pandya, Lionel Rougé, TJ Wendroff, Don Kirkpatrick, and Alexis Rohou

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Nautilus Biotechnology @nautilus.bio · 04/09/2026

Researchers from The Ronald Loeb Center for Alzheimer’s Disease Research at Mt. Sinai: Joel Blanchard, Ana Forton-Juarez, Emily Sartori, and Jessica Schwarz

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Nautilus Biotechnology @nautilus.bio · 04/09/2026

Researchers from Genentech: David Arnott, Joanna Lipka, Nikhil J Pandya, Lionel Rougé, TJ Wendroff, Don Kirkpatrick, and Alexis Rohou

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Nautilus Biotechnology @nautilus.bio · 04/09/2026

Researchers from the Neural Stem Cell Institute: Sally Temple, Taylor Bertucci, David Butler, and Steven Lotz

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Nautilus Biotechnology @nautilus.bio · 04/09/2026

Congratulations to everyone at Nautilus and beyond who made this groundbreaking work possible! We’d particularly like to recognize our amazing collaborators including:

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Nautilus Biotechnology @nautilus.bio · 04/09/2026

🔵 Preliminary evidence suggests there are ordered pathways underlying the creation of tau proteoforms (they are not created randomly). This implies researchers may be able to prevent the generation of pathological tau proteoforms by disrupting these pathways!

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Nautilus Biotechnology @nautilus.bio · 04/09/2026

🔵 In a small cohort, tau proteoform analysis differentiates samples donated by cognitively normal individuals from those donated by people with Alzheimer’s disease and related dementias.

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Nautilus Biotechnology @nautilus.bio · 04/09/2026

🔵 Model systems commonly used in neurodegenerative disease research have distinct tau proteoform profiles.

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Nautilus Biotechnology @nautilus.bio · 04/09/2026

🔵 Iterative Mapping precisely, sensitively, and accurately quantifies tau proteoforms over a wide dynamic range with high reproducibility (≤5.5% median CV).

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Nautilus Biotechnology @nautilus.bio · 04/09/2026

This paper shows that single-molecule proteomic analysis reveals entirely new facets of biology. Specifically: 🔵 Iterative Mapping enables accessible and scalable proteoform analysis that is not possible on other platforms.

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Nautilus Biotechnology @nautilus.bio · 04/09/2026

We are incredibly proud to announce that our paper demonstrating the large-scale single-molecule analysis of tau proteoforms by Iterative Mapping has been published in Nature Methods! 📰 Press release: www.globenewswire.com/news-release... 📘 Paper: www.nature.com/articles/s41...

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Nautilus Biotechnology @nautilus.bio · 02/09/2026

🗓️ If you’d like to set up a meeting to discuss integrating the Nautilus Voyager Platform into your workflows, please fill out the form at linked here: nautilus-21430832.hs-sites-na2.com/meet-with-na... We look forward to seeing you at the conference!

nautilus-21430832.hs-sites-na2.com

Meet with Nautilus at HUPO 2026

Schedule a meeting with a Nautilus representative at HUPO 2026.

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Nautilus Biotechnology @nautilus.bio · 02/09/2026

At the event we'll also: 🔵 Invite you to be one of the first to use the platform to explore proteoforms in neurodegeneration and cancer. 🔵 Invite you to explore a model of the Nautilus Voyager Platform. 🔵 Host a panel focused on the question "Can proteoforms change our understanding of biology?"

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