iiinova — where your digital self keeps evolving

Natasha Loder @natashaloder.bsky.social · 24/08/2026

Avoid Opus 5 it is a multi-agent-spawning-token-devouring monster.

Natasha Loder @natashaloder.bsky.social · 18/08/2026

Hands up who wants a performance review for their vagina? Thanks to venture capital, the deparment of muff metrics is now issuing reports. substack.com/profile/2165...

The vaginal league table that nobody asked for

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Natasha Loder @natashaloder.bsky.social · 14/08/2026

Heathrow Runway 3: coming soon to a much-loved British landscape near you.

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Natasha Loder @natashaloder.bsky.social · 14/08/2026

Farage commenting on the democratic process as per @nyt www.nytimes.com/2026/08/14/w...

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Natasha Loder @natashaloder.bsky.social · 03/08/2026

That isn’t the sort of caption you want to see on a photo.

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Natasha Loder @natashaloder.bsky.social · 30/07/2026

I’m hoping to go to Uganda and I went to see the nurse at my GP practice just now. He recommended eight vaccines in four jabs and I said yes to every single one. 💉💉💉💉 Vaccines work and they save ✌️ ✌️✌️✌️

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Natasha Loder @natashaloder.bsky.social · 24/07/2026

I would place a small wager, that you could get the same effect with some cheap textured insoles designed for this kind of thing. Lots of people sell them--they are cheap and will work in any pair of trainers

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Natasha Loder @natashaloder.bsky.social · 23/07/2026

That was published in this chef's kiss of a medical journal: Alternative Therapies in Health and Medicine. Impact factor illustrated below (note the scale is logarithmic.)

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Natasha Loder @natashaloder.bsky.social · 28/06/2026

My grapevine laughs at your so-called heatwave.

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Natasha Loder @natashaloder.bsky.social · 11/06/2026

June 10th: open.substack.com/pub/overmatt...

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Natasha Loder @natashaloder.bsky.social · 06/06/2026

Independent trials using synthetic patient cases to stress-test chatbot responses, ongoing monitoring for model drift. The case foronly stronger than when I wrote this. overmatter.substack.com/p/we-need-to-know-more-about-how-llms

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Natasha Loder @natashaloder.bsky.social · 06/06/2026

Seven months ago I was so worried about the risks of LLMs to those with mental health crises I wrote that we urgently need independent trials of how LLMs were handling these overmatter.substack.com/p/we-need-to-know-more-about-how-llms

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Natasha Loder @natashaloder.bsky.social · 23/05/2026

Bryan Johnson earlier in the stadium that is to host the Enhanced Games tomorrow.

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Natasha Loder @natashaloder.bsky.social · 14/05/2026

I fear this thread, which started as a joke, may turn into a full time job.

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Natasha Loder @natashaloder.bsky.social · 08/05/2026

Could someone tell me what I am looking at here? 👽

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Natasha Loder @natashaloder.bsky.social · 24/04/2026

Not sure who in PR needs to hear this right now.

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Natasha Loder @natashaloder.bsky.social · 21/04/2026

Would it be unfair of me to mention that Joe Rogan was not wearing a suit to the Oval office? And dressed rather like Zelenskyy!

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Natasha Loder @natashaloder.bsky.social · 19/04/2026

American drinking is finally falling. But is it a turning point or a statistical illusion? Two very different generations have been hiding inside one trend line. A slightly data nerdy post by me on Overmatter, my Substack. open.substack.com/pub/overmatt...

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Natasha Loder @natashaloder.bsky.social · 07/04/2026

It is camellia season at home. Enjoy!!!!

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Natasha Loder @natashaloder.bsky.social · 02/04/2026

Biology beats chemistry. 🧬🤜⚗️ Small molecule drugs are yesterday's technology according to new @citeline which shows that biotech drugs now 50.1% of the pipeline after three-decade march.

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Natasha Loder @natashaloder.bsky.social · 31/03/2026

Private school pupil killed himself after ChatGPT told him how - The Telegraph. Another shocking tragedy. Unforgivable.

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Natasha Loder @natashaloder.bsky.social · 29/03/2026

Yeah, so we are definitely not landing on the Moon next month

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Natasha Loder @natashaloder.bsky.social · 28/03/2026

What I love about this paper on chatbot sycophancy is how they did their experiment, by comparing chatbot responses and human responses to Am I The Asshole threads on Reddit. www.science.org/doi/10.1126/...

chart showing how scientists tested chatbot sycophancy

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Natasha Loder @natashaloder.bsky.social · 24/03/2026

America plans to allow the sale of around 14 peptide drugs, which are untested, unregulated but which pose safety risks according to the FDA. What could possibly go wrong? Read on to find out more. 💉https://open.substack.com/pub/overmatter/p/biohack-inject-repeat-the-age-of

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Natasha Loder @natashaloder.bsky.social · 24/03/2026

The sound of happy bees. Welcome to Spring. Enjoy with sound up.

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Natasha Loder @natashaloder.bsky.social · 08/03/2026

I loved writing this story about "peak booze" and what it might mean. Read about it here, and find out about the forthcoming NPR show on this story. 🥂🍷🍺 open.substack.com/pub/overmatt...

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Natasha Loder @natashaloder.bsky.social · 26/02/2026

Decades of social media harms on kids and this token move by social media firms ONLY when governments start legislating. This 👉 PR-driven stunt has done more than anything to convince me of the need government action now. They could have done this years ago but chose not to bother.

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Natasha Loder @natashaloder.bsky.social · 02/02/2026

Greetings from Abu Dhabi and the Enhanced Games Training camp.

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Natasha Loder @natashaloder.bsky.social · 22/01/2026

Last week I was furious about a BMJ study that guessed that GLP-1 weight loss would fully rebound in 1.7 years, the lack of real world data, and the negative commentary about people who take these meds. Guess what? Real world data from firm nference shows most patients don't regain the weight.

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Natasha Loder @natashaloder.bsky.social · 22/01/2026

The American right is hallucinating over ibogaine. A wave of conservative evangelism is colliding with one of the riskiest psychedelics in the medicine cabinet. A new post with Anne Phillipi, of The New Health Club Podcast. Read, share, and let me know what you think.

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Natasha Loder @natashaloder.bsky.social · 28/11/2025

Look what just arrived. A new book by Deb Cohen out January. Has the internet hijacked your health? Read her book.

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Natasha Loder @natashaloder.bsky.social · 19/09/2025

The big picture on UK pharma exits from Citeline

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Natasha Loder @natashaloder.bsky.social · 18/08/2025

Scientists say this picture could be lungfish taking their first steps on the ground as they evolved from teh water. I think they had pogo sticks. www.science.org/content/arti...

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Natasha Loder @natashaloder.bsky.social · 27/06/2025

My tour of alcohol free functional drinks continues with this nicely hoppy beer with some really interesting light botanical flavours and a bitter finish. Surprisingly nice.

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Natasha Loder @natashaloder.bsky.social · 18/06/2025

At the launch of an exciting new book by my dear and clever friend Aisha Hassan @orionbooks

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Natasha Loder @natashaloder.bsky.social · 13/06/2025

This poppy has made the local bees very happy (if buzzing is anything to go by)

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Natasha Loder @natashaloder.bsky.social · 13/06/2025

I love succulents. They sit there for years doing not much at all, then they pull stunts like this.

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