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Narcoplexic @narcoplexic.bsky.social · 05/08/2026

www.fda.gov/news-events/... Go Takeda! orzeyful.com Is going to be an interesting few years to decade as this 'gold rush' in sleep medicine, plays out. The title use of 'full range' is a stretch, for some sure but it's already pretty clear, not for everyone. Though likely the best option yet.

fda.gov

FDA Approves First Drug to Treat the Full Range of Narcolepsy Type 1 Symptoms

The FDA approved Orzeyful (oveporexton) tablets for the treatment of narcolepsy type 1 in adults.

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Narcoplexic @narcoplexic.bsky.social · 29/11/2025

"Leo's Daily Normal" - a graphic novel series illustrating the reality of life with different sleep disorders. Edition #1 is available now. Edition #2 is in production. Support independent advocacy. patreon.com/Narcoplexic #Narcolepsy #SleepApnea #DSPD #PatientAdvocacy #GraphicNovel #SleepHealth

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Narcoplexic @narcoplexic.bsky.social · 05/11/2025

Will be on the podcast: 'Sleep Is My Waking Passion' Fri - Nov. 21st 2025 www.askthesleepmd.com I'll be speaking on living with Type 1 #narcolepsy, severe-complete #cataplexy, evolving the terminology as well as my efforts toward bridging the gap between the clinical science & the human experience.

askthesleepmd.com

Ask The Sleep MD

Unlock better sleep with AskTheSleepMD.com. Led by certified sleep specialist Alison S. Kole, MD, MPH, FACCP, we provide evidence-based advice, tips, and product reviews to optimize your sleep. From s...

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Narcoplexic @narcoplexic.bsky.social · 08/10/2025

Reach out to Dr. Anne Marie Morse (DAMMgoodsleep). She is at the top of the field and she is genuine, caring while very knowledge-able.

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Narcoplexic @narcoplexic.bsky.social · 08/10/2025

My life was dramatically altered at the age of 20 from severe complete Cataplexy on a regular frequent basis, I'll never be able to live how I could before. I'm 45 now and still impacted by those effects. So many trade-offs in this life, things most can't fathom not being part of their normal...

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Narcoplexic @narcoplexic.bsky.social · 08/10/2025

Which makes it extremely hard for people to not just get off them, but be able to return to their baseline in any reasonable amount of time, if at all. Most diseases have a drug or two that work, with N there is a commonality that it takes different combinations over time, changing regularly too.

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Narcoplexic @narcoplexic.bsky.social · 08/10/2025

There are people like myself, who have never tolerated nor benefited from any of the stims, antidepressants, or any of it. Hoping the Orexin Agonists will be tolerable and beneficial but time will tell. As for the older stimulants, they have an EDS compounding effect when withdrawing from them.

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Narcoplexic @narcoplexic.bsky.social · 08/10/2025

As for the schizophrenia, I heard Dr. Ortiz say that around or less than 1% of PWN have or receive a dx of such. But the misdiagnosis is not uncommon - because of how misunderstood, little is understood, by the common doctors out there, when it comes to N.

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Narcoplexic @narcoplexic.bsky.social · 08/10/2025

Narcolepsy is brutal, and so barely begun to be understood, far less recognized, comprehended and furthest of all acknowledged for what it is and can be -> neurologic system dysfunction + many comorbidities, sensitivities, etc. The meds can work for some, not all, and most have to juggle over time.

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Narcoplexic @narcoplexic.bsky.social · 09/09/2025

This American Goldfinch looks more like Cotton Candy! #birds

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Narcoplexic @narcoplexic.bsky.social · 27/06/2025

Good to see some studying/focus into the Orexin A.

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Narcoplexic @narcoplexic.bsky.social · 13/06/2025

Big stuff: "Locus coeruleus neurons facilitate muscle tone, thus their loss is responsible for cataplexy. These noradrenergic neurons also have ascending axons and their loss decreases altertness ( doi.org/10.1101/2025... )" teams.semel.ucla.edu/sleep-research #narcolepsy #cataplexy #sleeppeeps

teams.semel.ucla.edu

Sleep Research | Semel Institute for Neuroscience and Human Behavior

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Narcoplexic @narcoplexic.bsky.social · 03/06/2025

Criminals who belong behind bars.

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Narcoplexic @narcoplexic.bsky.social · 29/05/2025

Cataplexy is a brutal symptom/condition that is part of having Type 1 Narcolepsy; few people understand or can begin to fathom it, for what it is to live with. The claim is completely respectable.

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Narcoplexic @narcoplexic.bsky.social · 24/05/2025

That was to hit on the current, Orexin B formula in trials. They don't seem to be improving the disrupted nighttime sleep. Perhaps, an alternate Orexin B formula will work for improving nighttime sleep? Likely daytime Agonist, with the Oxybate's or other nighttime med/s, will be necessary for some.

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Narcoplexic @narcoplexic.bsky.social · 24/05/2025

The upcoming, currently in trials, Orexin B Agonist seems to help with wakefullness. Whether that means a plethora of other things like vigilance, emotional processing, alertness, energy levels, appetite/metabolism, etc (& so much more); is to be determined. Improved sleep, does not seem to be part.

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Narcoplexic @narcoplexic.bsky.social · 22/05/2025

Please figure out how to help with the disrupted fragmented nighttime sleep side of Narcolepsy, not just the excessive daytime sleepiness side.

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Narcoplexic @narcoplexic.bsky.social · 19/05/2025

Hopefully they'll also figure out how to improve the disrupted nighttime sleep part of Narcolepsy, as that is still a huge element, one that few actually realize or recognize as a part of it. The human experience has not been focused in on, enough, when it comes to living with Narcolepsy.

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Narcoplexic @narcoplexic.bsky.social · 03/05/2025

Could be Cataplexy which is a symptom of Narcolepsy involving the 'muscle atonia' seen during REM sleep = muscular interference/s to full paralysis triggered by stimulation of emotion. The question is: whether or not she during 'remained fully conscious, or was blacking out.' Her friend seems aware.

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Narcoplexic @narcoplexic.bsky.social · 01/05/2025

narcoplexic.com/beyond-weakn... Beyond Weakness: Muscle Interference and the Fight for Cataplexy Awareness #narcolepsy #cataplexy #awareness #advocacy #sleeppeeps #chronicillness #invisibleillness

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Narcoplexic @narcoplexic.bsky.social · 17/04/2025

AS @xantar.bsky.social mentions, that is a part of the roller coaster that living with Narcolepsy involves, both frequent dreaming while awake and being awake while dreaming.

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Narcoplexic @narcoplexic.bsky.social · 16/04/2025

It be nice if disease weren't just a money profit hole. If there was focus onto the lived human experience rather than this obsession with well, blockbu$ter drugs. I'd like to see an expansion in perception, focus, care, opposed to the endless pursuit, looping circularly, towards meds, meds, meds...

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Narcoplexic @narcoplexic.bsky.social · 16/04/2025

Type 1 Narcolepsy is connected to the lack or total loss of Orexin. The disease occurs due to an autoimmune attack origin, deep in the Hypothalamus, it is so much more than a Sleep Disorder. There's likely more going on in the disease. Could ME/CFS actually be much more in line or even a part of N.

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Narcoplexic @narcoplexic.bsky.social · 11/04/2025

Trying to figure out how to do photography and art on my own, hasn't quite worked out, yet.

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Narcoplexic @narcoplexic.bsky.social · 11/04/2025

Regardless, it's still shitty to use in a joking context. You obviously could care less so whatever, go be a jock.

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