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Meaghan Perdue

@mvperduephd.bsky.social

241 followers 490 following 9 posts

Postdoc @UMassChan Shriver Center Child and Adolescent NeuroDevelopmental Initiative studying brain and cognitive development in kids 🧠📚, former postdoc @UCalgary

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Meaghan Perdue @mvperduephd.bsky.social · 27/02/2025

Post-hoc analysis showed marginal effects of microstructural lateralization, with better decoders showing leftward lateralization from early in development

Interaction plot showing association between age (x-axis) and arcuate fasciculus microstructural asymmetry (y-axis) moderated by decoding ability(color scale: lighter colors=better decoding scores). Fit lines show age-asymmetry association for poorer readers (purple long-dash), sample mean (solid magenta line) and better decoders (pink short-dash)

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Meaghan Perdue @mvperduephd.bsky.social · 21/11/2024

Total choline in the anterior cingulate cortex (ACC) was associated with overall executive functioning in children with an without alcohol exposure, while glutamate+glutamine in the ACC was uniquely associated with inhibitory control in the alcohol-exposed group

scatter plots showing (A) the association between glutamate+glutamine (Glx) and inhibitory control indexed by the NEPSY-II Statue Total Scaled score: interaction effect shows a relation between higher Glx and poorer Statue scores in children with Prenatal Alcohol Exposure (shown in orange), but not unexposed children (shown in purple); and (B) the association between total choline (tCho) and overall executive functioning indexed by the BRIEF GEC T-score (higher T-scores indicate more difficulties with global executive functioning), children with prenatal alcohol exposure had higher BRIEF GEC T-scores than unexposed children, and higher tCho levels were associated with lower BRIEF GEC T-scores within both groups

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Meaghan Perdue @mvperduephd.bsky.social · 09/05/2024

🚨New Preprint!🚨 doi.org/10.1101/2024... We found elevated choline and glutamate/glutamine in young children exposed to alcohol in utero vs unexposed children, and metabolite levels were associated with executive functioning indexed by parent report and a motor inhibitory control task

Scatter plots showing the association between metabolites (X-axes, left=Glx, right=tCho) and executive functioning (Y-axes, left=NEPSY-II Statue Total Scaled Score, right=BRIEF Global Executive Composite T-score). Panel A shows interaction by Alcohol Exposure group with negative effect in children with alcohol exposure. Panel B shows Main effects of higher BRIEF GEC T-scores (more difficulties with exeutive function) in the alcohol exposed group, and higher tCho is associated with better executive function in both groups

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