Thrilled to announce our group's latest paper in JACS by co-1st Authors Tianze Zhang (now at Crick) & Luis Guerra; great collaboration with Yana Berlina, Beat Fierz (EPFL) and Jon Wilson (Crick): doi.org/10.1021/jacs...
doi.org
Semisynthesis of Isomerized Histone H4 Reveals Robustness and Vulnerability of Chromatin toward Molecular Aging
Proteins are subject to aging in the form of spontaneous, nonenzymatic post-translational modifications (PTMs). One such PTM is the formation of the β-linked isomer l-isoaspartic acid (isoAsp) from as...