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Mora Ogando

@moraogando.bsky.social

132 followers 212 following 17 posts

Postdoctoral researcher at Hillel Adesnik's lab in UC Berkeley. Interested in causally understanding learning and memory

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Mora Ogando @moraogando.bsky.social · 05/08/2025

Huge thanks to all the authors!!, especially @lamiaeadm.bsky.social who designed and built this powerful all-optical system, and to the great Adesnik Team!!

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Mora Ogando @moraogando.bsky.social · 05/08/2025

So WHY is the brain wired with a like-to-like inhibitory loop? Stimulating co-tuned SSTs while showing their preferred visual input: -Reduces evidence for flanking orientations (consistent with explaining away) -Preserves evidence for correct orientation -Boosts discriminability

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Mora Ogando @moraogando.bsky.social · 05/08/2025

In fact, directly activating co-tuned SST ensembles alone is sufficient to remove input-matching representations in the absence of visual input.

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Mora Ogando @moraogando.bsky.social · 05/08/2025

Feature completion can be explained by the well-known like-to-like PC-PC connectivity in V1, but where does the feature-specific suppression come from? -PCs recruit co-tuned SSTs (not PVs) -SSTs, in turn, suppress co-tuned PCs → a “like-to-like-to-like” inhibitory loop

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Mora Ogando @moraogando.bsky.social · 05/08/2025

Using all-optical physiology in awake mice we photostimulated orientation-tuned PC ensembles in V1 in the absence of visual input, and we found: Small PC ensembles → dominant feature suppression Large PC ensembles → dominant feature completion

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