iiinova — where your digital self keeps evolving

🧬Jason V. Freddybaum, MD🧬 (he/him) @mopathguy.bsky.social · 08/09/2026

There are all kinds of career paths available to a pathologist…

Image of a G.I. JOE action figure of “COBRA industries CEO” featuring a man with white hair and a blue hazmat suit

Action figure card back with “laboratory director” highlighted

COBRA INDUSTRIES C.E.O.
Code Name: CESSPOOL™
COBRA
File name: D'Alleva, Vincent A.
Primary Military Specialty: Chief Executive Officer
Secondary Military Specialty: Laboratory Director
Birthplace: Newton, Massachusetts
CESSPOOL was the Chief Executive Officer of a huge multi-national corporation with vast holdings in oil refineries, chemical plants, and mills. In an effort to placate environmental groups, he took them on a tour through one of his chemical plants, where an accidental exposure to the toxic waste left him horribly disfigured. For reparations, he took his knowledge of high-level dirty dealings and corporate subterfuge straight to the COBRA organization. He soon created a weapons grade Plasma-Tox and portable dispersal system.
However, he found that long-term exposure turned some of his men into uncontrollable creatures. He was eventually caught by the G.I. JOE team and incarcerated for many years.
CESSPOOL secretly plotted to find ways to get back at society, and discover an additive that would let him control exposed personnel. Upon his release, he went directly back to where his experiments left off. He now oversees all chemical engineering and custom synthesis of Compound Z at COBRA laboratories. Anyone exposed to this chemical becomes a zombie like drone. He plans to create an army of ZOMBIE-VIPERS and exact his revenge on the world.
"I will make the world as ugly and nasty as I am!"
Characters and events referenced herein are fictional and are not intended to depict actual persons and events.

🧬Jason V. Freddybaum, MD🧬 (he/him) @mopathguy.bsky.social · 05/06/2026

Went whale-watching today in Vancouver. Had low expectations based on only prior trip during which we saw no whales. Today, saw orcas breaching, humpbacks breaching, humpbacks lunge feeding. Plurals all appropriate. Took some video, but didn’t react quick enough for the best stuff.

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🧬Jason V. Freddybaum, MD🧬 (he/him) @mopathguy.bsky.social · 12/01/2026

Have to applaud the commitment to the dad joke in naming this “milkshake bar” in Berkeley, CA. Also applaud the milkshakes.

Picture of a sign above the door of a restaurant saying “The Yard Milkshake Bar”

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🧬Jason V. Freddybaum, MD🧬 (he/him) @mopathguy.bsky.social · 02/01/2026

Publicly boasting about the results of your cognitive exam should result in automatic failure of your cognitive exam.

Post from Donald J. Trump • ©
@realDonaldTrump

The White House Doctors have just reported that I am in
"PERFECT HEALTH," and that I "ACED" (Meaning, was correct on 100% of the questions asked!), for the third straight time, my Cognitive Examination, something which no other President, or previous Vice President, was willing to take. P.S., I strongly believe that anyone running for President, or Vice President, should be mandatorily forced to take a strong, meaningful, and proven Cognitive Examination. Our great Country cannot be run by "STUPID" or INCOMPETENT PEOPLE! President DJT
2.27k ReTruths 8.86k Likes
Jan 02, 2026, 6:56 AM

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🧬Jason V. Freddybaum, MD🧬 (he/him) @mopathguy.bsky.social · 29/07/2025

At the USS Midway decommissioned aircraft carrier and museum in San Diego:

In front of the USS Midway site a wooden crate marked with military style black paint that says: DO NOT DESTROY - RETURN TO DIPPIN DOTS

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🧬Jason V. Freddybaum, MD🧬 (he/him) @mopathguy.bsky.social · 11/07/2025

Circling back to the original question, confirming one lab test with another is sometimes necessary. Your positive test was probably a screen, and confirming that result with a diagnostic is 100% appropriate. To sum up: screens and diagnostics are “Two Great Tests That Test Great Together”

A Reese's Peanut Butter Cup with a large bite taken from it.

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🧬Jason V. Freddybaum, MD🧬 (he/him) @mopathguy.bsky.social · 11/07/2025

So, if we start with the strainer, we will catch all the coins and a few of the larger snails. If we then use our highly specific eyes to examine what we strained, we can exclude the snails. We end up with the best result – we bring home all the coins and no snails! 5/n

A cartoon of a beach. A sifter is suspended over the beach, which contains 6 coins. Disembodied eyes appear to be looking at the sifter, and underneath the eyes are 3 large snails which appear to have been discarded. On the beach are 7 small snails, two of which are partially buried.

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🧬Jason V. Freddybaum, MD🧬 (he/him) @mopathguy.bsky.social · 11/07/2025

We could use our eyes to easily find visible coins - we’ll miss buried coins but won’t accidentally grab many snails. Or we could use a strainer which will catch nearly all the coins but also some snails. 3/n

A cartoon of a beach with disembodied eyes looking at a disembodied hand holding three coins. On the beach are 3 coins partially buried in the sand, and 11 snails, 2 of which are partially buried in the sand.

A cartoon of a beach. A sifter is suspended over the beach, which contains 6 coins and 3 large snails. Remaining on the beach are 7 small snails, two of which are partially buried.

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🧬Jason V. Freddybaum, MD🧬 (he/him) @mopathguy.bsky.social · 11/07/2025

The answer without math: imagine a sandy beach with coins and snails. Ideally, we want to take home all the coins, leaving all the snails at the beach. 2/n

A cartoon of a beach with 6 coins, 3 partially buried in the sand. There are also 3 large snails, 1 partially buried, and 8 small snails, 1 partially buried.

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🧬Jason V. Freddybaum, MD🧬 (he/him) @mopathguy.bsky.social · 15/04/2025

1995: I drove my car into a tree on spring break. 2025:

A photo of a minivan being driven through a live sequoia tree.

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🧬Jason V. Freddybaum, MD🧬 (he/him) @mopathguy.bsky.social · 07/04/2025

Is there a better image for an economy in arrest?

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🧬Jason V. Freddybaum, MD🧬 (he/him) @mopathguy.bsky.social · 24/03/2025

@ampath.bsky.social gave me my own personalized social media promo! It’s me from ten years ago! Next to GIANT DNA!!!

AMP Live Virtual Review Course
Molecular Genetic Pathology
May 12-16
Faculty
Jason N. Rosenbaum, M.D.
Kaiser Permanente, Northern California

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🧬Jason V. Freddybaum, MD🧬 (he/him) @mopathguy.bsky.social · 11/03/2025

Handmade robots sort of miss the point, don’t they?

A photo of a fuzzy bunny on a living room floor, with the headline “The Handmade Most Realistic Bunny Robot Toys of 2025”

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🧬Jason V. Freddybaum, MD🧬 (he/him) @mopathguy.bsky.social · 28/02/2025

I’d like to report discrimination against the self-aware

Image from a Department of Education submission form: “Schools should be focused on learning.
The U.S. Department of Education is committed to ensuring all students have access to meaningful learning free of divisive ideologies and indoctrination. This submission form is an outlet for students, parents, teachers, and the broader community to report illegal discriminatory practices at institutions of learning.
The Department of Education will utilize community submissions to identify potential areas for investigation.”

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🧬Jason V. Freddybaum, MD🧬 (he/him) @mopathguy.bsky.social · 12/12/2024

The AP comes in hot with a photo for its readers who don’t know what a head is.

Photo of a Bluesky post from AP. Headline:
Brazil's Lula undergoes a second procedure to address bleeding inside his head.
Photo: The back of a bald white guy’s head.

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🧬Jason V. Freddybaum, MD🧬 (he/him) @mopathguy.bsky.social · 22/11/2024

“There’s will be a medical specialty called ‘molecular pathology’” “What’s ‘molecular?’” “Everything” “What’s pathology?” “Nobody knows.” #Pathsky #mopath #medsky

Image of a sketch from Saturday Night Live featuring Nate Bargatze as George Washington speaking to three revolutionary soldiers.

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🧬Jason V. Freddybaum, MD🧬 (he/him) @mopathguy.bsky.social · 22/11/2024

This early morning Wicked screening is not what I expected #AMP2024

Dr. Rebecca Ramesh presenting a slides comparing two NGS bam pileups to confirm a mutation in extramedullary AML.

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🧬Jason V. Freddybaum, MD🧬 (he/him) @mopathguy.bsky.social · 20/11/2024

#AMP2024 you can’t build a giant killer whale out of legos… orca-n you?

Orca statue at the Vancouver convention center, which appears to be built from plastic bricks

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🧬Jason V. Freddybaum, MD🧬 (he/him) @mopathguy.bsky.social · 10/11/2024

Spouse: Why is all this in a food container? Me: It’s locks

Photo of an airtight plastic food container containing locks

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🧬Jason V. Freddybaum, MD🧬 (he/him) @mopathguy.bsky.social · 08/11/2024

TLDR: Tumor mutational burden (#TMB), like polling, suffers from sampling and methodological bias. This contributes to its unreliability as a biomarker, and makes it difficult to harmonize between assays. 20/20

Count Von Count, the vampire muppet with an obsessive fixation on counting, and famous resident of Sesame Street.

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🧬Jason V. Freddybaum, MD🧬 (he/him) @mopathguy.bsky.social · 08/11/2024

#TMB is only a proxy because the immune system mostly recognizes proteins, not the genes which encode them. If a mutated gene is never expressed as a protein, it shouldn't "count." However, it is much easier to sequence DNA than to globally assess proteins. 3/20

The central dogma of molecular biology: DNA self-replicates by DNA polymerase, and is transcribed to RNA by RNA polymerase. RNA is translated to protein by ribosomes. From wikipedia: https://en.wikipedia.org/wiki/Central_dogma_of_molecular_biology

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🧬Jason V. Freddybaum, MD🧬 (he/him) @mopathguy.bsky.social · 02/04/2024

Today was the official ribbon-cutting for the Kaiser Permanente Northern California Regional Genomics Laboratory. Excited to bring state of the art genomics testing to KPNC members!

KPNC Regional Genomics Lab staff at the ribbon cutting on 4/1/24

Custom cookies for the Regional Genomics Lab

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🧬Jason V. Freddybaum, MD🧬 (he/him) @mopathguy.bsky.social · 11/12/2023

You guuuuuys… med school is sooooo haaaaard!!!!

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