iiinova — where your digital self keeps evolving

Erik Poppleton @poppleton.phd · 23/06/2025

Reposted by Molpigs

Molecular Programmers🧬: @programmablematter.bsky.social summons us to organize a “Flightplan”, a 10-year strategic initiative for the field. The meeting will be July 21-23rd in Seattle and will be moderated by NSF program officers. Travel funding is available! Apply here: mpflightplan.com/apply-now

mpflightplan.com

Apply now! — MP Decadal Flightplan

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Molpigs @molpigs.bsky.social · 02/05/2025

Follow WONDER for networking opportunities and upcoming mentorship events aimed at increasing female representation and retention in the Molecular Programming field 🧬

Molpigs @molpigs.bsky.social · 29/04/2025

Thank you to everybody who came to our 🧬DNA origami🧬 reading group over the last 7 weeks! We all learned a ton from the discussions and revisiting these classic papers. What should our next topic be?? Leave us a comment to help us decide.

Molpigs @molpigs.bsky.social · 19/04/2025

It's time for the finale of the 🧬DNA origami🧬 reading group! This week we're thinking about how to make origami biiiiiig. When previous papers assembled multiple origami, the yield started to crash. This week's paper is an attempt to get around that problem. www.nature.com/articles/s41...

Multi-micron crisscross structures grown from DNA-origami slats - Nature Nanotechnology

Addressable DNA structures with lateral dimensions of ~2 µm can be self-assembled starting from over 1,000 distinct DNA-origami monomers via joint capture of the non-nearest neighbours.

Molpigs @molpigs.bsky.social · 13/04/2025

This week in the Molpigs 🧬DNA Origami🧬 Reading Group there are two cool concepts we're exploring: dynamic structures, and using blunt-end stacking as a structural tool instead of treating it as The Enemy. Info on how to join the discussion in the quoted thread! www.science.org/doi/full/10....

science.org

Molpigs @molpigs.bsky.social · 06/04/2025

This week in the Molpigs 🧬DNA Origami🧬 Reading Group, we're exploring how DNA origami went from tightly packed sheets/blocks, to open wireframes with complex and beautiful geometries. This paper required designing intricate strand routing, let's follow the path! www.nature.com/articles/nna...

Complex wireframe DNA origami nanostructures with multi-arm junction vertices - Nature Nanotechnology

A design approach for engineering wireframe DNA nanostructures, in which each vertex and line segment can be individually controlled, can be used to fabricate complex structures including quasicrystal...

Molpigs @molpigs.bsky.social · 30/03/2025

Welcome to the halfway point in the 🧬DNA origami🧬 reading group! This week we're reading "Folding DNA into Twisted and Curved Nanoscale Shapes", the second 2009 paper from the Shih lab demonstrating the programmability of DNA origami. www.science.org/doi/full/10....

science.org

Molpigs @molpigs.bsky.social · 23/03/2025

For week three of our 🧬DNA origami🧬 reading group we're reading the first of two 2009 papers from the Shih lab which demonstrated that you really could fold DNA into any 3D shape! This paper also demonstrated Cadnano, which remains the most used design software today. www.nature.com/articles/nat...

Self-assembly of DNA into nanoscale three-dimensional shapes - Nature

DNA has proved to be a versatile building block in the creation of complex structures through self-assembly, exploiting the intermolecular forces between the components. Here, the arrangement of DNA h...

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Molpigs @molpigs.bsky.social · 20/03/2025

The second meeting of the Origami Reading Group is tonight at 18:00 EST! Come discuss the original DNA Origami with us (spoiler, it’s shockingly sassy). 🧬

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Molpigs @molpigs.bsky.social · 15/03/2025

It's time to put the origami in our DNA Origami Reading Group! This week we're reading Rothemund's "Folding DNA to create nanoscale shapes and patterns" to understand this seminal paper in context! What did Rothemund know, and what did he intuit? Join us to discuss!🧬 www.nature.com/articles/nat...

Folding DNA to create nanoscale shapes and patterns - Nature

A robust, versatile, one-pot bottom-up nanotechnology fabrication method uses a few-hundred short DNA strands to 'staple' a very long strand into two-dimensional structures of 100 nm in diameter and r...

Molpigs @molpigs.bsky.social · 11/03/2025

First 🧬DNA Origami reading group🧬 meets today! Our first paper is a precursor to origami, where Yan and colleagues showed that you could build larger structures via scaffolded tile assembly! www.pnas.org/doi/10.1073/...

pnas.org

Directed nucleation assembly of DNA tile complexes for barcode-patterned lattices | PNAS

The programmed self-assembly of patterned aperiodic molecular structures is a major challenge in nanotechnology and has numerous potential applica...

Molpigs @molpigs.bsky.social · 08/03/2025

Excited to start our 🧬DNA origami🧬 reading group next week! We’ll be hosting two weekly sessions: Tuesday @ 20:15 CET Thursday @ 18 EST You can still sign up by joining the reading-group channel on Slack or filling the form for email updates! Timezone converter: molpi.gs/timezones#tz...

molpi.gs

Molecular Programming Interest GroupMolecular Programming Interest Group

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Molpigs @molpigs.bsky.social · 02/03/2025

It's time for another Molpigs reading group! This time we'll be routing our brains through the history of DNA origami. We will be starting the week of March 10th and reading 1 paper/week for 7 weeks. Please fill out either the form linked in the next post or join the Molpigs Slack for updates. 🧬🧬🧬

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Molpigs @molpigs.bsky.social · 25/11/2024

In this series on the origins of DNA nanotechnology, we've so far seen a lot of DNA, not a lot of nanostructure and not a lot of technology. Today's paper introduces structure, we're looking at the first well-defined object built out of DNA, the humble cube! 🧬 1/8 www.nature.com/articles/350...

Synthesis from DNA of a molecule with the connectivity of a cube - Nature

Nature - Synthesis from DNA of a molecule with the connectivity of a cube

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Molpigs @molpigs.bsky.social · 21/11/2024

DNA nanotechnology works because of the specificity of A-T and G-C base-pairs. But isolated pairs aren't stable! Only when you have longer stretches will DNA form a helix. Before finally building the first structure, let's discuss Ned's sequence design tool. 1/6 www.tandfonline.com/doi/pdf/10.1...

tandfonline.com

De Novo Design of Sequences for Nucleic Acid Structural Engineering: Journal of Biomolecular Structure and Dynamics: Vol 8 , No 3 - Get Access

We’re here to help

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Molpigs @molpigs.bsky.social · 14/11/2024

Paper #3 in our series: the time Ned and co read too much science fiction. That's right, it's Robinson & Seeman's "The design of a biochip: a self-assembling molecular-scale memory device" published in Protein Engineering in 1987. 🧬 1/7 academic.oup.com/peds/article...

academic.oup.com

The design of a biochip: a self-assembling molecular-scale memory device

Abstract. A design for a biochip memory device based on known materials and existing principles is presented. The fabrication of this memory system relies

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Molpigs @molpigs.bsky.social · 13/11/2024

Wake up and smell the acrylamide! Today we're talking about the second paper in our retrospective on Ned Seeman's work, "An immobile nucleic acid junction constructed from oligonucleotides", Nature 1983. 🧬 1/5 www.nature.com/articles/305...